DSigDB

Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

Home

Search Gene

Collection

Browse

Download

Help

DSigDB Home

Search Gene

Collections

Browse Gene Sets

Download

Help

Gene Set: D4 : CTD - 4-hydroxy-N-desmethyltamoxifen

---

Collection	D4 : CTD
Chemical Name	4-hydroxy-N-desmethyltamoxifen ( From PubChem : (E/Z)-ENDOXIFEN )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 373.487 g/mol 2 3 5.7504 False(3/4)
Structure
InChI	InChI=1S/C25H27NO2/c1-3-24(19-7-5-4-6-8-19)25(20-9-13-22(27)14-10-20)21-11-15-23(16-12-21)28-18-17-26-2/h4-16,26-27H,3,17-18H2,1-2H3/b25-24+
InChIKey	MHJBZVSGOZTKRH-OCOZRVBESA-N
Links
Gene (4 / 15) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD decreases(reaction) AREG C055492 CTD increases(expression) AREG C055492 CTD affects(abundance) CYP2D6 C055492 CTD decreases(abundance) CYP2D6 C055492 CTD decreases(activity) CYP2D6 C055492 CTD decreases(chemical synthesis) CYP2D6 C055492 CTD affects(cotreatment) ESR1 C055492 CTD decreases(reaction) ESR1 C055492 CTD increases(stability) ESR1 C055492 CTD decreases(expression) ESR1 C055492 CTD increases(degradation) ESR1 C055492 CTD decreases(reaction) MYC C055492 CTD increases(expression) MYC C055492 ChEMBL Activity - ESR1 - Target : CHEMBL206 ChEMBL Activity - ESR1 - Target : CHEMBL206
Download gene sets	gmt, text, Detailed text

Contact us
Tan Lab , Mail Stop 8117
12801 East 17th Avenue
Division of Medical Oncology , Department of Medicine
University of Colorado School of Medicine
Aurora, CO 80045, USA

* Best viewed in the latest version of Chrome (42+), Safari (8+), IE (11+) or Firefox (35+).