Tan Lab | DSigDB

Gene Set: D4 : CTD - jasplakinolide

Collection

D4 : CTD

Chemical Name

jasplakinolide ( From PubChem : JASPLAKINOLIDE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
709.67 g/mol	4	9	6.2973	False(2/4)

Structure

InChI

InChI=1S/C36H45BrN4O6/c1-20-15-21(2)17-23(4)47-32(43)19-30(25-11-13-26(42)14-12-25)40-35(45)31(18-28-27-9-7-8-10-29(27)39-33(28)37)41(6)36(46)24(5)38-34(44)22(3)16-20/h7-15,21-24,30-31,39,42H,16-19H2,1-6H3,(H,38,44)(H,40,45)

InChIKey

GQWYWHOHRVVHAP-UHFFFAOYSA-N

Links

Gene (24 / 47)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			CDH5		C057531
CTD	increases(uptake)			CDH5		C057531
CTD	increases(expression)			GDF15		C057531
CTD	affects(cotreatment)			GDF15		C057531
CTD	decreases(reaction)			GDF15		C057531
CTD	affects(localization)			ICAM1		C057531
CTD	decreases(reaction)			ICAM1		C057531
CTD	affects(cotreatment)			IFNG		C057531
CTD	increases(expression)			IFNG		C057531
CTD	increases(reaction)			IFNG		C057531
CTD	affects(cotreatment)			IL1B		C057531
CTD	increases(expression)			IL1B		C057531
CTD	increases(reaction)			IL1B		C057531
CTD	affects(cotreatment)			NOS2		C057531
CTD	increases(expression)			NOS2		C057531
CTD	increases(reaction)			NOS2		C057531
CTD	decreases(secretion)			RS1		C057531
CTD	decreases(expression)			SPP1		C057531
CTD	affects(localization)			TNF		C057531
CTD	decreases(reaction)			TNF		C057531
CTD	affects(cotreatment)			TNF		C057531
CTD	increases(expression)			TNF		C057531
CTD	increases(reaction)			TNF		C057531
CTD	affects(localization)			VCAM1		C057531
CTD	decreases(reaction)			VCAM1		C057531
PubChem	None	uM		ADAM10	-	GI(Protien) :
PubChem	None	uM		ADAM10	-	GI(Protien) :
PubChem	None	uM		ADAM17	-	GI(Protien) :
PubChem	None	uM		ADAM17	-	GI(Protien) :
PubChem	None	uM		ADRB2	-	GI(Protien) :
PubChem	Potency	uM	0.015	ATXN2	-	GI(Protien) :
PubChem	None	uM		CFTR	-	GI(Protien) :
PubChem	Potency	uM	0.116	GMNN	-	GI(Protien) :
PubChem	AC50_uM	uM	4.094	HSP90AA1	-	GI(Protien) :
PubChem	Potency	uM	1.300	IDH1	-	GI(Protien) :
PubChem	None	uM		MITF	-	GI(Protien) :
PubChem	Potency	uM	0.581	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	1.458	NFE2L2	-	GI(Protien) :
PubChem	AC50_uM	uM	0.260	PAX8	-	GI(Protien) :
PubChem	None	uM		PAX8	-	GI(Protien) :
PubChem	None	uM		PRNP	-	GI(Protien) :
PubChem	None	uM		PRNP	-	GI(Protien) :
PubChem	None	uM		PRNP	-	GI(Protien) :
PubChem	Potency	uM	0.259	SMAD3	-	GI(Protien) :
PubChem	Potency	uM	15.849	SMAD3	-	GI(Protien) :
PubChem	Potency	uM	0.015	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.026	TDP1	-	GI(Protien) :

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