Tan Lab | DSigDB

Gene Set: D4 : CTD - nefazodone

Collection

D4 : CTD

Chemical Name

nefazodone ( From PubChem : NEFAZODONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
470.007 g/mol	0	7	3.5548	True

Structure

InChI

InChI=1S/C25H32ClN5O2/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22/h3-6,8-11,20H,2,7,12-19H2,1H3

InChIKey

VRBKIVRKKCLPHA-UHFFFAOYSA-N

Links

Gene (16 / 31)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			ABCB11		C051752
CTD	increases(transport)			ABCB11		C051752
CTD	decreases(activity)			ABCB11		C051752
CTD	increases(activity)			CASP3		C051752
CTD	increases(reaction)			CASP3		C051752
CTD	increases(activity)			CASP7		C051752
CTD	increases(reaction)			CASP7		C051752
CTD	increases(response to substance)			CYP3A4		C051752
CTD	decreases(reaction)			CYP3A4		C051752
CTD	increases(activity)			CYP3A4		C051752
CTD	increases(oxidation)			CYP3A4		C051752
CTD	decreases(reaction)			CYP3A5		C051752
CTD	increases(activity)			CYP3A5		C051752
CTD	increases(oxidation)			CYP3A5		C051752
CTD	affects(binding)			HTR1A		C051752
CTD	affects(binding)			HTR2C		C051752
CTD	affects(cotreatment)			IFNG		C051752
CTD	increases(response to substance)			IFNG		C051752
CTD	affects(cotreatment)			IL1A		C051752
CTD	increases(response to substance)			IL1A		C051752
CTD	affects(binding)			KCNH2		C051752
CTD	decreases(activity)			KCNH2		C051752
CTD	decreases(activity)			KCNH2		C051752
CTD	decreases(reaction)			SLC22A2		C051752
CTD	increases(uptake)			SLC22A2		C051752
CTD	affects(cotreatment)			TNF		C051752
CTD	increases(response to substance)			TNF		C051752
PubChem	None	uM		ADRBK1	-	GI(Protien) :
PubChem	None	uM		DRD2	-	GI(Protien) :
PubChem	None	uM		DRD3	-	GI(Protien) :
PubChem	Potency	uM	11.582	TDP1	-	GI(Protien) :

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