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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : CTD - acetylleucyl-leucyl-norleucinal

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Collection	D4 : CTD
Chemical Name	acetylleucyl-leucyl-norleucinal ( From PubChem : CALPAIN INHIBITOR I )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 383.525 g/mol 3 7 3.1147 True
Structure
InChI	InChI=1S/C20H37N3O4/c1-7-8-9-16(12-24)22-19(26)18(11-14(4)5)23-20(27)17(10-13(2)3)21-15(6)25/h12-14,16-18H,7-11H2,1-6H3,(H,21,25)(H,22,26)(H,23,27)
InChIKey	FMYKJLXRRQTBOR-UHFFFAOYSA-N
Links
Gene (17 / 52) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD decreases(reaction) APOB C063261 CTD decreases(secretion) APOB C063261 CTD decreases(expression) APOB C063261 CTD decreases(reaction) APOB C063261 CTD decreases(secretion) APOB C063261 CTD increases(expression) APOB C063261 CTD increases(secretion) APOB C063261 CTD decreases(reaction) CCNB1 C063261 CTD increases(degradation) CCNB1 C063261 CTD decreases(reaction) CCND1 C063261 CTD increases(degradation) CCND1 C063261 CTD decreases(expression) CCND1 C063261 CTD decreases(reaction) CCND1 C063261 CTD increases(degradation) CCND1 C063261 CTD decreases(expression) CCND3 C063261 CTD decreases(reaction) CCND3 C063261 CTD increases(degradation) CCND3 C063261 CTD decreases(reaction) CDC20 C063261 CTD increases(degradation) CDC20 C063261 CTD increases(reaction) CDC20 C063261 CTD increases(ubiquitination) CDC20 C063261 CTD decreases(reaction) CXCL8 C063261 CTD increases(expression) CXCL8 C063261 CTD decreases(expression) EIF4E C063261 CTD decreases(reaction) EIF4E C063261 CTD decreases(expression) GJA1 C063261 CTD decreases(reaction) GJA1 C063261 CTD decreases(reaction) IL1B C063261 CTD increases(ubiquitination) IL1B C063261 CTD increases(expression) ITGAM C063261 CTD increases(reaction) ITGAM C063261 CTD decreases(expression) NFKBIA C063261 CTD decreases(reaction) NFKBIA C063261 CTD increases(degradation) NFKBIA C063261 CTD decreases(reaction) NFKBIA C063261 CTD increases(ubiquitination) NFKBIA C063261 CTD decreases(degradation) NFKBIA C063261 CTD decreases(reaction) RAD51 C063261 CTD increases(expression) RAD51 C063261 CTD affects(cotreatment) RAD51 C063261 CTD decreases(expression) RAD51 C063261 CTD decreases(expression) SCNN1G C063261 CTD increases(methylation) SCNN1G C063261 CTD affects(cotreatment) TYMP C063261 CTD decreases(reaction) TYMP C063261 CTD decreases(stability) TYMP C063261 CTD affects(cotreatment) TYMS C063261 CTD decreases(reaction) TYMS C063261 CTD decreases(stability) TYMS C063261 PubChem Potency uM 1.125 TDP1 - GI(Protien) : PubChem Potency uM 1.262 TDP1 - GI(Protien) : ChEMBL Activity - CFL1 - Target : CHEMBL1075129
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