Tan Lab | DSigDB

Gene Set: D4 : CTD - chrysin

Collection

D4 : CTD

Chemical Name

chrysin ( From PubChem : CHRYSIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
254.238 g/mol	2	4	2.8712	True

Structure

InChI

InChI=1S/C15H10O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-8,16-17H

InChIKey

RTIXKCRFFJGDFG-UHFFFAOYSA-N

Links

Gene (90 / 252)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(activity)			ABCB1		C043561
CTD	decreases(activity)			ABCB1		C043561
CTD	decreases(export)			ABCB1		C043561
CTD	increases(expression)			ABCB1		C043561
CTD	affects(reaction)			ABCC1		C043561
CTD	increases(transport)			ABCC1		C043561
CTD	affects(export)			ABCC2		C043561
CTD	decreases(reaction)			ABCC2		C043561
CTD	decreases(activity)			ABCC2		C043561
CTD	decreases(export)			ABCC2		C043561
CTD	increases(expression)			ABCC2		C043561
CTD	affects(reaction)			ABCC3		C043561
CTD	increases(transport)			ABCC3		C043561
CTD	affects(reaction)			ABCC5		C043561
CTD	increases(transport)			ABCC5		C043561
CTD	decreases(expression)			ABCC5		C043561
CTD	decreases(reaction)			ABCG2		C043561
CTD	increases(secretion)			ABCG2		C043561
CTD	increases(transport)			ABCG2		C043561
CTD	decreases(activity)			ABCG2		C043561
CTD	decreases(export)			ABCG2		C043561
CTD	decreases(expression)			ABCG2		C043561
CTD	increases(expression)			ABCG2		C043561
CTD	increases(expression)			ABCG2		C043561
CTD	affects(activity)			AHR		C043561
CTD	affects(binding)			AHR		C043561
CTD	increases(activity)			AHR		C043561
CTD	affects(cotreatment)			AHR		C043561
CTD	affects(binding)			AHR		C043561
CTD	decreases(reaction)			AHR		C043561
CTD	affects(binding)			AHR		C043561
CTD	increases(reaction)			AHR		C043561
CTD	decreases(expression)			AKR1B10		C043561
CTD	decreases(activity)			AKT1		C043561
CTD	decreases(phosphorylation)			AKT1		C043561
CTD	decreases(reaction)			AKT1		C043561
CTD	affects(binding)			ARNT		C043561
CTD	increases(reaction)			ARNT		C043561
CTD	decreases(expression)			BCL2		C043561
CTD	decreases(reaction)			BCL2		C043561
CTD	decreases(activity)			BCL2		C043561
CTD	decreases(phosphorylation)			BCL2		C043561
CTD	increases(activity)			BCL2		C043561
CTD	increases(cleavage)			BCL2		C043561
CTD	increases(degradation)			BCL2		C043561
CTD	decreases(response to substance)			BCL2		C043561
CTD	affects(cotreatment)			CASP1		C043561
CTD	decreases(reaction)			CASP1		C043561
CTD	increases(activity)			CASP1		C043561
CTD	decreases(reaction)			CASP3		C043561
CTD	increases(activity)			CASP3		C043561
CTD	increases(cleavage)			CASP3		C043561
CTD	decreases(reaction)			CASP3		C043561
CTD	increases(activity)			CASP3		C043561
CTD	increases(degradation)			CASP3		C043561
CTD	increases(reaction)			CASP3		C043561
CTD	increases(cleavage)			CASP3		C043561
CTD	decreases(reaction)			CASP8		C043561
CTD	increases(activity)			CASP8		C043561
CTD	increases(degradation)			CASP8		C043561
CTD	increases(reaction)			CASP8		C043561
CTD	increases(cleavage)			CASP9		C043561
CTD	decreases(expression)			CCNB1		C043561
CTD	increases(expression)			CDKN1A		C043561
CTD	decreases(expression)			CDKN2C		C043561
CTD	decreases(reaction)			CTNNB1		C043561
CTD	increases(cleavage)			CTNNB1		C043561
CTD	decreases(reaction)			CXCL8		C043561
CTD	increases(secretion)			CXCL8		C043561
CTD	increases(expression)			CXCL8		C043561
CTD	affects(binding)			CYP19A1		C043561
CTD	decreases(activity)			CYP19A1		C043561
CTD	decreases(activity)			CYP19A1		C043561
CTD	affects(binding)			CYP1A1		C043561
CTD	decreases(reaction)			CYP1A1		C043561
CTD	decreases(reaction)			CYP1A1		C043561
CTD	increases(activity)			CYP1A1		C043561
CTD	decreases(reaction)			CYP1A1		C043561
CTD	increases(activity)			CYP1A1		C043561
CTD	decreases(reaction)			CYP1A1		C043561
CTD	increases(expression)			CYP1A1		C043561
CTD	affects(binding)			CYP1A1		C043561
CTD	increases(reaction)			CYP1A1		C043561
CTD	decreases(activity)			CYP1A1		C043561
CTD	increases(expression)			CYP1A1		C043561
CTD	increases(expression)			CYP1A1		C043561
CTD	increases(metabolic processing)			CYP1A1		C043561
CTD	increases(chemical synthesis)			CYP1A1		C043561
CTD	decreases(activity)			CYP1A2		C043561
CTD	increases(metabolic processing)			CYP1A2		C043561
CTD	increases(chemical synthesis)			CYP1A2		C043561
CTD	affects(binding)			CYP1B1		C043561
CTD	decreases(activity)			CYP1B1		C043561
CTD	decreases(activity)			CYP1B1		C043561
CTD	increases(metabolic processing)			CYP1B1		C043561
CTD	increases(chemical synthesis)			CYP1B1		C043561
CTD	decreases(reaction)			CYP2C9		C043561
CTD	increases(hydroxylation)			CYP2C9		C043561
CTD	affects(binding)			CYP3A4		C043561
CTD	decreases(activity)			CYP3A4		C043561
CTD	decreases(reaction)			CYP3A4		C043561
CTD	increases(activity)			CYP3A4		C043561
CTD	increases(expression)			EDN1		C043561
CTD	affects(binding)			ESR1		C043561
CTD	increases(activity)			ESR1		C043561
CTD	affects(binding)			ESR1		C043561
CTD	increases(reaction)			ESR1		C043561
CTD	affects(binding)			ESR2		C043561
CTD	increases(activity)			ESR2		C043561
CTD	affects(binding)			ESR2		C043561
CTD	decreases(expression)			FADS2		C043561
CTD	decreases(expression)			FBP1		C043561
CTD	affects(binding)			FOS		C043561
CTD	decreases(reaction)			FOS		C043561
CTD	increases(activity)			FOS		C043561
CTD	increases(expression)			GADD45B		C043561
CTD	decreases(expression)			HLA-DRA		C043561
CTD	decreases(expression)			HMOX1		C043561
CTD	decreases(reaction)			ICAM1		C043561
CTD	increases(expression)			ICAM1		C043561
CTD	decreases(expression)			IL15		C043561
CTD	affects(cotreatment)			IL1B		C043561
CTD	decreases(reaction)			IL1B		C043561
CTD	increases(expression)			IL1B		C043561
CTD	decreases(reaction)			IL1B		C043561
CTD	increases(phosphorylation)			IL1B		C043561
CTD	increases(secretion)			IL1B		C043561
CTD	decreases(expression)			IL1B		C043561
CTD	decreases(expression)			IL1R1		C043561
CTD	affects(cotreatment)			IL4		C043561
CTD	decreases(reaction)			IL4		C043561
CTD	increases(expression)			IL4		C043561
CTD	affects(cotreatment)			IL6		C043561
CTD	decreases(reaction)			IL6		C043561
CTD	increases(expression)			IL6		C043561
CTD	decreases(expression)			IL6		C043561
CTD	increases(expression)			IL6		C043561
CTD	affects(binding)			JUN		C043561
CTD	decreases(reaction)			JUN		C043561
CTD	increases(activity)			JUN		C043561
CTD	increases(expression)			JUN		C043561
CTD	decreases(reaction)			NFE2L2		C043561
CTD	decreases(response to substance)			NFE2L2		C043561
CTD	decreases(expression)			NFE2L2		C043561
CTD	affects(cotreatment)			NFKBIA		C043561
CTD	decreases(reaction)			NFKBIA		C043561
CTD	increases(degradation)			NFKBIA		C043561
CTD	decreases(reaction)			NFKBIA		C043561
CTD	increases(phosphorylation)			NFKBIA		C043561
CTD	decreases(reaction)			PLCG1		C043561
CTD	increases(degradation)			PLCG1		C043561
CTD	decreases(expression)			PPARA		C043561
CTD	decreases(expression)			PSCA		C043561
CTD	increases(expression)			PTGS2		C043561
CTD	decreases(reaction)			RELA		C043561
CTD	increases(activity)			RELA		C043561
CTD	affects(cotreatment)			RELA		C043561
CTD	affects(localization)			RELA		C043561
CTD	decreases(reaction)			RELA		C043561
CTD	decreases(expression)			SC5D		C043561
CTD	decreases(expression)			SCD		C043561
CTD	increases(expression)			SFN		C043561
CTD	increases(sulfation)			SULT1A1		C043561
CTD	decreases(activity)			SULT1E1		C043561
CTD	increases(sulfation)			SULT1E1		C043561
CTD	decreases(activity)			TBK1		C043561
CTD	affects(binding)			TFF1		C043561
CTD	increases(reaction)			TFF1		C043561
CTD	affects(cotreatment)			TNF		C043561
CTD	decreases(reaction)			TNF		C043561
CTD	increases(expression)			TNF		C043561
CTD	increases(secretion)			TNF		C043561
CTD	affects(binding)			TNF		C043561
CTD	decreases(reaction)			TNF		C043561
CTD	increases(activity)			TNF		C043561
CTD	increases(expression)			TNF		C043561
CTD	increases(degradation)			TNFSF10		C043561
CTD	increases(reaction)			TNFSF10		C043561
CTD	increases(response to substance)			TNFSF10		C043561
CTD	increases(degradation)			TP53		C043561
CTD	increases(expression)			TP53I3		C043561
CTD	increases(expression)			TP63		C043561
CTD	increases(expression)			TP73		C043561
CTD	decreases(reaction)			UGT1A1		C043561
CTD	increases(expression)			UGT1A1		C043561
CTD	affects(binding)			UGT1A1		C043561
CTD	affects(glucuronidation)			UGT1A1		C043561
CTD	increases(reaction)			UGT1A1		C043561
CTD	increases(glucuronidation)			UGT1A1		C043561
CTD	increases(reaction)			UGT1A1		C043561
CTD	increases(expression)			UGT1A1		C043561
CTD	increases(expression)			UGT1A1		C043561
CTD	increases(expression)			UGT1A1		C043561
CTD	increases(glucuronidation)			UGT1A1		C043561
CTD	increases(glucuronidation)			UGT1A10		C043561
CTD	affects(glucuronidation)			UGT1A6		C043561
CTD	increases(glucuronidation)			UGT1A7		C043561
CTD	increases(glucuronidation)			UGT1A8		C043561
CTD	affects(glucuronidation)			UGT1A9		C043561
CTD	increases(glucuronidation)			UGT1A9		C043561
CTD	increases(metabolic processing)			UGT2B15		C043561
CTD	increases(expression)			UTRN		C043561
CTD	increases(expression)			VCAM1		C043561
CTD	decreases(expression)			XIAP		C043561
CTD	decreases(reaction)			XIAP		C043561
PubChem	AhR Potency (uM)	uM	10.871	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	12.197	AHR	-	GI(Protien) :
PubChem	Potency	uM	39.811	AHR	-	GI(Protien) :
PubChem	None	uM		AKR1C4	-	GI(Protien) :
PubChem	Potency	uM	8.912	ALDH1A1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	30.638	CYP19A1	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	0.794	CYP2C19	-	GI(Protien) :
PubChem	None	uM		CYP2C19	-	GI(Protien) :
PubChem	Potency	uM	2.512	CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	7.943	CYP3A4	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	13.804	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	18.765	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	19.331	ESR1	-	GI(Protien) :
PubChem	Potency	uM	6.310	HIF1A	-	GI(Protien) :
PubChem	Potency	uM	10.871	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	13.685	NFE2L2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	24.337	NFE2L2	-	GI(Protien) :
PubChem	None	uM		NR0B1	-	GI(Protien) :
PubChem	None	uM		NR0B1	-	GI(Protien) :
PubChem	None	uM		NR1H4	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	50.119	NR1I2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	19.494	NR3C1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	17.374	PPARG	-	GI(Protien) :
PubChem	None	uM		PPARG	-	GI(Protien) :
PubChem	None	uM		SMARCA2	-	GI(Protien) :
PubChem	Potency	uM	3.981	SMN2	-	GI(Protien) :
PubChem	None	uM		STK16	-	GI(Protien) :
PubChem	Potency	uM	18.356	TDP1	-	GI(Protien) :
PubChem	None	uM		VDR	-	GI(Protien) :
ChEMBL	Potency	nM	8912.500	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	IC50	-		AR	-	Target : CHEMBL1871
ChEMBL	Inhibition	-		CYBB	-	Target : CHEMBL1287627
ChEMBL	Inhibition	-		CYBB	-	Target : CHEMBL1287627
ChEMBL	Inhibition	-		CYBB	-	Target : CHEMBL1287627
ChEMBL	Inhibition	-		CYBB	-	Target : CHEMBL1287627
ChEMBL	AC50	nM	19.950	CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP1B1	-	Target : CHEMBL4878
ChEMBL	AC50	nM	794.330	CYP2C19	-	Target : CHEMBL3622
ChEMBL	Potency	nM	794.300	CYP2C19	-	Target : CHEMBL3622
ChEMBL	Potency	nM	2511.900	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	7943.300	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	6309.600	HIF1A	-	Target : CHEMBL4261
ChEMBL	Activity	-		NR3C1	-	Target : CHEMBL2034
ChEMBL	Potency	nM	3981.100	SMN1; SMN2	-	Target : CHEMBL1293232
ChEMBL	ID50	-		TYR	-	Target : CHEMBL1973

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