Tan Lab | DSigDB

Gene Set: D4 : CTD - flavone

Collection

D4 : CTD

Chemical Name

flavone ( From PubChem : FLAVONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
222.239 g/mol	0	2	3.46	True

Structure

InChI

InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H

InChIKey

VHBFFQKBGNRLFZ-UHFFFAOYSA-N

Links

Gene (23 / 57)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(export)			ABCC1		C043562
CTD	decreases(reaction)			ABCC1		C043562
CTD	decreases(activity)			ABCC1		C043562
CTD	increases(expression)			ABCG2		C043562
CTD	affects(binding)			AHR		C043562
CTD	increases(activity)			CASP3		C043562
CTD	increases(reaction)			CASP3		C043562
CTD	increases(activity)			CYP19A1		C043562
CTD	decreases(reaction)			CYP1A1		C043562
CTD	increases(expression)			CYP1A1		C043562
CTD	decreases(activity)			CYP1A1		C043562
CTD	increases(expression)			CYP1A1		C043562
CTD	decreases(reaction)			CYP1A2		C043562
CTD	increases(expression)			CYP1A2		C043562
CTD	decreases(activity)			CYP1A2		C043562
CTD	affects(binding)			CYP1B1		C043562
CTD	decreases(activity)			CYP1B1		C043562
CTD	increases(expression)			CYP1B1		C043562
CTD	decreases(reaction)			CYP2C9		C043562
CTD	increases(hydroxylation)			CYP2C9		C043562
CTD	affects(binding)			CYP3A4		C043562
CTD	decreases(activity)			CYP3A4		C043562
CTD	decreases(reaction)			CYP3A4		C043562
CTD	increases(chemical synthesis)			CYP3A4		C043562
CTD	increases(oxidation)			CYP3A4		C043562
CTD	increases(reaction)			CYP3A4		C043562
CTD	affects(binding)			ESR2		C043562
CTD	affects(binding)			ESRRA		C043562
CTD	increases(activity)			ESRRA		C043562
CTD	affects(binding)			ESRRB		C043562
CTD	increases(activity)			ESRRB		C043562
CTD	increases(expression)			PON1		C043562
PubChem	Potency-Replicate_1	uM	3.834	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	7.406	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	8.251	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	24.337	AHR	-	GI(Protien) :
PubChem	Potency	uM	44.668	AHR	-	GI(Protien) :
PubChem	Potency	uM	50.119	AHR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	40.611	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	50.907	AR	-	GI(Protien) :
PubChem	Potency	uM	20.588	ATAD5	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	2.434	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	6.859	ESR1	-	GI(Protien) :
PubChem	Potency	uM	8.912	HPGD	-	GI(Protien) :
PubChem	Potency	uM	4.609	NFE2L2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	5.448	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	5.448	NFE2L2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	5.497	NFE2L2	-	GI(Protien) :
PubChem	None	uM		NR0B1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	22.387	NR1I2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	44.668	NR1I2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	15.485	NR3C1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	27.549	NR3C1	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
PubChem	None	uM		SENP8	-	GI(Protien) :
ChEMBL	Potency	nM	20587.800	ATAD5	-	Target : CHEMBL1741209
ChEMBL	Potency	nM	8912.500	HPGD	-	Target : CHEMBL1293255

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