Tan Lab | DSigDB

Gene Set: D4 : CTD - tyrphostin A23

Collection

D4 : CTD

Chemical Name

tyrphostin A23 ( From PubChem : TYRPHOSTIN 23 )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
186.167 g/mol	2	4	1.52836	True

Structure

InChI

InChI=1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H

InChIKey

VTJXFTPMFYAJJU-UHFFFAOYSA-N

Links

Gene (26 / 60)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			AR		C060641
CTD	increases(activity)			AR		C060641
CTD	increases(reaction)			AR		C060641
PubChem	Potency	uM	10.000	ALDH1A1	-	GI(Protien) :
PubChem	Potency	uM	11.220	ALDH1A1	-	GI(Protien) :
PubChem	Potency	uM	22.387	ALDH1A1	-	GI(Protien) :
PubChem	IC50_Mean	uM	9.970	ALPL	-	GI(Protien) :
PubChem	Potency	uM	79.433	BAZ2B	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	7.943	CYP2C9	-	GI(Protien) :
PubChem	None	uM		CYP2C9	-	GI(Protien) :
PubChem	Potency	uM	31.623	CYP3A4	-	GI(Protien) :
PubChem	None	uM		CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	8.437	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	8.912	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	35.481	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	18.888	FEN1	-	GI(Protien) :
PubChem	Potency	uM	18.888	FEN1	-	GI(Protien) :
PubChem	None	uM		GFER	-	GI(Protien) :
PubChem	Potency	uM	0.355	GLS	-	GI(Protien) :
PubChem	Potency	uM	31.623	HPGD	-	GI(Protien) :
PubChem	Potency	uM	35.481	HPGD	-	GI(Protien) :
PubChem	None	uM		HSP90AA1	-	GI(Protien) :
PubChem	irf1 Inhibition [Ba/F3 cells] (IC50)	uM	0.240	JAK2	-	GI(Protien) :
PubChem	Potency	uM	22.387	L3MBTL1	-	GI(Protien) :
PubChem	Potency	uM	14.125	MAPT	-	GI(Protien) :
PubChem	Potency	uM	11.220	NFKB1	-	GI(Protien) :
PubChem	Potency	uM	7.943	POLH	-	GI(Protien) :
PubChem	Potency	uM	11.220	POLK	-	GI(Protien) :
PubChem	Potency	uM	18.888	RGS4	-	GI(Protien) :
PubChem	Potency	uM	18.837	TDP1	-	GI(Protien) :
PubChem	Potency	uM	21.136	TDP1	-	GI(Protien) :
PubChem	Potency	uM	31.623	VDR	-	GI(Protien) :
PubChem	Potency	uM	50.119	VDR	-	GI(Protien) :
ChEMBL	Potency	nM	22387.200	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	10000.000	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	11220.200	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	12589.300	ALOX15B	-	Target : CHEMBL2457
ChEMBL	IC50	nM	9970.000	ALPL	-	Target : CHEMBL5979
ChEMBL	Potency	nM	79432.800	BAZ2B	-	Target : CHEMBL1741220
ChEMBL	AC50	nM	5011.870	CYP1A2	-	Target : CHEMBL3356
ChEMBL	Potency	nM	7943.300	CYP2C9	-	Target : CHEMBL3397
ChEMBL	AC50	nM	7943.280	CYP2C9	-	Target : CHEMBL3397
ChEMBL	AC50	nM	31622.800	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	31622.800	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	8912.500	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	35481.300	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	8436.800	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	18887.600	FEN1	-	Target : CHEMBL5027
ChEMBL	Potency	nM	35481.300	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	31622.800	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	25118.900	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Activity	um	0.240	JAK2	-	Target : CHEMBL2971
ChEMBL	AC50	nM	10810.000	KDM4C	-	Target : CHEMBL6175
ChEMBL	Potency	nM	1995.300	KDM4E	-	Target : CHEMBL1293226
ChEMBL	Potency	nM	7943.300	KDM4E	-	Target : CHEMBL1293226
ChEMBL	Potency	nM	22387.200	L3MBTL1	-	Target : CHEMBL1287622
ChEMBL	Potency	nM	14125.400	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	11220.200	NFKB1	-	Target : CHEMBL3251

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