Tan Lab | DSigDB

Gene Set: D4 : CTD - ropinirole

Collection

D4 : CTD

Chemical Name

ropinirole ( From PubChem : ROPINIROLE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
260.375 g/mol	1	3	2.9837	True

Structure

InChI

InChI=1S/C16H24N2O/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15/h5-7H,3-4,8-12H2,1-2H3,(H,17,19)

InChIKey

Links

Gene (10 / 21)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			BCL2		C046649
CTD	decreases(reaction)			CASP3		C046649
CTD	increases(cleavage)			CASP3		C046649
CTD	decreases(reaction)			CASP9		C046649
CTD	increases(cleavage)			CASP9		C046649
CTD	affects(binding)			DRD2		C046649
CTD	increases(activity)			DRD2		C046649
CTD	affects(binding)			DRD3		C046649
CTD	increases(activity)			DRD3		C046649
CTD	affects(binding)			DRD4		C046649
CTD	increases(activity)			DRD4		C046649
CTD	decreases(reaction)			JUN		C046649
CTD	increases(phosphorylation)			JUN		C046649
CTD	increases(phosphorylation)			MAPK1		C046649
CTD	increases(phosphorylation)			MAPK3		C046649
PubChem	Potency	uM	3.162	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
PubChem	None	uM		DRD3	-	GI(Protien) :
PubChem	None	uM		DRD3	-	GI(Protien) :
ChEMBL	Potency	nM	3162.300	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	3162.280	CYP2D6	-	Target : CHEMBL289

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