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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : CTD - 2,3-dimethoxy-1,4-naphthoquinone

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Collection	D4 : CTD
Chemical Name	2,3-dimethoxy-1,4-naphthoquinone ( From PubChem : DMNQ )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 218.205 g/mol 0 4 1.57 True
Structure
InChI	InChI=1S/C12H10O4/c1-15-11-9(13)7-5-3-4-6-8(7)10(14)12(11)16-2/h3-6H,1-2H3
InChIKey	ZEGDFCCYTFPECB-UHFFFAOYSA-N
Links
Gene (157 / 174) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD decreases(expression) ACOT2 C063002 CTD decreases(expression) ACP2 C063002 CTD decreases(expression) ACSL1 C063002 CTD decreases(expression) ADH6 C063002 CTD increases(expression) ADM C063002 CTD increases(expression) AKAP12 C063002 CTD decreases(expression) AKR1B1 C063002 CTD increases(expression) AKR1C1 C063002 CTD decreases(expression) ALDH6A1 C063002 CTD increases(expression) ANXA2 C063002 CTD decreases(expression) ARSE C063002 CTD decreases(expression) ASNS C063002 CTD increases(expression) ATF4 C063002 CTD decreases(expression) ATP2B1 C063002 CTD increases(expression) AURKA C063002 CTD decreases(expression) AZGP1 C063002 CTD decreases(expression) BCAT1 C063002 CTD increases(expression) BHLHE40 C063002 CTD increases(expression) BIRC5 C063002 CTD increases(expression) BUB1B C063002 CTD decreases(expression) C6ORF48 C063002 CTD decreases(expression) CALR C063002 CTD increases(expression) CCNA2 C063002 CTD increases(expression) CCNB2 C063002 CTD increases(expression) CDC20 C063002 CTD increases(expression) CDC25B C063002 CTD decreases(expression) CDH2 C063002 CTD increases(expression) CDKN3 C063002 CTD decreases(expression) CETN2 C063002 CTD decreases(expression) CFB C063002 CTD decreases(expression) CHPT1 C063002 CTD decreases(expression) CIDEB C063002 CTD increases(expression) CKS2 C063002 CTD decreases(expression) CLGN C063002 CTD decreases(expression) CLPTM1 C063002 CTD decreases(expression) CLU C063002 CTD decreases(expression) CRYAA C063002 CTD decreases(expression) CX3CL1 C063002 CTD increases(expression) CYP1A1 C063002 CTD increases(expression) DDIT3 C063002 CTD increases(expression) DKK1 C063002 CTD increases(expression) DUSP13 C063002 CTD increases(phosphorylation) EIF2AK3 C063002 CTD increases(phosphorylation) EIF2S1 C063002 CTD decreases(expression) EPHX1 C063002 CTD decreases(expression) F10 C063002 CTD decreases(expression) F5 C063002 CTD increases(expression) FOSL1 C063002 CTD decreases(expression) FURIN C063002 CTD decreases(expression) GGCX C063002 CTD decreases(expression) GHITM C063002 CTD increases(expression) GLA C063002 CTD decreases(expression) GPER1 C063002 CTD increases(expression) GRB10 C063002 CTD decreases(expression) GSN C063002 CTD increases(expression) GTPBP6 C063002 CTD increases(expression) H2AFX C063002 CTD increases(expression) HIST1H4C C063002 CTD increases(expression) HMGA1 C063002 CTD increases(expression) HMGN2 C063002 CTD increases(expression) HMOX1 C063002 CTD increases(expression) IER2 C063002 CTD decreases(expression) IFRD1 C063002 CTD decreases(expression) IGSF1 C063002 CTD decreases(expression) IL17RB C063002 CTD increases(expression) ITGB3BP C063002 CTD decreases(expression) ITIH3 C063002 CTD increases(expression) KIF20B C063002 CTD increases(expression) KIF22 C063002 CTD increases(expression) KIF23 C063002 CTD increases(expression) KIF2C C063002 CTD increases(expression) KRT19 C063002 CTD increases(expression) LGALS1 C063002 CTD increases(expression) MAD2L1 C063002 CTD increases(expression) MAFF C063002 CTD increases(expression) MAPRE2 C063002 CTD increases(expression) MCM2 C063002 CTD decreases(expression) MGAT2 C063002 CTD increases(expression) MXRA7 C063002 CTD increases(expression) NCAPG C063002 CTD decreases(expression) NEDD9 C063002 CTD increases(expression) NEK2 C063002 CTD decreases(expression) NEK4 C063002 CTD decreases(response to substance) NFE2L2 C063002 CTD increases(expression) NOLC1 C063002 CTD decreases(expression) NUCB2 C063002 CTD increases(expression) NUP107 C063002 CTD increases(expression) NUSAP1 C063002 CTD decreases(expression) OS9 C063002 CTD increases(expression) PAK3 C063002 CTD increases(expression) PBK C063002 CTD decreases(expression) PGC C063002 CTD decreases(expression) PGF C063002 CTD increases(expression) PLK1 C063002 CTD increases(expression) POLE2 C063002 CTD increases(expression) PPIH C063002 CTD decreases(expression) PSPH C063002 CTD increases(expression) PTTG1 C063002 CTD increases(expression) RACGAP1 C063002 CTD decreases(expression) RAD23B C063002 CTD increases(expression) RAD51C C063002 CTD increases(expression) RBBP8 C063002 CTD increases(expression) RBPMS C063002 CTD decreases(expression) RECQL C063002 CTD increases(expression) RFC2 C063002 CTD increases(expression) RFC4 C063002 CTD increases(expression) RNASEH2A C063002 CTD increases(expression) RUVBL2 C063002 CTD decreases(expression) SCD C063002 CTD decreases(expression) SERPINA5 C063002 CTD decreases(expression) SERPINA6 C063002 CTD decreases(expression) SERPINB1 C063002 CTD decreases(expression) SERPINC1 C063002 CTD increases(expression) SFN C063002 CTD increases(expression) SHC1 C063002 CTD decreases(expression) SLC1A2 C063002 CTD increases(expression) SMC4 C063002 CTD increases(expression) SNRPA C063002 CTD increases(expression) SPAG5 C063002 CTD increases(expression) SPP1 C063002 CTD increases(expression) SQRDL C063002 CTD increases(expression) SRSF2 C063002 CTD increases(expression) SRSF7 C063002 CTD decreases(expression) ST6GALNAC4 C063002 CTD increases(expression) TIMP1 C063002 CTD decreases(expression) TMED2 C063002 CTD increases(expression) TNFAIP3 C063002 CTD increases(expression) TNFAIP8 C063002 CTD decreases(expression) TNFSF10 C063002 CTD increases(expression) TPX2 C063002 CTD increases(expression) TRIP13 C063002 CTD decreases(expression) TSPAN7 C063002 CTD decreases(expression) TST C063002 CTD increases(expression) TUBA1A C063002 CTD increases(expression) TXNRD1 C063002 CTD increases(expression) TYMS C063002 CTD increases(expression) UBE2C C063002 CTD increases(expression) UBE2V2 C063002 CTD decreases(expression) VTN C063002 CTD increases(expression) ZW10 C063002 CTD increases(expression) ZWINT C063002 PubChem Potency uM 14.125 ALDH1A1 - GI(Protien) : PubChem None uM CYP1A2 - GI(Protien) : PubChem None uM CYP1A2 - GI(Protien) : PubChem Potency uM 19.953 CYP3A4 - GI(Protien) : PubChem None uM CYP3A4 - GI(Protien) : PubChem Potency uM 19.953 EHMT2 - GI(Protien) : PubChem Potency uM 10.000 GLS - GI(Protien) : PubChem Potency uM 7.943 HIF1A - GI(Protien) : PubChem None uM HSP90AA1 - GI(Protien) : PubChem Potency uM 12.589 MAPT - GI(Protien) : PubChem Potency uM 28.184 POLB - GI(Protien) : PubChem Potency uM 12.589 POLI - GI(Protien) : PubChem Potency uM 22.387 POLI - GI(Protien) : PubChem Potency uM 7.943 TDP1 - GI(Protien) : PubChem Potency uM 8.912 TDP1 - GI(Protien) : PubChem Potency uM 3.981 THPO - GI(Protien) : PubChem Potency uM 3.981 TP53 - GI(Protien) : PubChem Potency uM 6.310 TP53 - GI(Protien) : PubChem Potency uM 17.783 USP1 - GI(Protien) : PubChem Potency uM 29.620 USP1 - GI(Protien) : PubChem Potency uM 35.481 VDR - GI(Protien) : ChEMBL Potency nM 14125.400 ALDH1A1 - Target : CHEMBL3577 ChEMBL AC50 nM 3981.070 CYP1A2 - Target : CHEMBL3356 ChEMBL Potency nM 19952.600 CYP3A4 - Target : CHEMBL340 ChEMBL AC50 nM 19952.600 CYP3A4 - Target : CHEMBL340 ChEMBL Potency nM 19952.600 EHMT2 - Target : CHEMBL6032 ChEMBL Potency nM 7943.300 HIF1A - Target : CHEMBL4261 ChEMBL Potency nM 11220.200 KDM4E - Target : CHEMBL1293226 ChEMBL Potency nM 12589.300 MAPT - Target : CHEMBL1293224 ChEMBL Potency nM 28183.800 POLB - Target : CHEMBL2392 ChEMBL Potency nM 3981.100 THPO - Target : CHEMBL1293256 ChEMBL Potency nM 6309.600 TP53 - Target : CHEMBL4096 ChEMBL Potency nM 3981.100 TP53 - Target : CHEMBL4096
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