Tan Lab | DSigDB

Gene Set: D4 : CTD - sanguinarine

Collection

D4 : CTD

Chemical Name

sanguinarine ( From PubChem : SANGUINARINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
332.329 g/mol	0	4	3.4281	True

Structure

InChI

InChI=1S/C20H14NO4/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21/h2-8H,9-10H2,1H3/q+1

InChIKey

INVGWHRKADIJHF-UHFFFAOYSA-N

Links

Gene (66 / 151)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(binding)			AHR		C005705
CTD	increases(reaction)			AHR		C005705
CTD	affects(localization)			AHR		C005705
CTD	increases(activity)			AHR		C005705
CTD	increases(localization)			AHR		C005705
CTD	affects(binding)			ARNT		C005705
CTD	increases(reaction)			ARNT		C005705
CTD	increases(expression)			BAX		C005705
CTD	decreases(expression)			BCL2		C005705
CTD	decreases(expression)			BCL2		C005705
CTD	increases(chemical synthesis)			BCL2		C005705
CTD	decreases(abundance)			BID		C005705
CTD	decreases(reaction)			BID		C005705
CTD	increases(cleavage)			BID		C005705
CTD	decreases(expression)			BIRC2		C005705
CTD	increases(chemical synthesis)			BIRC2		C005705
CTD	decreases(expression)			CASP3		C005705
CTD	increases(activity)			CASP3		C005705
CTD	increases(activity)			CASP3		C005705
CTD	increases(chemical synthesis)			CASP3		C005705
CTD	increases(activity)			CASP8		C005705
CTD	decreases(expression)			CASP9		C005705
CTD	increases(activity)			CASP9		C005705
CTD	increases(activity)			CASP9		C005705
CTD	increases(chemical synthesis)			CASP9		C005705
CTD	decreases(expression)			CLDN2		C005705
CTD	decreases(expression)			CLDN3		C005705
CTD	decreases(expression)			CLDN4		C005705
CTD	decreases(expression)			CLDN5		C005705
CTD	decreases(activity)			CYP1A1		C005705
CTD	increases(activity)			CYP1A1		C005705
CTD	increases(expression)			CYP1A1		C005705
CTD	increases(activity)			CYP1B1		C005705
CTD	increases(expression)			CYP1B1		C005705
CTD	increases(activity)			EGR1		C005705
CTD	increases(reaction)			EGR1		C005705
CTD	decreases(expression)			EGR1		C005705
CTD	increases(expression)			EGR1		C005705
CTD	decreases(reaction)			GSTA3		C005705
CTD	increases(metabolic processing)			GSTA3		C005705
CTD	decreases(reaction)			GSTP1		C005705
CTD	increases(metabolic processing)			GSTP1		C005705
CTD	decreases(reaction)			GSTP1		C005705
CTD	increases(expression)			GSTP1		C005705
CTD	decreases(reaction)			MAPK1		C005705
CTD	increases(phosphorylation)			MAPK1		C005705
CTD	decreases(reaction)			MAPK3		C005705
CTD	increases(phosphorylation)			MAPK3		C005705
CTD	decreases(reaction)			MAPK8		C005705
CTD	increases(phosphorylation)			MAPK8		C005705
CTD	decreases(reaction)			MAPK9		C005705
CTD	increases(phosphorylation)			MAPK9		C005705
CTD	decreases(expression)			MMP2		C005705
CTD	decreases(expression)			MMP9		C005705
CTD	decreases(expression)			NQO1		C005705
CTD	decreases(expression)			SNAI1		C005705
CTD	decreases(reaction)			TNF		C005705
CTD	increases(expression)			TNF		C005705
CTD	decreases(expression)			XIAP		C005705
CTD	increases(chemical synthesis)			XIAP		C005705
PubChem	AhR Potency (uM)	uM	5.516	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	6.682	AHR	-	GI(Protien) :
PubChem	Potency	uM	12.589	ALOX12	-	GI(Protien) :
PubChem	Potency	uM	3.162	ALOX15	-	GI(Protien) :
PubChem	Potency	uM	7.943	ALOX15	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	18.834	AR	-	GI(Protien) :
PubChem	Potency	uM	1.995	ATXN2	-	GI(Protien) :
PubChem	Potency	uM	5.623	ATXN2	-	GI(Protien) :
PubChem	Potency	uM	6.310	ATXN2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	11.883	CYP19A1	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	6.310	CYP2C19	-	GI(Protien) :
PubChem	None	uM		CYP2C19	-	GI(Protien) :
PubChem	Potency	uM	3.162	CYP3A4	-	GI(Protien) :
PubChem	None	uM		CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	1.889	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	12.589	EHMT2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	10.672	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	15.089	ESR1	-	GI(Protien) :
PubChem	None	uM		GAPDH	-	GI(Protien) :
PubChem	Potency	uM	3.162	GLS	-	GI(Protien) :
PubChem	Potency	uM	12.589	GNAI1	-	GI(Protien) :
PubChem	None	uM		GNAI1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	4.269	HSPB1	-	GI(Protien) :
PubChem	Potency	uM	6.310	HTT	-	GI(Protien) :
PubChem	Potency	uM	15.849	KAT2A	-	GI(Protien) :
PubChem	Potency	uM	25.119	MAPK1	-	GI(Protien) :
PubChem	Potency	uM	25.119	MAPK1	-	GI(Protien) :
PubChem	Potency	uM	28.184	MAPT	-	GI(Protien) :
PubChem	None	uM		NCOA2	-	GI(Protien) :
PubChem	None	uM		NCOA2	-	GI(Protien) :
PubChem	Potency	uM	10.000	NFKB1	-	GI(Protien) :
PubChem	None	uM		NR2F2	-	GI(Protien) :
PubChem	None	uM		NR2F2	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
PubChem	None	uM		PAX8	-	GI(Protien) :
PubChem	Potency	uM	10.000	PKM	-	GI(Protien) :
PubChem	None	uM		PLA2G3	-	GI(Protien) :
PubChem	None	uM		PLA2G3	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	2.592	PPARD	-	GI(Protien) :
PubChem	None	uM		PRMT1	-	GI(Protien) :
PubChem	None	uM		PRMT1	-	GI(Protien) :
PubChem	None	uM		PRNP	-	GI(Protien) :
PubChem	None	uM		PRNP	-	GI(Protien) :
PubChem	None	uM		PRNP	-	GI(Protien) :
PubChem	Potency	uM	12.589	RGS12	-	GI(Protien) :
PubChem	Potency	uM	25.119	RGS12	-	GI(Protien) :
PubChem	None	uM		RGS12	-	GI(Protien) :
PubChem	Potency	uM	2.119	RGS4	-	GI(Protien) :
PubChem	Potency	uM	2.512	SMAD3	-	GI(Protien) :
PubChem	Potency	uM	10.000	STAT6	-	GI(Protien) :
PubChem	Potency	uM	0.581	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.820	TDP1	-	GI(Protien) :
PubChem	Potency	uM	1.000	THPO	-	GI(Protien) :
PubChem	Potency	uM	2.512	TP53	-	GI(Protien) :
PubChem	Potency	uM	3.162	TP53	-	GI(Protien) :
PubChem	Potency	uM	6.310	TP53	-	GI(Protien) :
PubChem	None	uM		TRA	-	GI(Protien) :
PubChem	None	uM		TRA	-	GI(Protien) :
PubChem	Potency	uM	2.818	VDR	-	GI(Protien) :
PubChem	Potency	uM	7.943	VDR	-	GI(Protien) :
PubChem	Potency	uM	35.481	VDR	-	GI(Protien) :
ChEMBL	Potency	nM	12589.300	ALOX12	-	Target : CHEMBL3687
ChEMBL	Potency	nM	7943.300	ALOX15	-	Target : CHEMBL2903
ChEMBL	Potency	nM	3162.300	ALOX15	-	Target : CHEMBL2903
ChEMBL	Potency	nM	3981.100	ALOX15B	-	Target : CHEMBL2457
ChEMBL	AC50	nM	10000.000	CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	3981.070	CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	6309.570	CYP2C19	-	Target : CHEMBL3622
ChEMBL	Potency	nM	6309.600	CYP2C19	-	Target : CHEMBL3622
ChEMBL	Potency	nM	3162.300	CYP3A4	-	Target : CHEMBL340
ChEMBL	AC50	nM	3162.280	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	12589.300	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	1888.800	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	12589.300	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	3981.100	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	6309.600	HTT	-	Target : CHEMBL5514
ChEMBL	Potency	nM	15848.900	KAT2A	-	Target : CHEMBL5501
ChEMBL	Potency	nM	25118.900	MAPK1	-	Target : CHEMBL4040
ChEMBL	Potency	nM	25118.900	MAPK1	-	Target : CHEMBL4040
ChEMBL	Potency	nM	17782.800	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	28183.800	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	10000.000	NFKB1	-	Target : CHEMBL3251
ChEMBL	Potency	nM	10000.000	PKM	-	Target : CHEMBL1075189
ChEMBL	Potency	nM	25118.900	RGS12	-	Target : CHEMBL1293276
ChEMBL	Potency	nM	10000.000	STAT6	-	Target : CHEMBL5401
ChEMBL	Potency	nM	1000.000	THPO	-	Target : CHEMBL1293256
ChEMBL	Potency	nM	6309.600	TP53	-	Target : CHEMBL4096
ChEMBL	Potency	nM	3162.300	TP53	-	Target : CHEMBL4096
ChEMBL	Potency	nM	2511.900	TP53	-	Target : CHEMBL4096

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