Tan Lab | DSigDB

Gene Set: D4 : CTD - 1,2-dithiol-3-thione

Collection

D4 : CTD

Chemical Name

1,2-dithiol-3-thione ( From PubChem : 3H-1,2-DITHIOLE-3-THIONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
134.243 g/mol	0	3	2.5391	True

Structure

InChI

InChI=1S/C3H2S3/c4-3-1-2-5-6-3/h1-2H

InChIKey

LZENMJMJWQSSNJ-UHFFFAOYSA-N

Links

Gene (10 / 16)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			GCLC		C049325
CTD	increases(activity)			GSR		C049325
CTD	increases(expression)			GSR		C049325
CTD	decreases(expression)			IVL		C049325
CTD	increases(activity)			NQO1		C049325
CTD	increases(expression)			NQO1		C049325
PubChem	Potency	uM	2.239	ALDH1A1	-	GI(Protien) :
PubChem	Potency	uM	7.943	ALOX15	-	GI(Protien) :
PubChem	Potency	uM	6.310	HPGD	-	GI(Protien) :
PubChem	Potency	uM	25.119	KAT2A	-	GI(Protien) :
PubChem	Potency	uM	19.953	VDR	-	GI(Protien) :
ChEMBL	Potency	nM	2238.700	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	7943.300	ALOX15	-	Target : CHEMBL2903
ChEMBL	Potency	nM	6309.600	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	25118.900	KAT2A	-	Target : CHEMBL5501
ChEMBL	Inhibition	-		PTPN1	-	Target : CHEMBL335

Download gene sets

gmt, text, Detailed text

Contact us
Tan Lab , Mail Stop 8117
12801 East 17th Avenue
Division of Medical Oncology , Department of Medicine
University of Colorado School of Medicine
Aurora, CO 80045, USA

* Best viewed in the latest version of Chrome (42+), Safari (8+), IE (11+) or Firefox (35+).