Tan Lab | DSigDB

Gene Set: D4 : CTD - felbamate

Collection

D4 : CTD

Chemical Name

felbamate ( From PubChem : FELBAMATE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
238.24 g/mol	2	6	2.3614	True

Structure

InChI

InChI=1S/C11H14N2O4/c12-10(14)16-6-9(7-17-11(13)15)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H2,12,14)(H2,13,15)

InChIKey

Links

Gene (14 / 33)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(reaction)			CYP3A4		C047360
CTD	increases(chemical synthesis)			CYP3A4		C047360
CTD	increases(metabolic processing)			CYP3A4		C047360
CTD	affects(binding)			GABRA1		C047360
CTD	decreases(activity)			GABRA1		C047360
CTD	increases(activity)			GABRA1		C047360
CTD	affects(binding)			GABRA2		C047360
CTD	increases(activity)			GABRA2		C047360
CTD	affects(binding)			GABRA4		C047360
CTD	decreases(activity)			GABRA4		C047360
CTD	affects(binding)			GABRA6		C047360
CTD	decreases(activity)			GABRA6		C047360
CTD	affects(binding)			GABRB1		C047360
CTD	decreases(activity)			GABRB1		C047360
CTD	affects(binding)			GABRB2		C047360
CTD	increases(activity)			GABRB2		C047360
CTD	affects(binding)			GABRB3		C047360
CTD	decreases(activity)			GABRB3		C047360
CTD	increases(activity)			GABRB3		C047360
CTD	affects(binding)			GABRG2		C047360
CTD	decreases(activity)			GABRG2		C047360
CTD	increases(activity)			GABRG2		C047360
PubChem	Potency	uM	0.794	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
PubChem	None	uM		DRD1	-	GI(Protien) :
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	AC50	nM	794.330	CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	794.300	CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340

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