Tan Lab | DSigDB

Gene Set: D4 : CTD - honokiol

Collection

D4 : CTD

Chemical Name

honokiol ( From PubChem : HONOKIOL )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
266.334 g/mol	2	2	4.2218	True

Structure

InChI

InChI=1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2

InChIKey

FVYXIJYOAGAUQK-UHFFFAOYSA-N

Links

Gene (29 / 56)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(expression)			ALOX15		C005499
CTD	increases(reaction)			ALOX15		C005499
CTD	increases(expression)			ALOX15		C005499
CTD	increases(abundance)			ALOX15		C005499
CTD	increases(expression)			BAX		C005499
CTD	increases(activity)			CASP3		C005499
CTD	increases(activity)			CASP8		C005499
CTD	increases(activity)			CASP9		C005499
CTD	decreases(reaction)			CCL3		C005499
CTD	increases(expression)			CCL3		C005499
CTD	decreases(reaction)			CTGF		C005499
CTD	increases(expression)			CTGF		C005499
CTD	decreases(reaction)			IL18		C005499
CTD	increases(expression)			IL18		C005499
CTD	decreases(reaction)			IL1B		C005499
CTD	increases(expression)			IL1B		C005499
CTD	decreases(activity)			IL4		C005499
CTD	decreases(reaction)			MAPK1		C005499
CTD	increases(phosphorylation)			MAPK1		C005499
CTD	decreases(reaction)			MAPK3		C005499
CTD	increases(phosphorylation)			MAPK3		C005499
CTD	decreases(expression)			MCL1		C005499
CTD	decreases(reaction)			NOS2		C005499
CTD	increases(chemical synthesis)			NOS2		C005499
CTD	increases(expression)			NOS2		C005499
CTD	increases(cleavage)			PARP1		C005499
CTD	decreases(expression)			PPARG		C005499
CTD	increases(reaction)			PPARG		C005499
CTD	affects(binding)			PPARG		C005499
CTD	increases(activity)			PPARG		C005499
CTD	decreases(expression)			PTGS2		C005499
CTD	increases(reaction)			PTGS2		C005499
CTD	decreases(reaction)			PTGS2		C005499
CTD	increases(expression)			PTGS2		C005499
CTD	decreases(reaction)			RELA		C005499
CTD	increases(phosphorylation)			RELA		C005499
CTD	decreases(reaction)			TGFB1		C005499
CTD	increases(expression)			TGFB1		C005499
CTD	decreases(reaction)			TGFB1		C005499
CTD	increases(expression)			TGFB1		C005499
CTD	decreases(reaction)			TNF		C005499
CTD	increases(expression)			TNF		C005499
PubChem	Potency	uM	28.184	ATXN2	-	GI(Protien) :
PubChem	None	uM		CACNA1H	-	GI(Protien) :
PubChem	Potency	uM	35.481	GAA	-	GI(Protien) :
PubChem	None	uM		GFER	-	GI(Protien) :
PubChem	None	uM		KCNK9	-	GI(Protien) :
PubChem	None	uM		KCNK9	-	GI(Protien) :
PubChem	None	uM		KCNK9	-	GI(Protien) :
PubChem	IC50	uM	12.023	SLC5A7	-	GI(Protien) :
PubChem	None	uM		SLC5A7	-	GI(Protien) :
PubChem	None	uM		SLC5A7	-	GI(Protien) :
PubChem	Potency	uM	18.356	TDP1	-	GI(Protien) :
ChEMBL	Activity	-		CNR2	-	Target : CHEMBL253
ChEMBL	Potency	nM	35481.300	GAA	-	Target : CHEMBL2608
ChEMBL	Activity	-		RXRA	-	Target : CHEMBL2061

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