Tan Lab | DSigDB

Gene Set: D4 : CTD - tryptanthrine

Collection

D4 : CTD

Chemical Name

tryptanthrine ( From PubChem : TRYPTANTHRIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
248.236 g/mol	0	4	1.9301	True

Structure

InChI

InChI=1S/C15H8N2O2/c18-13-10-6-2-4-8-12(10)17-14(13)16-11-7-3-1-5-9(11)15(17)19/h1-8H

InChIKey

Links

Gene (26 / 35)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(binding)			ABCB1		C046243
CTD	decreases(expression)			ABCB1		C046243
CTD	increases(expression)			CALCA		C046243
CTD	decreases(expression)			CCND1		C046243
CTD	decreases(expression)			CCND3		C046243
CTD	decreases(expression)			CDK4		C046243
CTD	decreases(expression)			CDK6		C046243
CTD	increases(expression)			GAP43		C046243
CTD	increases(expression)			MAP2		C046243
CTD	increases(expression)			MAPT		C046243
CTD	decreases(expression)			MYCN		C046243
CTD	increases(expression)			NEFH		C046243
CTD	increases(expression)			SST		C046243
CTD	decreases(expression)			TP53		C046243
CTD	increases(degradation)			TP53		C046243
PubChem	None	uM		AHR	-	GI(Protien) :
PubChem	None	uM		AHR	-	GI(Protien) :
PubChem	Potency	uM	1.158	GMNN	-	GI(Protien) :
PubChem	None	uM		HCRTR1	-	GI(Protien) :
PubChem	Potency	uM	11.220	HTT	-	GI(Protien) :
PubChem	IC50	uM		MPI	-	GI(Protien) :
PubChem	Potency	uM	5.173	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	6.513	NFE2L2	-	GI(Protien) :
PubChem	None	uM		NR1I2	-	GI(Protien) :
PubChem	None	uM		NR5A1	-	GI(Protien) :
PubChem	None	uM		NR5A2	-	GI(Protien) :
PubChem	None	uM		PAFAH2	-	GI(Protien) :
PubChem	None	uM		PTGER2	-	GI(Protien) :
PubChem	Potency	uM	0.461	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.517	TDP1	-	GI(Protien) :
PubChem	Potency	uM	1.300	TDP1	-	GI(Protien) :
PubChem	Potency	uM	1.300	TDP1	-	GI(Protien) :
ChEMBL	Potency	nM	11220.200	HTT	-	Target : CHEMBL5514
ChEMBL	Potency	nM	5173.500	NFE2L2	-	Target : CHEMBL1075094
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781

Download gene sets