Tan Lab | DSigDB

Gene Set: D4 : CTD - exemestane

Collection

D4 : CTD

Chemical Name

exemestane ( From PubChem : EXEMESTANE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
296.403 g/mol	0	2	4.0295	True

Structure

InChI

InChI=1S/C20H24O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16H,1,4-5,7,9-10H2,2-3H3/t14-,15-,16-,19+,20-/m0/s1

InChIKey

BFYIZQONLCFLEV-DAELLWKTSA-N

Links

Gene (37 / 47)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			ABCG4		C056516
CTD	increases(expression)			ADCYAP1R1		C056516
CTD	increases(expression)			AREG		C056516
CTD	increases(expression)			C20ORF194		C056516
CTD	increases(expression)			CD83		C056516
CTD	decreases(activity)			CYP19A1		C056516
CTD	increases(expression)			DAB2		C056516
CTD	increases(expression)			EBF1		C056516
CTD	affects(binding)			ESR1		C056516
CTD	decreases(reaction)			ESR1		C056516
CTD	increases(activity)			ESR1		C056516
CTD	increases(expression)			GPC2		C056516
CTD	increases(expression)			HOXD11		C056516
CTD	increases(expression)			INPP5K		C056516
CTD	increases(expression)			INTS4		C056516
CTD	increases(expression)			KIF13B		C056516
CTD	increases(expression)			KLK7		C056516
CTD	increases(expression)			METRN		C056516
CTD	decreases(expression)			MKI67		C056516
CTD	increases(expression)			MYBL2		C056516
CTD	increases(expression)			MYO9B		C056516
CTD	increases(expression)			OSTM1		C056516
CTD	decreases(expression)			PGR		C056516
CTD	increases(expression)			PGR		C056516
CTD	increases(expression)			PLCG2		C056516
CTD	increases(expression)			RNF123		C056516
CTD	increases(expression)			RRP12		C056516
CTD	increases(expression)			SLC13A4		C056516
CTD	decreases(reaction)			SLC22A2		C056516
CTD	increases(uptake)			SLC22A2		C056516
CTD	increases(expression)			SNHG20		C056516
CTD	increases(expression)			TBC1D17		C056516
CTD	increases(expression)			TFF1		C056516
CTD	increases(expression)			TMEM155		C056516
CTD	increases(expression)			TNFRSF14		C056516
CTD	increases(expression)			TP53TG1		C056516
CTD	increases(expression)			TRIOBP		C056516
CTD	increases(expression)			XIST		C056516
PubChem	Potency-Replicate_1	uM	0.030	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.601	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.042	CYP19A1	-	GI(Protien) :
PubChem	None	uM		CYP19A1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	8.413	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	2.033	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	2.660	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	8.414	TDP1	-	GI(Protien) :
PubChem	Potency	uM	16.360	TDP1	-	GI(Protien) :

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