Tan Lab | DSigDB

Gene Set: D4 : CTD - irinotecan

Collection

D4 : CTD

Chemical Name

irinotecan ( From PubChem : IRINOTECAN HYDROCHLORIDE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
623.139 g/mol	2	10	4.7689	False(3/4)

Structure

InChI

InChI=1S/C33H38N4O6.ClH/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;1H/t33-;/m0./s1

InChIKey

GURKHSYORGJETM-WAQYZQTGSA-N

Links

Gene (565 / 799)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(metabolic processing)			ABCB1		C051890
CTD	affects(response to substance)			ABCB1		C051890
CTD	affects(response to substance)			ABCB1		C051890
CTD	affects(export)			ABCB1		C051890
CTD	decreases(response to substance)			ABCB1		C051890
CTD	decreases(response to substance)			ABCC1		C051890
CTD	decreases(expression)			ABCC1		C051890
CTD	affects(cotreatment)			ABCC1		C051890
CTD	decreases(expression)			ABCC1		C051890
CTD	affects(response to substance)			ABCC2		C051890
CTD	decreases(response to substance)			ABCC2		C051890
CTD	affects(export)			ABCC4		C051890
CTD	affects(response to substance)			ABCG2		C051890
CTD	affects(metabolic processing)			ABCG2		C051890
CTD	affects(response to substance)			ABCG2		C051890
CTD	increases(response to substance)			ABCG2		C051890
CTD	affects(export)			ABCG2		C051890
CTD	decreases(response to substance)			ABCG2		C051890
CTD	increases(response to substance)			ABCG2		C051890
CTD	increases(transport)			ABCG2		C051890
CTD	decreases(response to substance)			ABCG2		C051890
CTD	decreases(reaction)			ABCG2		C051890
CTD	decreases(expression)			ABHD13		C051890
CTD	decreases(expression)			ABI2		C051890
CTD	decreases(expression)			ACACA		C051890
CTD	increases(response to substance)			ACAT1		C051890
CTD	increases(expression)			ADAM19		C051890
CTD	decreases(expression)			ADD3		C051890
CTD	decreases(expression)			ADI1		C051890
CTD	decreases(expression)			AGT		C051890
CTD	increases(response to substance)			AK2		C051890
CTD	decreases(expression)			AKAP10		C051890
CTD	increases(expression)			ALAS2		C051890
CTD	decreases(expression)			ALB		C051890
CTD	decreases(expression)			ALDH1A1		C051890
CTD	increases(expression)			AMIGO2		C051890
CTD	affects(cotreatment)			ANGPTL2		C051890
CTD	increases(response to substance)			ANGPTL2		C051890
CTD	decreases(expression)			ANKRD17		C051890
CTD	decreases(expression)			ANKRD28		C051890
CTD	decreases(expression)			ANXA13		C051890
CTD	increases(expression)			ANXA2		C051890
CTD	increases(expression)			ANXA6		C051890
CTD	decreases(expression)			AP2B1		C051890
CTD	affects(cotreatment)			AP2S1		C051890
CTD	decreases(expression)			AP2S1		C051890
CTD	decreases(expression)			APC		C051890
CTD	increases(expression)			ARAF		C051890
CTD	decreases(reaction)			AREG		C051890
CTD	increases(expression)			AREG		C051890
CTD	affects(cotreatment)			ARF1		C051890
CTD	affects(response to substance)			ARF1		C051890
CTD	decreases(expression)			ARF1		C051890
CTD	decreases(expression)			ARHGAP5		C051890
CTD	increases(expression)			ARHGAP5		C051890
CTD	decreases(expression)			ARHGEF12		C051890
CTD	decreases(expression)			ARHGEF39		C051890
CTD	decreases(expression)			ARID2		C051890
CTD	decreases(expression)			ARID4A		C051890
CTD	increases(expression)			ARL4C		C051890
CTD	decreases(expression)			ARMC8		C051890
CTD	decreases(expression)			ARSB		C051890
CTD	affects(cotreatment)			ASS1		C051890
CTD	decreases(expression)			ASS1		C051890
CTD	increases(expression)			ATF3		C051890
CTD	decreases(expression)			ATG10		C051890
CTD	increases(expression)			ATL2		C051890
CTD	increases(phosphorylation)			ATM		C051890
CTD	decreases(response to substance)			ATP2B4		C051890
CTD	affects(cotreatment)			ATP5O		C051890
CTD	increases(response to substance)			ATP5O		C051890
CTD	decreases(expression)			ATP5S		C051890
CTD	affects(cotreatment)			ATP6		C051890
CTD	increases(expression)			ATP6		C051890
CTD	increases(response to substance)			ATP6V0B		C051890
CTD	decreases(response to substance)			ATP7A		C051890
CTD	increases(export)			ATP7A		C051890
CTD	decreases(expression)			ATRX		C051890
CTD	decreases(expression)			AURKB		C051890
CTD	increases(expression)			BAMBI		C051890
CTD	affects(cotreatment)			BAX		C051890
CTD	increases(expression)			BAX		C051890
CTD	affects(response to substance)			BCL2		C051890
CTD	affects(cotreatment)			BCL2		C051890
CTD	decreases(expression)			BCL2		C051890
CTD	affects(cotreatment)			BCL2		C051890
CTD	decreases(expression)			BCL2		C051890
CTD	decreases(expression)			BCL2L1		C051890
CTD	increases(reaction)			BCL2L1		C051890
CTD	decreases(expression)			BCL2L1		C051890
CTD	increases(expression)			BCL7A		C051890
CTD	increases(expression)			BCL9		C051890
CTD	decreases(expression)			BCR		C051890
CTD	affects(cotreatment)			BID		C051890
CTD	increases(cleavage)			BID		C051890
CTD	decreases(expression)			BID		C051890
CTD	affects(cotreatment)			BIRC5		C051890
CTD	decreases(expression)			BIRC5		C051890
CTD	decreases(expression)			BIRC5		C051890
CTD	decreases(expression)			BIRC5		C051890
CTD	increases(reaction)			BIRC5		C051890
CTD	increases(expression)			BMP8A		C051890
CTD	decreases(expression)			BOD1L1		C051890
CTD	affects(cotreatment)			BOLL		C051890
CTD	increases(response to substance)			BOLL		C051890
CTD	decreases(expression)			BTBD3		C051890
CTD	decreases(expression)			BUB1		C051890
CTD	increases(expression)			C11ORF80		C051890
CTD	decreases(expression)			C16ORF87		C051890
CTD	decreases(expression)			C1ORF43		C051890
CTD	decreases(expression)			C5ORF28		C051890
CTD	decreases(expression)			CABIN1		C051890
CTD	decreases(expression)			CACNA1I		C051890
CTD	affects(cotreatment)			CASP3		C051890
CTD	increases(activity)			CASP3		C051890
CTD	increases(activity)			CASP3		C051890
CTD	increases(cleavage)			CASP3		C051890
CTD	increases(reaction)			CASP3		C051890
CTD	increases(activity)			CASP3		C051890
CTD	decreases(reaction)			CASP3		C051890
CTD	increases(activity)			CASP3		C051890
CTD	increases(activity)			CASP3		C051890
CTD	increases(reaction)			CASP3		C051890
CTD	decreases(expression)			CASP4		C051890
CTD	increases(activity)			CASP8		C051890
CTD	increases(cleavage)			CASP8		C051890
CTD	increases(reaction)			CASP8		C051890
CTD	increases(activity)			CASP8		C051890
CTD	increases(reaction)			CASP8		C051890
CTD	decreases(reaction)			CASP9		C051890
CTD	increases(activity)			CASP9		C051890
CTD	increases(activity)			CASP9		C051890
CTD	increases(cleavage)			CASP9		C051890
CTD	increases(reaction)			CASP9		C051890
CTD	decreases(expression)			CCNA2		C051890
CTD	increases(response to substance)			CCNB1IP1		C051890
CTD	increases(response to substance)			CCNB2		C051890
CTD	decreases(expression)			CCNB2		C051890
CTD	decreases(expression)			CCNF		C051890
CTD	increases(expression)			CCNG2		C051890
CTD	increases(expression)			CCR1		C051890
CTD	decreases(expression)			CCR6		C051890
CTD	decreases(expression)			CCT6A		C051890
CTD	increases(expression)			CD47		C051890
CTD	increases(expression)			CD70		C051890
CTD	increases(expression)			CD80		C051890
CTD	increases(response to substance)			CDC20		C051890
CTD	decreases(expression)			CDC25B		C051890
CTD	decreases(expression)			CDC42BPA		C051890
CTD	decreases(expression)			CDH4		C051890
CTD	decreases(expression)			CDK1		C051890
CTD	decreases(expression)			CDK13		C051890
CTD	increases(expression)			CDK5R2		C051890
CTD	affects(expression)			CDK6		C051890
CTD	affects(cotreatment)			CDKN1A		C051890
CTD	increases(expression)			CDKN1A		C051890
CTD	affects(expression)			CDKN1A		C051890
CTD	increases(expression)			CDKN1A		C051890
CTD	increases(expression)			CDKN1A		C051890
CTD	increases(response to substance)			CDKN2A		C051890
CTD	affects(expression)			CDKN2A		C051890
CTD	decreases(expression)			CDKN2A		C051890
CTD	decreases(expression)			CDKN3		C051890
CTD	decreases(expression)			CDON		C051890
CTD	increases(response to substance)			CEL		C051890
CTD	decreases(expression)			CENPE		C051890
CTD	decreases(expression)			CENPE		C051890
CTD	decreases(expression)			CENPF		C051890
CTD	decreases(expression)			CEP192		C051890
CTD	decreases(expression)			CEP290		C051890
CTD	decreases(expression)			CEP295		C051890
CTD	increases(response to substance)			CES1		C051890
CTD	increases(hydrolysis)			CES1		C051890
CTD	increases(abundance)			CES2		C051890
CTD	increases(chemical synthesis)			CES2		C051890
CTD	increases(activity)			CES2		C051890
CTD	increases(metabolic processing)			CES2		C051890
CTD	affects(metabolic processing)			CES2		C051890
CTD	increases(activity)			CES2		C051890
CTD	affects(response to substance)			CES2		C051890
CTD	increases(chemical synthesis)			CES2		C051890
CTD	increases(activity)			CES2		C051890
CTD	increases(hydrolysis)			CES2		C051890
CTD	increases(hydrolysis)			CES2		C051890
CTD	increases(activity)			CES2		C051890
CTD	increases(metabolic processing)			CES2		C051890
CTD	increases(response to substance)			CES2		C051890
CTD	increases(expression)			CES2		C051890
CTD	increases(hydrolysis)			CES3		C051890
CTD	affects(response to substance)			CFLAR		C051890
CTD	decreases(reaction)			CFLAR		C051890
CTD	increases(activity)			CFLAR		C051890
CTD	decreases(expression)			CFLAR		C051890
CTD	decreases(expression)			CHD1		C051890
CTD	increases(phosphorylation)			CHEK1		C051890
CTD	decreases(reaction)			CHEK1		C051890
CTD	increases(phosphorylation)			CHEK1		C051890
CTD	increases(activity)			CHEK1		C051890
CTD	increases(phosphorylation)			CHEK1		C051890
CTD	increases(phosphorylation)			CHEK2		C051890
CTD	increases(expression)			CLGN		C051890
CTD	affects(cotreatment)			CLTC		C051890
CTD	affects(response to substance)			CLTC		C051890
CTD	decreases(expression)			CLTC		C051890
CTD	increases(expression)			CNNM2		C051890
CTD	decreases(expression)			COA1		C051890
CTD	increases(expression)			COL13A1		C051890
CTD	decreases(expression)			COL4A4		C051890
CTD	increases(expression)			COL6A1		C051890
CTD	decreases(response to substance)			COL7A1		C051890
CTD	increases(expression)			COMMD6		C051890
CTD	increases(expression)			COPA		C051890
CTD	decreases(expression)			COQ9		C051890
CTD	increases(expression)			CPE		C051890
CTD	decreases(expression)			CREBBP		C051890
CTD	decreases(expression)			CREBBP		C051890
CTD	decreases(expression)			CRIM1		C051890
CTD	decreases(expression)			CSH2		C051890
CTD	affects(cotreatment)			CTBP2		C051890
CTD	affects(response to substance)			CTBP2		C051890
CTD	affects(cotreatment)			CTBP2		C051890
CTD	decreases(expression)			CTBP2		C051890
CTD	decreases(expression)			CTBP2		C051890
CTD	increases(expression)			CTGF		C051890
CTD	increases(expression)			CTH		C051890
CTD	decreases(expression)			CUL4A		C051890
CTD	decreases(expression)			CXCL12		C051890
CTD	decreases(reaction)			CXCL8		C051890
CTD	increases(expression)			CXCL8		C051890
CTD	decreases(activity)			CYP2A6		C051890
CTD	decreases(activity)			CYP2C9		C051890
CTD	increases(response to substance)			CYP3A4		C051890
CTD	affects(metabolic processing)			CYP3A4		C051890
CTD	increases(oxidation)			CYP3A4		C051890
CTD	decreases(activity)			CYP3A4		C051890
CTD	affects(cotreatment)			CYP3A5		C051890
CTD	increases(expression)			CYP3A5		C051890
CTD	decreases(response to substance)			CYR61		C051890
CTD	decreases(expression)			DAGLB		C051890
CTD	increases(response to substance)			DBF4		C051890
CTD	decreases(expression)			DCAF8		C051890
CTD	decreases(expression)			DCLRE1A		C051890
CTD	increases(expression)			DCTN2		C051890
CTD	increases(expression)			DDB2		C051890
CTD	decreases(expression)			DDHD1		C051890
CTD	decreases(expression)			DDX17		C051890
CTD	decreases(expression)			DEDD		C051890
CTD	decreases(expression)			DEFA1		C051890
CTD	decreases(expression)			DENND4A		C051890
CTD	decreases(expression)			DENR		C051890
CTD	decreases(expression)			DEPDC1B		C051890
CTD	decreases(expression)			DESI2		C051890
CTD	increases(response to substance)			DFFB		C051890
CTD	decreases(expression)			DGCR8		C051890
CTD	decreases(expression)			DHFRL1		C051890
CTD	decreases(expression)			DIP2A		C051890
CTD	decreases(expression)			DLC1		C051890
CTD	affects(cotreatment)			DLG1		C051890
CTD	affects(response to substance)			DLG1		C051890
CTD	decreases(expression)			DLG1		C051890
CTD	increases(expression)			DLX4		C051890
CTD	increases(expression)			DMWD		C051890
CTD	decreases(expression)			DOK6		C051890
CTD	decreases(expression)			DPH2		C051890
CTD	decreases(expression)			DPH6		C051890
CTD	decreases(response to substance)			DPYD		C051890
CTD	decreases(expression)			DPYD		C051890
CTD	affects(cotreatment)			DRD5		C051890
CTD	increases(response to substance)			DRD5		C051890
CTD	affects(cotreatment)			DRG1		C051890
CTD	decreases(expression)			DRG1		C051890
CTD	decreases(expression)			DST		C051890
CTD	increases(expression)			DUSP2		C051890
CTD	decreases(expression)			DYRK1A		C051890
CTD	decreases(expression)			DYRK2		C051890
CTD	decreases(reaction)			EGFR		C051890
CTD	increases(phosphorylation)			EGFR		C051890
CTD	increases(activity)			EGFR		C051890
CTD	increases(expression)			EGR1		C051890
CTD	affects(expression)			EIF2AK4		C051890
CTD	affects(cotreatment)			EML2		C051890
CTD	increases(response to substance)			EML2		C051890
CTD	decreases(expression)			ENO1		C051890
CTD	decreases(expression)			EP300		C051890
CTD	increases(expression)			EPPK1		C051890
CTD	increases(expression)			ERBB4		C051890
CTD	decreases(expression)			ERC1		C051890
CTD	decreases(expression)			ERCC1		C051890
CTD	decreases(expression)			EREG		C051890
CTD	increases(expression)			ETS2		C051890
CTD	decreases(expression)			ETV6		C051890
CTD	decreases(expression)			EXOC4		C051890
CTD	affects(cotreatment)			F8		C051890
CTD	increases(response to substance)			F8		C051890
CTD	increases(expression)			FABP6		C051890
CTD	decreases(expression)			FAM219A		C051890
CTD	decreases(expression)			FAM3C		C051890
CTD	increases(expression)			FANCG		C051890
CTD	decreases(expression)			FARSB		C051890
CTD	increases(expression)			FAS		C051890
CTD	increases(localization)			FAS		C051890
CTD	increases(reaction)			FAS		C051890
CTD	affects(cotreatment)			FASLG		C051890
CTD	increases(expression)			FASLG		C051890
CTD	increases(expression)			FBXW5		C051890
CTD	affects(expression)			FCF1		C051890
CTD	increases(expression)			FGF2		C051890
CTD	decreases(expression)			FGF9		C051890
CTD	increases(expression)			FN1		C051890
CTD	increases(expression)			FN1		C051890
CTD	increases(expression)			FOS		C051890
CTD	decreases(expression)			FOS		C051890
CTD	increases(expression)			FOSB		C051890
CTD	decreases(expression)			FRMD5		C051890
CTD	decreases(expression)			FTO		C051890
CTD	increases(expression)			FXYD3		C051890
CTD	decreases(expression)			FYB		C051890
CTD	decreases(expression)			G2E3		C051890
CTD	decreases(expression)			GATA3		C051890
CTD	increases(expression)			GDF15		C051890
CTD	decreases(expression)			GGT1		C051890
CTD	affects(expression)			GJA1		C051890
CTD	decreases(expression)			GK		C051890
CTD	affects(expression)			GLRX3		C051890
CTD	increases(expression)			GNA13		C051890
CTD	affects(cotreatment)			GOLGA8A		C051890
CTD	increases(response to substance)			GOLGA8A		C051890
CTD	decreases(expression)			GPATCH2L		C051890
CTD	decreases(expression)			GPATCH4		C051890
CTD	increases(expression)			GPR183		C051890
CTD	increases(expression)			GPX3		C051890
CTD	increases(expression)			H2AFX		C051890
CTD	decreases(reaction)			HBEGF		C051890
CTD	increases(expression)			HBEGF		C051890
CTD	decreases(expression)			HBG1		C051890
CTD	increases(expression)			HCAR3		C051890
CTD	decreases(expression)			HCFC1		C051890
CTD	decreases(expression)			HECTD2		C051890
CTD	decreases(expression)			HELLS		C051890
CTD	increases(activity)			HES1		C051890
CTD	decreases(expression)			HIST1H2AC		C051890
CTD	decreases(expression)			HIST1H4C		C051890
CTD	decreases(expression)			HLA-B		C051890
CTD	increases(expression)			HLA-DRB1		C051890
CTD	increases(expression)			HLA-DRB4		C051890
CTD	decreases(expression)			HMMR		C051890
CTD	increases(expression)			HMX1		C051890
CTD	decreases(expression)			HN1		C051890
CTD	decreases(expression)			HNRNPA1		C051890
CTD	decreases(expression)			HNRNPD		C051890
CTD	decreases(expression)			HNRNPDL		C051890
CTD	increases(expression)			HRG		C051890
CTD	increases(expression)			HS3ST3B1		C051890
CTD	decreases(expression)			HSPA4L		C051890
CTD	affects(cotreatment)			HTATIP2		C051890
CTD	increases(expression)			HTATIP2		C051890
CTD	affects(expression)			HYPK		C051890
CTD	decreases(expression)			IBTK		C051890
CTD	decreases(expression)			ID2		C051890
CTD	increases(expression)			IER3		C051890
CTD	affects(cotreatment)			IFI27L2		C051890
CTD	increases(expression)			IFI27L2		C051890
CTD	increases(expression)			IFI6		C051890
CTD	increases(expression)			IFITM1		C051890
CTD	increases(expression)			IGF1		C051890
CTD	decreases(expression)			IGHG1		C051890
CTD	affects(cotreatment)			IL18		C051890
CTD	decreases(expression)			IL18		C051890
CTD	increases(expression)			IL1B		C051890
CTD	decreases(response to substance)			IL6		C051890
CTD	decreases(expression)			IMMP2L		C051890
CTD	affects(expression)			IMMT		C051890
CTD	decreases(expression)			ING3		C051890
CTD	decreases(expression)			INSIG1		C051890
CTD	increases(expression)			ITGA2		C051890
CTD	increases(response to substance)			ITGAE		C051890
CTD	decreases(expression)			ITGAV		C051890
CTD	increases(expression)			ITGAX		C051890
CTD	decreases(expression)			ITGB3BP		C051890
CTD	increases(expression)			JUN		C051890
CTD	affects(cotreatment)			KANSL1		C051890
CTD	affects(response to substance)			KANSL1		C051890
CTD	increases(expression)			KAT2B		C051890
CTD	decreases(expression)			KHDRBS1		C051890
CTD	increases(expression)			KIAA0040		C051890
CTD	affects(cotreatment)			KIAA0101		C051890
CTD	decreases(expression)			KIAA0101		C051890
CTD	decreases(expression)			KIF14		C051890
CTD	increases(expression)			KLF4		C051890
CTD	increases(expression)			KLF9		C051890
CTD	increases(expression)			KLHL24		C051890
CTD	affects(cotreatment)			KNG1		C051890
CTD	decreases(expression)			KNG1		C051890
CTD	decreases(expression)			KRIT1		C051890
CTD	affects(cotreatment)			KRT18		C051890
CTD	increases(cleavage)			KRT18		C051890
CTD	decreases(expression)			KRT5		C051890
CTD	decreases(expression)			LBH		C051890
CTD	affects(cotreatment)			LGALS8		C051890
CTD	increases(response to substance)			LGALS8		C051890
CTD	decreases(expression)			LINC00597		C051890
CTD	affects(cotreatment)			LMF1		C051890
CTD	increases(expression)			LMF1		C051890
CTD	decreases(expression)			LOXL3		C051890
CTD	decreases(expression)			LPCAT1		C051890
CTD	decreases(expression)			LRCH3		C051890
CTD	increases(response to substance)			LSM7		C051890
CTD	decreases(expression)			LTF		C051890
CTD	decreases(expression)			LTV1		C051890
CTD	decreases(expression)			MAD2L1		C051890
CTD	increases(expression)			MAL		C051890
CTD	decreases(expression)			MALAT1		C051890
CTD	affects(cotreatment)			MALAT1		C051890
CTD	affects(response to substance)			MALAT1		C051890
CTD	increases(expression)			MALL		C051890
CTD	decreases(expression)			MAP3K5		C051890
CTD	decreases(expression)			MAP4K3		C051890
CTD	increases(activity)			MAPK1		C051890
CTD	increases(phosphorylation)			MAPK1		C051890
CTD	increases(activity)			MAPK3		C051890
CTD	increases(phosphorylation)			MAPK3		C051890
CTD	increases(expression)			MARCH6		C051890
CTD	increases(expression)			MATN2		C051890
CTD	decreases(expression)			MATR3		C051890
CTD	decreases(expression)			MBNL1		C051890
CTD	decreases(expression)			MBP		C051890
CTD	decreases(expression)			MCCC2		C051890
CTD	affects(cotreatment)			MCCC2		C051890
CTD	affects(response to substance)			MCCC2		C051890
CTD	decreases(expression)			MCF2L		C051890
CTD	decreases(response to substance)			MCL1		C051890
CTD	decreases(expression)			MCM4		C051890
CTD	increases(expression)			MDM2		C051890
CTD	affects(expression)			MDN1		C051890
CTD	decreases(expression)			MED13		C051890
CTD	increases(expression)			MEF2B		C051890
CTD	decreases(expression)			MGMT		C051890
CTD	increases(response to substance)			MGMT		C051890
CTD	decreases(expression)			MIP		C051890
CTD	increases(expression)			MIR128-1		C051890
CTD	decreases(expression)			MIR17HG		C051890
CTD	increases(expression)			MIR34A		C051890
CTD	increases(expression)			MIR449A		C051890
CTD	decreases(expression)			MKX		C051890
CTD	affects(response to substance)			MLH1		C051890
CTD	increases(expression)			MMP9		C051890
CTD	decreases(expression)			MPO		C051890
CTD	increases(expression)			MPP7		C051890
CTD	decreases(expression)			MPST		C051890
CTD	decreases(expression)			MRPS30		C051890
CTD	decreases(expression)			MSH2		C051890
CTD	affects(response to substance)			MSH2		C051890
CTD	decreases(expression)			MTHFD1L		C051890
CTD	decreases(expression)			MTHFS		C051890
CTD	decreases(expression)			MX2		C051890
CTD	increases(response to substance)			MYB		C051890
CTD	decreases(expression)			MYH10		C051890
CTD	decreases(expression)			MYSM1		C051890
CTD	decreases(expression)			N4BP1		C051890
CTD	decreases(expression)			NBPF1		C051890
CTD	decreases(expression)			NCK1		C051890
CTD	increases(expression)			NCOA1		C051890
CTD	decreases(expression)			NCOR1		C051890
CTD	affects(cotreatment)			NCOR1		C051890
CTD	affects(response to substance)			NCOR1		C051890
CTD	affects(response to substance)			NCSTN		C051890
CTD	decreases(response to substance)			NDRG1		C051890
CTD	decreases(expression)			NEK2		C051890
CTD	increases(activity)			NFKB1		C051890
CTD	decreases(expression)			NFKBIA		C051890
CTD	decreases(reaction)			NFKBIA		C051890
CTD	increases(phosphorylation)			NFKBIA		C051890
CTD	increases(response to substance)			NFKBIA		C051890
CTD	increases(expression)			NID1		C051890
CTD	decreases(expression)			NQO1		C051890
CTD	decreases(response to substance)			NR3C1		C051890
CTD	affects(cotreatment)			NRIP1		C051890
CTD	increases(expression)			NRIP1		C051890
CTD	decreases(expression)			NSF		C051890
CTD	decreases(expression)			NSMAF		C051890
CTD	decreases(expression)			NUP153		C051890
CTD	decreases(expression)			NUSAP1		C051890
CTD	increases(expression)			OPHN1		C051890
CTD	increases(response to substance)			ORC1		C051890
CTD	increases(expression)			OSMR		C051890
CTD	decreases(response to substance)			OSMR		C051890
CTD	increases(expression)			PAG1		C051890
CTD	decreases(expression)			PAM		C051890
CTD	decreases(expression)			PAN3		C051890
CTD	decreases(expression)			PAWR		C051890
CTD	decreases(expression)			PAX5		C051890
CTD	decreases(expression)			PAX7		C051890
CTD	decreases(response to substance)			PBXIP1		C051890
CTD	decreases(expression)			PCBD2		C051890
CTD	increases(expression)			PCDHGC3		C051890
CTD	decreases(expression)			PDE4B		C051890
CTD	decreases(expression)			PDLIM5		C051890
CTD	increases(expression)			PGM2L1		C051890
CTD	decreases(expression)			PHLDA1		C051890
CTD	increases(expression)			PHLDA2		C051890
CTD	decreases(expression)			PI4KAP2		C051890
CTD	decreases(expression)			PIGW		C051890
CTD	decreases(expression)			PKDCC		C051890
CTD	decreases(expression)			PLAT		C051890
CTD	increases(expression)			PLCXD2		C051890
CTD	decreases(expression)			PLEKHA5		C051890
CTD	increases(expression)			PLEKHH3		C051890
CTD	decreases(expression)			PLK1		C051890
CTD	increases(expression)			PLK2		C051890
CTD	increases(expression)			PLK3		C051890
CTD	affects(cotreatment)			PLRG1		C051890
CTD	increases(expression)			PLRG1		C051890
CTD	increases(expression)			PMAIP1		C051890
CTD	increases(expression)			PNRC1		C051890
CTD	decreases(expression)			POGZ		C051890
CTD	increases(response to substance)			POLA1		C051890
CTD	increases(response to substance)			POLE2		C051890
CTD	decreases(expression)			POLK		C051890
CTD	increases(response to substance)			POLR3G		C051890
CTD	increases(response to substance)			POR		C051890
CTD	decreases(response to substance)			PPAP2A		C051890
CTD	increases(expression)			PPM1D		C051890
CTD	affects(cotreatment)			PPP3CA		C051890
CTD	increases(expression)			PPP3CA		C051890
CTD	decreases(expression)			PPP3CA		C051890
CTD	affects(cotreatment)			PPP3CA		C051890
CTD	affects(response to substance)			PPP3CA		C051890
CTD	decreases(expression)			PPP3CB		C051890
CTD	decreases(expression)			PRKAA1		C051890
CTD	increases(phosphorylation)			PRKCA		C051890
CTD	increases(phosphorylation)			PRKCB		C051890
CTD	increases(phosphorylation)			PRKCD		C051890
CTD	increases(phosphorylation)			PRKCI		C051890
CTD	decreases(reaction)			PRKDC		C051890
CTD	increases(phosphorylation)			PRKDC		C051890
CTD	increases(phosphorylation)			PRKDC		C051890
CTD	decreases(expression)			PROM1		C051890
CTD	affects(cotreatment)			PRR13		C051890
CTD	increases(expression)			PRR13		C051890
CTD	increases(response to substance)			PSAT1		C051890
CTD	affects(cotreatment)			PSG9		C051890
CTD	increases(response to substance)			PSG9		C051890
CTD	affects(cotreatment)			PTCH1		C051890
CTD	increases(expression)			PTCH1		C051890
CTD	increases(expression)			PTGES		C051890
CTD	decreases(expression)			PTK2		C051890
CTD	decreases(expression)			PTP4A1		C051890
CTD	decreases(expression)			PTPN13		C051890
CTD	increases(expression)			PTPN22		C051890
CTD	increases(expression)			PTPRD		C051890
CTD	decreases(expression)			PTPRG		C051890
CTD	increases(expression)			PTPRN		C051890
CTD	decreases(response to substance)			RAB31		C051890
CTD	increases(expression)			RAC3		C051890
CTD	decreases(expression)			RAD23B		C051890
CTD	affects(cotreatment)			RAD51		C051890
CTD	increases(expression)			RAD51		C051890
CTD	decreases(expression)			RASA1		C051890
CTD	affects(expression)			RB1		C051890
CTD	decreases(expression)			RBBP5		C051890
CTD	increases(expression)			RBBP5		C051890
CTD	decreases(expression)			RBL1		C051890
CTD	increases(expression)			RBM24		C051890
CTD	decreases(response to substance)			RBMS1		C051890
CTD	affects(cotreatment)			RBPJ		C051890
CTD	decreases(expression)			RBPJ		C051890
CTD	decreases(expression)			RBPJ		C051890
CTD	increases(expression)			RECK		C051890
CTD	affects(cotreatment)			RELA		C051890
CTD	increases(expression)			RELA		C051890
CTD	increases(activity)			RELA		C051890
CTD	decreases(response to substance)			RELA		C051890
CTD	decreases(expression)			REPS1		C051890
CTD	affects(cotreatment)			REPS1		C051890
CTD	affects(response to substance)			REPS1		C051890
CTD	decreases(expression)			RFC3		C051890
CTD	increases(response to substance)			RFC3		C051890
CTD	increases(expression)			RGS1		C051890
CTD	decreases(expression)			RGS22		C051890
CTD	increases(expression)			RHOB		C051890
CTD	increases(expression)			RHOU		C051890
CTD	decreases(expression)			RLIM		C051890
CTD	decreases(reaction)			RNF34		C051890
CTD	increases(activity)			RNF34		C051890
CTD	decreases(response to substance)			RNF34		C051890
CTD	decreases(expression)			RPL4		C051890
CTD	decreases(expression)			RUNX1		C051890
CTD	increases(expression)			SAMD9		C051890
CTD	affects(expression)			SAMHD1		C051890
CTD	increases(expression)			SAT1		C051890
CTD	decreases(response to substance)			SAT1		C051890
CTD	decreases(expression)			SCAF4		C051890
CTD	decreases(expression)			SCAI		C051890
CTD	affects(cotreatment)			SCAMP3		C051890
CTD	decreases(expression)			SCAMP3		C051890
CTD	increases(expression)			SCD5		C051890
CTD	increases(expression)			SDC4		C051890
CTD	decreases(expression)			SEC31A		C051890
CTD	increases(expression)			SEMA3C		C051890
CTD	decreases(expression)			SENP6		C051890
CTD	affects(cotreatment)			SERPINB5		C051890
CTD	decreases(expression)			SERPINB5		C051890
CTD	affects(cotreatment)			SERPINE2		C051890
CTD	increases(response to substance)			SERPINE2		C051890
CTD	increases(expression)			SERTAD1		C051890
CTD	increases(expression)			SESN2		C051890
CTD	decreases(expression)			SETD1B		C051890
CTD	decreases(expression)			SETD5		C051890
CTD	affects(cotreatment)			SFN		C051890
CTD	decreases(expression)			SFN		C051890
CTD	increases(expression)			SGK1		C051890
CTD	increases(expression)			SGK1		C051890
CTD	increases(expression)			SGK1		C051890
CTD	decreases(expression)			SGOL2		C051890
CTD	affects(cotreatment)			SIGLEC1		C051890
CTD	increases(expression)			SIGLEC1		C051890
CTD	increases(response to substance)			SKP2		C051890
CTD	decreases(expression)			SLC16A4		C051890
CTD	decreases(expression)			SLC19A1		C051890
CTD	decreases(expression)			SLC25A21		C051890
CTD	decreases(expression)			SLC30A1		C051890
CTD	increases(expression)			SLC9A3R2		C051890
CTD	decreases(expression)			SMAD3		C051890
CTD	decreases(expression)			SMCHD1		C051890
CTD	decreases(expression)			SMEK2		C051890
CTD	decreases(expression)			SMU1		C051890
CTD	affects(expression)			SMURF1		C051890
CTD	decreases(expression)			SNRPA1		C051890
CTD	affects(cotreatment)			SNRPA1		C051890
CTD	affects(response to substance)			SNRPA1		C051890
CTD	increases(response to substance)			SNRPF		C051890
CTD	decreases(expression)			SNX18		C051890
CTD	affects(cotreatment)			SOD2		C051890
CTD	increases(activity)			SOD2		C051890
CTD	decreases(expression)			SP1		C051890
CTD	increases(phosphorylation)			SP1		C051890
CTD	affects(cotreatment)			SP1		C051890
CTD	affects(response to substance)			SP1		C051890
CTD	increases(expression)			SPIB		C051890
CTD	affects(cotreatment)			SRP19		C051890
CTD	decreases(expression)			SRP19		C051890
CTD	increases(phosphorylation)			STAT1		C051890
CTD	increases(localization)			STAT1		C051890
CTD	increases(reaction)			STAT1		C051890
CTD	decreases(reaction)			STAT1		C051890
CTD	increases(expression)			STK38		C051890
CTD	decreases(expression)			STK4		C051890
CTD	decreases(expression)			STK4		C051890
CTD	affects(cotreatment)			STK4		C051890
CTD	affects(response to substance)			STK4		C051890
CTD	affects(cotreatment)			STX5		C051890
CTD	increases(expression)			STX5		C051890
CTD	increases(expression)			SULT1A4		C051890
CTD	increases(expression)			SYDE2		C051890
CTD	decreases(expression)			SYT1		C051890
CTD	decreases(expression)			TAF2		C051890
CTD	affects(cotreatment)			TAF5L		C051890
CTD	decreases(expression)			TAF5L		C051890
CTD	increases(expression)			TBCC		C051890
CTD	increases(expression)			TBCC		C051890
CTD	decreases(expression)			TCF12		C051890
CTD	decreases(expression)			TCF7L2		C051890
CTD	decreases(expression)			TFCP2		C051890
CTD	decreases(expression)			TFPI		C051890
CTD	increases(expression)			TFRC		C051890
CTD	decreases(reaction)			TGFA		C051890
CTD	increases(secretion)			TGFA		C051890
CTD	decreases(response to substance)			TGFA		C051890
CTD	decreases(expression)			TGFBI		C051890
CTD	decreases(response to substance)			THBS1		C051890
CTD	decreases(expression)			THEM4		C051890
CTD	decreases(expression)			THNSL1		C051890
CTD	decreases(expression)			THRAP3		C051890
CTD	increases(expression)			THY1		C051890
CTD	decreases(expression)			TMEM123		C051890
CTD	decreases(expression)			TMEM41B		C051890
CTD	increases(expression)			TNF		C051890
CTD	decreases(expression)			TNFAIP6		C051890
CTD	decreases(reaction)			TNFSF10		C051890
CTD	increases(activity)			TNFSF10		C051890
CTD	increases(expression)			TOB1		C051890
CTD	increases(expression)			TOB2		C051890
CTD	affects(binding)			TOP1		C051890
CTD	decreases(activity)			TOP1		C051890
CTD	affects(response to substance)			TOP1		C051890
CTD	decreases(expression)			TOP2A		C051890
CTD	increases(response to substance)			TOP2A		C051890
CTD	decreases(expression)			TOPORS		C051890
CTD	affects(cotreatment)			TP53		C051890
CTD	increases(ubiquitination)			TP53		C051890
CTD	increases(expression)			TP53		C051890
CTD	increases(expression)			TP53		C051890
CTD	increases(activity)			TP53		C051890
CTD	increases(phosphorylation)			TP53		C051890
CTD	increases(phosphorylation)			TP53		C051890
CTD	increases(phosphorylation)			TP53		C051890
CTD	affects(response to substance)			TP53		C051890
CTD	affects(response to substance)			TP53		C051890
CTD	decreases(reaction)			TP53		C051890
CTD	increases(phosphorylation)			TP53		C051890
CTD	increases(response to substance)			TP53		C051890
CTD	increases(expression)			TP53INP1		C051890
CTD	increases(expression)			TPMT		C051890
CTD	affects(cotreatment)			TPMT		C051890
CTD	affects(response to substance)			TPMT		C051890
CTD	increases(expression)			TPPP		C051890
CTD	decreases(expression)			TPX2		C051890
CTD	increases(expression)			TRADD		C051890
CTD	decreases(expression)			TRAF1		C051890
CTD	increases(expression)			TRAF1		C051890
CTD	decreases(expression)			TRDMT1		C051890
CTD	increases(expression)			TRIB1		C051890
CTD	affects(expression)			TRIB2		C051890
CTD	increases(expression)			TRIM4		C051890
CTD	increases(expression)			TRIM9		C051890
CTD	decreases(expression)			TRMT13		C051890
CTD	decreases(expression)			TSEN2		C051890
CTD	affects(cotreatment)			TSPAN8		C051890
CTD	decreases(expression)			TSPAN8		C051890
CTD	decreases(expression)			TTK		C051890
CTD	increases(expression)			TXNIP		C051890
CTD	affects(cotreatment)			TYMP		C051890
CTD	affects(response to substance)			TYMP		C051890
CTD	affects(cotreatment)			TYMS		C051890
CTD	affects(response to substance)			TYMS		C051890
CTD	decreases(expression)			UBE2C		C051890
CTD	decreases(expression)			UBE2E3		C051890
CTD	decreases(expression)			UBE2J2		C051890
CTD	decreases(expression)			UCHL5		C051890
CTD	decreases(expression)			UGGT2		C051890
CTD	affects(response to substance)			UGT1A		C051890
CTD	increases(response to substance)			UGT1A		C051890
CTD	decreases(glucuronidation)			UGT1A1		C051890
CTD	affects(cotreatment)			UGT1A1		C051890
CTD	affects(response to substance)			UGT1A1		C051890
CTD	affects(response to substance)			UGT1A1		C051890
CTD	affects(response to substance)			UGT1A1		C051890
CTD	affects(metabolic processing)			UGT1A1		C051890
CTD	affects(response to substance)			UGT1A1		C051890
CTD	decreases(glucuronidation)			UGT1A1		C051890
CTD	decreases(activity)			UGT1A1		C051890
CTD	increases(glucuronidation)			UGT1A1		C051890
CTD	increases(glucuronidation)			UGT1A1		C051890
CTD	increases(metabolic processing)			UGT1A1		C051890
CTD	affects(response to substance)			UGT1A10		C051890
CTD	decreases(activity)			UGT1A10		C051890
CTD	increases(glucuronidation)			UGT1A10		C051890
CTD	increases(glucuronidation)			UGT1A6		C051890
CTD	increases(glucuronidation)			UGT1A7		C051890
CTD	increases(glucuronidation)			UGT1A8		C051890
CTD	increases(glucuronidation)			UGT1A9		C051890
CTD	increases(expression)			ULBP2		C051890
CTD	decreases(expression)			ULK4		C051890
CTD	decreases(expression)			USO1		C051890
CTD	decreases(expression)			USP24		C051890
CTD	affects(cotreatment)			UTP3		C051890
CTD	increases(expression)			UTP3		C051890
CTD	decreases(expression)			VPS4A		C051890
CTD	decreases(expression)			VTI1A		C051890
CTD	decreases(expression)			WAPAL		C051890
CTD	decreases(expression)			WASL		C051890
CTD	increases(expression)			WNT16		C051890
CTD	increases(expression)			WSB1		C051890
CTD	affects(cotreatment)			XIAP		C051890
CTD	increases(cleavage)			XIAP		C051890
CTD	decreases(expression)			XPA		C051890
CTD	decreases(expression)			XPO7		C051890
CTD	decreases(expression)			XRCC4		C051890
CTD	decreases(expression)			XRCC5		C051890
CTD	decreases(expression)			YAF2		C051890
CTD	decreases(expression)			YES1		C051890
CTD	decreases(expression)			ZBTB14		C051890
CTD	decreases(expression)			ZBTB20		C051890
CTD	decreases(expression)			ZC3HAV1		C051890
CTD	increases(expression)			ZCCHC12		C051890
CTD	decreases(expression)			ZDHHC21		C051890
CTD	decreases(expression)			ZFP36L2		C051890
CTD	decreases(expression)			ZFX		C051890
CTD	decreases(expression)			ZNF207		C051890
CTD	affects(cotreatment)			ZNF32		C051890
CTD	increases(response to substance)			ZNF32		C051890
CTD	affects(cotreatment)			ZNF408		C051890
CTD	increases(expression)			ZNF408		C051890
CTD	decreases(expression)			ZNF574		C051890
CTD	affects(cotreatment)			ZNF582		C051890
CTD	increases(response to substance)			ZNF582		C051890
CTD	decreases(expression)			ZNF668		C051890
CTD	decreases(expression)			ZNRF1		C051890
CTD	affects(cotreatment)			ZRSR2		C051890
CTD	increases(response to substance)			ZRSR2		C051890
CTD	decreases(expression)			ZSCAN31		C051890
PubChem	Potency-Replicate_1	uM	3.378	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	3.647	AR	-	GI(Protien) :
PubChem	AR Potency (uM)	uM	8.742	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	11.883	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	19.570	ESR1	-	GI(Protien) :
PubChem	Potency	uM	2.372	TDP1	-	GI(Protien) :
PubChem	Potency	uM	2.372	TDP1	-	GI(Protien) :
ChEMBL	Potency	nM	25118.900	HSD17B10	-	Target : CHEMBL4159

Download gene sets

gmt, text, Detailed text