Tan Lab | DSigDB

Gene Set: D4 : CTD - gemcitabine

Collection

D4 : CTD

Chemical Name

gemcitabine ( From PubChem : GEMCITABINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Approved	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
263.198 g/mol	3	7	-0.7074	True

Structure

InChI

InChI=1S/C9H11F2N3O4/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17)/t4-,6-,7-/m1/s1

InChIKey

SDUQYLNIPVEERB-QPPQHZFASA-N

Links

Gene (235 / 368)

⊖ Less

Source	Type	Gene	Other
CTD	increases(expression)	A2M	C056507
CTD	decreases(expression)	ACPP	C056507
CTD	increases(cleavage)	ADAM17	C056507
CTD	increases(reaction)	ADAM17	C056507
CTD	increases(expression)	ADIPOQ	C056507
CTD	decreases(expression)	AFP	C056507
CTD	decreases(expression)	AGPAT2	C056507
CTD	affects(response to substance)	AKT1	C056507
CTD	decreases(expression)	ALDH1A1	C056507
CTD	increases(reaction)	ALDH1A1	C056507
CTD	increases(expression)	ALDH1A3	C056507
CTD	increases(expression)	ALDH6A1	C056507
CTD	increases(expression)	ANAPC1	C056507
CTD	increases(expression)	ANK3	C056507
CTD	increases(expression)	ANKRD1	C056507
CTD	affects(expression)	ANTXR1	C056507
CTD	decreases(expression)	APCS	C056507
CTD	increases(expression)	APOH	C056507
CTD	increases(cleavage)	AREG	C056507
CTD	increases(reaction)	AREG	C056507
CTD	decreases(response to substance)	AREG	C056507
CTD	increases(expression)	AREG	C056507
CTD	decreases(expression)	ARF1	C056507
CTD	increases(expression)	ATF3	C056507
CTD	affects(cotreatment)	BAX	C056507
CTD	increases(expression)	BAX	C056507
CTD	affects(cotreatment)	BAX	C056507
CTD	increases(expression)	BAX	C056507
CTD	affects(cotreatment)	BAX	C056507
CTD	increases(expression)	BAX	C056507
CTD	affects(cotreatment)	BAX	C056507
CTD	affects(localization)	BAX	C056507
CTD	affects(cotreatment)	BCL2	C056507
CTD	decreases(expression)	BCL2	C056507
CTD	affects(cotreatment)	BCL2	C056507
CTD	decreases(expression)	BCL2	C056507
CTD	decreases(expression)	BCL2	C056507
CTD	decreases(reaction)	BCL2	C056507
CTD	decreases(expression)	BCL2	C056507
CTD	affects(cotreatment)	BCL2	C056507
CTD	decreases(expression)	BCL2	C056507
CTD	affects(cotreatment)	BCL2	C056507
CTD	decreases(expression)	BCL2	C056507
CTD	decreases(reaction)	BCL2	C056507
CTD	affects(expression)	BCL2L1	C056507
CTD	decreases(reaction)	BCL2L1	C056507
CTD	decreases(expression)	BCL2L1	C056507
CTD	increases(expression)	BCL2L11	C056507
CTD	increases(expression)	BCL6	C056507
CTD	decreases(expression)	BDNF	C056507
CTD	increases(cleavage)	BID	C056507
CTD	increases(expression)	BIRC2	C056507
CTD	affects(expression)	BIRC3	C056507
CTD	decreases(expression)	BIRC5	C056507
CTD	decreases(reaction)	BIRC5	C056507
CTD	increases(expression)	BNIP3L	C056507
CTD	affects(cotreatment)	CASP3	C056507
CTD	increases(cleavage)	CASP3	C056507
CTD	affects(cotreatment)	CASP3	C056507
CTD	increases(expression)	CASP3	C056507
CTD	affects(activity)	CASP3	C056507
CTD	affects(cotreatment)	CASP3	C056507
CTD	increases(activity)	CASP3	C056507
CTD	increases(cleavage)	CASP3	C056507
CTD	decreases(reaction)	CASP3	C056507
CTD	increases(activity)	CASP3	C056507
CTD	affects(cotreatment)	CASP3	C056507
CTD	increases(activity)	CASP3	C056507
CTD	affects(cotreatment)	CASP6	C056507
CTD	increases(expression)	CASP6	C056507
CTD	affects(cotreatment)	CASP8	C056507
CTD	increases(expression)	CASP8	C056507
CTD	affects(activity)	CASP8	C056507
CTD	affects(cotreatment)	CASP8	C056507
CTD	increases(activity)	CASP8	C056507
CTD	increases(cleavage)	CASP8	C056507
CTD	affects(cotreatment)	CASP8	C056507
CTD	increases(activity)	CASP8	C056507
CTD	affects(cotreatment)	CASP9	C056507
CTD	increases(expression)	CASP9	C056507
CTD	increases(activity)	CASP9	C056507
CTD	increases(cleavage)	CASP9	C056507
CTD	decreases(reaction)	CASP9	C056507
CTD	increases(activity)	CASP9	C056507
CTD	decreases(expression)	CCL2	C056507
CTD	increases(expression)	CCL20	C056507
CTD	increases(expression)	CCL3	C056507
CTD	increases(expression)	CCNB1	C056507
CTD	decreases(expression)	CCND1	C056507
CTD	increases(reaction)	CCND1	C056507
CTD	decreases(expression)	CCND1	C056507
CTD	increases(expression)	CCNG2	C056507
CTD	decreases(expression)	CD40	C056507
CTD	decreases(expression)	CD40	C056507
CTD	decreases(expression)	CD40LG	C056507
CTD	affects(response to substance)	CDA	C056507
CTD	affects(cotreatment)	CDA	C056507
CTD	decreases(expression)	CDA	C056507
CTD	increases(response to substance)	CDA	C056507
CTD	increases(expression)	CDH1	C056507
CTD	affects(cotreatment)	CDKN1A	C056507
CTD	increases(expression)	CDKN1A	C056507
CTD	increases(expression)	CDKN1A	C056507
CTD	increases(expression)	CDKN1A	C056507
CTD	decreases(reaction)	CDKN1A	C056507
CTD	increases(expression)	CDKN1A	C056507
CTD	decreases(response to substance)	CDKN1B	C056507
CTD	increases(expression)	CEBPB	C056507
CTD	decreases(expression)	CKB	C056507
CTD	increases(expression)	CLIC4	C056507
CTD	affects(response to substance)	CLU	C056507
CTD	increases(expression)	CLU	C056507
CTD	decreases(reaction)	CNR1	C056507
CTD	increases(expression)	CNR1	C056507
CTD	decreases(reaction)	CNR2	C056507
CTD	increases(expression)	CNR2	C056507
CTD	decreases(response to substance)	COX3	C056507
CTD	decreases(reaction)	COX3	C056507
CTD	decreases(expression)	CSF2	C056507
CTD	decreases(expression)	CSF3	C056507
CTD	increases(expression)	CSRP2	C056507
CTD	increases(expression)	CTHRC1	C056507
CTD	increases(expression)	CXCL1	C056507
CTD	increases(expression)	CXCL2	C056507
CTD	increases(expression)	CXCL3	C056507
CTD	decreases(expression)	CXCL8	C056507
CTD	decreases(expression)	CYP24A1	C056507
CTD	affects(expression)	DDIT4	C056507
CTD	decreases(expression)	DHX9	C056507
CTD	increases(expression)	DLG2	C056507
CTD	affects(cotreatment)	DPYD	C056507
CTD	affects(response to substance)	DPYD	C056507
CTD	decreases(expression)	DYNC1H1	C056507
CTD	decreases(expression)	EDN1	C056507
CTD	decreases(expression)	EDN2	C056507
CTD	decreases(reaction)	EGF	C056507
CTD	decreases(response to substance)	EGF	C056507
CTD	increases(reaction)	EGF	C056507
CTD	decreases(expression)	EGF	C056507
CTD	decreases(reaction)	EGFR	C056507
CTD	increases(degradation)	EGFR	C056507
CTD	increases(phosphorylation)	EGFR	C056507
CTD	affects(cotreatment)	EGFR	C056507
CTD	increases(response to substance)	EGFR	C056507
CTD	affects(binding)	EGFR	C056507
CTD	increases(reaction)	EGFR	C056507
CTD	decreases(expression)	EGFR	C056507
CTD	increases(expression)	EGFR	C056507
CTD	increases(phosphorylation)	EGFR	C056507
CTD	increases(expression)	EGR1	C056507
CTD	affects(binding)	ERBB3	C056507
CTD	increases(reaction)	ERBB3	C056507
CTD	increases(phosphorylation)	ERBB3	C056507
CTD	increases(expression)	ETV1	C056507
CTD	decreases(expression)	EVI2B	C056507
CTD	decreases(expression)	F7	C056507
CTD	decreases(expression)	FAM198B	C056507
CTD	increases(expression)	FAS	C056507
CTD	increases(expression)	FAS	C056507
CTD	increases(expression)	FBXO25	C056507
CTD	affects(cotreatment)	FGF2	C056507
CTD	increases(expression)	FGF2	C056507
CTD	increases(expression)	FGF2	C056507
CTD	affects(expression)	FGG	C056507
CTD	decreases(expression)	FOSL2	C056507
CTD	increases(expression)	FXYD3	C056507
CTD	decreases(expression)	GAL3ST1	C056507
CTD	decreases(expression)	GAS1	C056507
CTD	increases(expression)	GLRX	C056507
CTD	increases(expression)	GPC3	C056507
CTD	increases(phosphorylation)	GSK3B	C056507
CTD	affects(expression)	GTF2A1	C056507
CTD	increases(expression)	HDAC9	C056507
CTD	affects(response to substance)	HIF1A	C056507
CTD	decreases(expression)	HIST1H4B	C056507
CTD	decreases(expression)	HIST1H4C	C056507
CTD	increases(expression)	HOXB2	C056507
CTD	decreases(expression)	HSPA1L	C056507
CTD	increases(expression)	HSPA5	C056507
CTD	decreases(expression)	ICAM1	C056507
CTD	increases(expression)	IFIT1	C056507
CTD	affects(cotreatment)	IFNA2	C056507
CTD	increases(expression)	IFNA2	C056507
CTD	decreases(expression)	IFNG	C056507
CTD	decreases(expression)	IL10	C056507
CTD	increases(expression)	IL13	C056507
CTD	decreases(expression)	IL15	C056507
CTD	increases(expression)	IL16	C056507
CTD	decreases(expression)	IL1A	C056507
CTD	decreases(expression)	IL1B	C056507
CTD	decreases(expression)	IL4	C056507
CTD	decreases(expression)	IL6	C056507
CTD	increases(expression)	IL6	C056507
CTD	affects(response to substance)	ILK	C056507
CTD	increases(expression)	INS	C056507
CTD	increases(expression)	INSIG1	C056507
CTD	increases(expression)	IQGAP1	C056507
CTD	increases(expression)	IRAK2	C056507
CTD	decreases(expression)	IRF3	C056507
CTD	affects(cotreatment)	ITGAV	C056507
CTD	affects(response to substance)	ITGAV	C056507
CTD	affects(cotreatment)	ITGB6	C056507
CTD	affects(response to substance)	ITGB6	C056507
CTD	increases(expression)	ITSN2	C056507
CTD	decreases(expression)	JAM3	C056507
CTD	decreases(expression)	KCTD12	C056507
CTD	decreases(expression)	KITLG	C056507
CTD	increases(expression)	KLF8	C056507
CTD	decreases(expression)	KRT8	C056507
CTD	increases(expression)	LARP4B	C056507
CTD	decreases(expression)	LEP	C056507
CTD	increases(expression)	LIFR	C056507
CTD	decreases(expression)	LPAR6	C056507
CTD	increases(expression)	LRRC28	C056507
CTD	increases(expression)	LTA	C056507
CTD	decreases(expression)	LYZ	C056507
CTD	increases(expression)	MAF	C056507
CTD	decreases(expression)	MAGEA10	C056507
CTD	increases(expression)	MAGEC1	C056507
CTD	increases(expression)	MAGI1	C056507
CTD	increases(phosphorylation)	MAP2K3	C056507
CTD	increases(phosphorylation)	MAP2K6	C056507
CTD	increases(phosphorylation)	MAPK1	C056507
CTD	increases(phosphorylation)	MAPK3	C056507
CTD	increases(expression)	MARCKS	C056507
CTD	increases(phosphorylation)	MARCKS	C056507
CTD	increases(expression)	MARS	C056507
CTD	increases(expression)	MDM2	C056507
CTD	decreases(expression)	MGMT	C056507
CTD	decreases(expression)	MMP3	C056507
CTD	affects(cotreatment)	MMP9	C056507
CTD	increases(expression)	MMP9	C056507
CTD	increases(expression)	MPO	C056507
CTD	increases(expression)	MXI1	C056507
CTD	increases(expression)	MYB	C056507
CTD	increases(expression)	NCBP1	C056507
CTD	increases(expression)	NEDD9	C056507
CTD	increases(expression)	NEU1	C056507
CTD	decreases(response to substance)	NFE2L2	C056507
CTD	affects(expression)	NFKB2	C056507
CTD	affects(cotreatment)	NFKBIA	C056507
CTD	increases(expression)	NFKBIA	C056507
CTD	affects(expression)	NFKBIE	C056507
CTD	increases(expression)	NNMT	C056507
CTD	increases(expression)	NOTCH1	C056507
CTD	decreases(reaction)	NOTCH1	C056507
CTD	decreases(expression)	NPEPPS	C056507
CTD	increases(expression)	NR4A3	C056507
CTD	increases(expression)	NRG1	C056507
CTD	decreases(response to substance)	NRP1	C056507
CTD	decreases(expression)	NUPR1	C056507
CTD	affects(response to substance)	NUPR1	C056507
CTD	decreases(expression)	PAPPA	C056507
CTD	increases(expression)	PAQR8	C056507
CTD	affects(cotreatment)	PARP1	C056507
CTD	increases(cleavage)	PARP1	C056507
CTD	decreases(reaction)	PARP1	C056507
CTD	increases(cleavage)	PARP1	C056507
CTD	increases(expression)	PCSK9	C056507
CTD	decreases(response to substance)	PDPK1	C056507
CTD	increases(expression)	PDZK1IP1	C056507
CTD	increases(expression)	PJA2	C056507
CTD	increases(expression)	PLAU	C056507
CTD	increases(expression)	PPFIA4	C056507
CTD	increases(expression)	PPP1R15A	C056507
CTD	increases(expression)	PSAT1	C056507
CTD	affects(expression)	PTEN	C056507
CTD	decreases(expression)	PTGS1	C056507
CTD	decreases(response to substance)	PTK2	C056507
CTD	affects(expression)	PTPN11	C056507
CTD	decreases(expression)	RAB8A	C056507
CTD	decreases(response to substance)	RBM17	C056507
CTD	decreases(expression)	REG3A	C056507
CTD	decreases(expression)	REL	C056507
CTD	increases(reaction)	REL	C056507
CTD	affects(cotreatment)	RELA	C056507
CTD	affects(localization)	RELA	C056507
CTD	increases(expression)	RELA	C056507
CTD	increases(expression)	RELA	C056507
CTD	decreases(reaction)	RELA	C056507
CTD	increases(expression)	RGS2	C056507
CTD	increases(expression)	RNF149	C056507
CTD	increases(expression)	RPL37	C056507
CTD	increases(expression)	RRAGD	C056507
CTD	decreases(response to substance)	RRM2	C056507
CTD	increases(expression)	RSL24D1	C056507
CTD	increases(expression)	SAT1	C056507
CTD	increases(expression)	SCD	C056507
CTD	increases(expression)	SLC25A29	C056507
CTD	decreases(reaction)	SLC28A1	C056507
CTD	increases(transport)	SLC28A1	C056507
CTD	decreases(reaction)	SLC29A1	C056507
CTD	increases(uptake)	SLC29A1	C056507
CTD	increases(reaction)	SLC29A1	C056507
CTD	increases(uptake)	SLC29A1	C056507
CTD	increases(expression)	SLC29A1	C056507
CTD	increases(uptake)	SLC29A1	C056507
CTD	increases(response to substance)	SLC29A1	C056507
CTD	affects(response to substance)	SLC29A1	C056507
CTD	decreases(response to substance)	SLC29A1	C056507
CTD	increases(response to substance)	SLC29A1	C056507
CTD	increases(uptake)	SLC29A1	C056507
CTD	affects(transport)	SLC29A3	C056507
CTD	increases(expression)	SLC2A14	C056507
CTD	increases(expression)	SLC2A3	C056507
CTD	decreases(expression)	SLC43A3	C056507
CTD	increases(expression)	SLITRK2	C056507
CTD	decreases(reaction)	SMG1	C056507
CTD	increases(activity)	SMG1	C056507
CTD	decreases(response to substance)	SMG1	C056507
CTD	increases(expression)	SPP1	C056507
CTD	affects(cotreatment)	SRC	C056507
CTD	increases(response to substance)	SRC	C056507
CTD	affects(response to substance)	SRC	C056507
CTD	decreases(response to substance)	SRC	C056507
CTD	decreases(response to substance)	SRC	C056507
CTD	decreases(activity)	STAT3	C056507
CTD	decreases(expression)	SYNCRIP	C056507
CTD	decreases(expression)	SZRD1	C056507
CTD	decreases(expression)	TCOF1	C056507
CTD	affects(cotreatment)	TERT	C056507
CTD	decreases(activity)	TERT	C056507
CTD	affects(cotreatment)	TFAP2A	C056507
CTD	decreases(response to substance)	TFAP2A	C056507
CTD	increases(response to substance)	TFAP2A	C056507
CTD	decreases(reaction)	TGFB1	C056507
CTD	decreases(response to substance)	TGFB1	C056507
CTD	increases(reaction)	TGFB1	C056507
CTD	increases(expression)	TGFB2	C056507
CTD	increases(expression)	THPO	C056507
CTD	affects(expression)	TNF	C056507
CTD	increases(expression)	TNF	C056507
CTD	increases(expression)	TNFAIP3	C056507
CTD	affects(activity)	TNFRSF10B	C056507
CTD	affects(cotreatment)	TNFRSF10B	C056507
CTD	increases(expression)	TNFRSF10B	C056507
CTD	increases(expression)	TNFRSF11B	C056507
CTD	affects(cotreatment)	TNFSF10	C056507
CTD	affects(localization)	TNFSF10	C056507
CTD	increases(activity)	TNFSF10	C056507
CTD	increases(expression)	TP53	C056507
CTD	decreases(reaction)	TP53	C056507
CTD	increases(expression)	TP53	C056507
CTD	affects(cotreatment)	TP53	C056507
CTD	decreases(response to substance)	TP53	C056507
CTD	increases(expression)	TP53BP1	C056507
CTD	increases(expression)	TP53INP1	C056507
CTD	affects(expression)	TRAF1	C056507
CTD	increases(expression)	TUBE1	C056507
CTD	affects(response to substance)	TYMP	C056507
CTD	affects(cotreatment)	TYMP	C056507
CTD	affects(expression)	TYRP1	C056507
CTD	decreases(expression)	UBE2C	C056507
CTD	increases(expression)	UGGT2	C056507
CTD	decreases(expression)	VCAM1	C056507
CTD	increases(expression)	VEGFA	C056507
CTD	decreases(expression)	VGF	C056507
CTD	increases(expression)	VLDLR	C056507
CTD	increases(expression)	VMP1	C056507
CTD	decreases(expression)	VWF	C056507
CTD	increases(expression)	WBP5	C056507
CTD	decreases(expression)	WNT5A	C056507
CTD	increases(expression)	XBP1	C056507
CTD	increases(reaction)	XBP1	C056507
CTD	affects(response to substance)	XIAP	C056507
CTD	increases(expression)	ZNF274	C056507
CTD	increases(expression)	ZNF449	C056507
CTD	decreases(expression)	ZNF521	C056507

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