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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : CTD - 3,3',4,5'-tetrahydroxystilbene

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Collection	D4 : CTD
Chemical Name	3,3',4,5'-tetrahydroxystilbene ( From PubChem : IN1152 )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 244.243 g/mol 4 4 2.6794 True
Structure
InChI	InChI=1S/C14H12O4/c15-11-5-10(6-12(16)8-11)2-1-9-3-4-13(17)14(18)7-9/h1-8,15-18H/b2-1+
InChIKey	CDRPUGZCRXZLFL-OWOJBTEDSA-N
Links
Gene (88 / 216) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD decreases(reaction) ABCC1 C041525 CTD increases(transport) ABCC1 C041525 CTD decreases(activity) ABCC1 C041525 CTD affects(binding) AHR C041525 CTD decreases(reaction) AHR C041525 CTD increases(reaction) AHR C041525 CTD affects(localization) AIFM1 C041525 CTD decreases(reaction) AIFM1 C041525 CTD decreases(activity) AMD1 C041525 CTD decreases(secretion) APP C041525 CTD affects(binding) ARNT C041525 CTD decreases(reaction) ARNT C041525 CTD increases(reaction) ARNT C041525 CTD increases(phosphorylation) ATM C041525 CTD increases(reaction) ATM C041525 CTD affects(cotreatment) CASP3 C041525 CTD increases(activity) CASP3 C041525 CTD increases(cleavage) CASP3 C041525 CTD increases(activity) CASP3 C041525 CTD increases(cleavage) CASP8 C041525 CTD increases(cleavage) CASP9 C041525 CTD decreases(expression) CCL11 C041525 CTD decreases(secretion) CCL11 C041525 CTD decreases(reaction) CCND1 C041525 CTD increases(expression) CCND1 C041525 CTD decreases(reaction) CHUK C041525 CTD increases(activity) CHUK C041525 CTD decreases(expression) CTNNB1 C041525 CTD increases(activity) CTNNB1 C041525 CTD affects(cotreatment) CXCL8 C041525 CTD decreases(reaction) CXCL8 C041525 CTD increases(expression) CXCL8 C041525 CTD affects(binding) CYP1A1 C041525 CTD decreases(reaction) CYP1A1 C041525 CTD increases(reaction) CYP1A1 C041525 CTD affects(chemical synthesis) CYP1A1 C041525 CTD affects(chemical synthesis) CYP1A2 C041525 CTD affects(binding) CYP1B1 C041525 CTD decreases(reaction) CYP1B1 C041525 CTD increases(reaction) CYP1B1 C041525 CTD affects(chemical synthesis) CYP1B1 C041525 CTD decreases(activity) DIO2 C041525 CTD decreases(expression) EGLN1 C041525 CTD increases(activity) EGLN1 C041525 CTD affects(localization) ENDOG C041525 CTD decreases(reaction) ENDOG C041525 CTD affects(binding) ESR1 C041525 CTD increases(activity) ESR1 C041525 CTD affects(binding) ESR1 C041525 CTD increases(reaction) ESR1 C041525 CTD increases(activity) ESR2 C041525 CTD decreases(reaction) ESR2 C041525 CTD increases(activity) FOS C041525 CTD increases(expression) FOS C041525 CTD affects(binding) GREB1 C041525 CTD increases(reaction) GREB1 C041525 CTD increases(activity) HIF1A C041525 CTD increases(expression) HIF1A C041525 CTD decreases(reaction) ICAM1 C041525 CTD increases(expression) ICAM1 C041525 CTD increases(secretion) ICAM1 C041525 CTD affects(cotreatment) IFNG C041525 CTD decreases(reaction) IFNG C041525 CTD increases(expression) IFNG C041525 CTD decreases(reaction) IKBKB C041525 CTD increases(activity) IKBKB C041525 CTD decreases(activity) IKBKB C041525 CTD increases(metabolic processing) IKBKB C041525 CTD decreases(activity) INSR C041525 CTD increases(expression) JUN C041525 CTD decreases(reaction) MMP9 C041525 CTD increases(expression) MMP9 C041525 CTD decreases(expression) MYC C041525 CTD decreases(expression) MYC C041525 CTD increases(activity) MYC C041525 CTD affects(binding) NCOA3 C041525 CTD increases(reaction) NCOA3 C041525 CTD affects(binding) NFKB1 C041525 CTD decreases(reaction) NFKB1 C041525 CTD increases(activity) NFKB1 C041525 CTD decreases(reaction) NFKBIA C041525 CTD increases(degradation) NFKBIA C041525 CTD increases(phosphorylation) NFKBIA C041525 CTD decreases(reaction) NFKBIA C041525 CTD increases(phosphorylation) NFKBIA C041525 CTD decreases(reaction) NFKBIA C041525 CTD increases(phosphorylation) NFKBIA C041525 CTD decreases(activity) ODC1 C041525 CTD decreases(expression) ODC1 C041525 CTD decreases(expression) PROS1 C041525 CTD affects(binding) PTGS2 C041525 CTD decreases(activity) PTGS2 C041525 CTD decreases(reaction) PTGS2 C041525 CTD increases(expression) PTGS2 C041525 CTD decreases(reaction) PTGS2 C041525 CTD increases(expression) PTGS2 C041525 CTD decreases(reaction) PTGS2 C041525 CTD increases(expression) PTGS2 C041525 CTD affects(localization) RAC1 C041525 CTD affects(localization) RELA C041525 CTD decreases(reaction) RELA C041525 CTD affects(localization) RELA C041525 CTD decreases(reaction) RELA C041525 CTD increases(phosphorylation) RELA C041525 CTD affects(binding) RELA C041525 CTD increases(activity) RELA C041525 CTD increases(activity) SIRT1 C041525 CTD decreases(expression) SIRT1 C041525 CTD increases(activity) SIRT1 C041525 CTD increases(expression) SIRT1 C041525 CTD decreases(activity) SOD2 C041525 CTD decreases(expression) SOD2 C041525 CTD decreases(reaction) STS C041525 CTD increases(activity) STS C041525 CTD decreases(reaction) SYK C041525 CTD increases(phosphorylation) SYK C041525 CTD decreases(abundance) SYK C041525 CTD decreases(activity) SYK C041525 CTD decreases(reaction) TNF C041525 CTD increases(expression) TNF C041525 CTD affects(cotreatment) TNF C041525 CTD decreases(reaction) TNF C041525 CTD increases(expression) TNF C041525 CTD affects(localization) TNF C041525 CTD increases(phosphorylation) TNF C041525 CTD increases(activity) TNF C041525 CTD affects(binding) TNF C041525 CTD decreases(response to substance) TNF C041525 CTD decreases(reaction) TNFRSF10B C041525 CTD increases(expression) TNFRSF10B C041525 CTD affects(cotreatment) TNFSF10 C041525 CTD increases(activity) TNFSF10 C041525 PubChem AC50_uM uM 1.200 CASP6 - GI(Protien) : PubChem None uM CASP6 - GI(Protien) : PubChem None uM ERAP1 - GI(Protien) : PubChem AbsAC1_uM uM 11.890 FGF22 - GI(Protien) : PubChem None uM FGF22 - GI(Protien) : PubChem None uM NR0B1 - GI(Protien) : PubChem None uM PSIP1 - GI(Protien) : PubChem None uM PSIP1 - GI(Protien) : PubChem None uM PSIP1 - GI(Protien) : PubChem None uM TRA - GI(Protien) : PubChem None uM WHSC1 - GI(Protien) : PubChem Potency uM 23.934 ARSA - GI(Protien) : PubChem Potency uM 3.661 ATAD5 - GI(Protien) : PubChem Potency uM 5.171 ATAD5 - GI(Protien) : PubChem None uM CASP3 - GI(Protien) : PubChem Potency uM 15.849 CBX1 - GI(Protien) : PubChem Potency uM 44.668 CBX1 - GI(Protien) : PubChem None uM CHRM1 - GI(Protien) : PubChem Potency uM 0.580 DRD1 - GI(Protien) : PubChem Potency uM 0.316 EHMT2 - GI(Protien) : PubChem Potency uM 0.670 EHMT2 - GI(Protien) : PubChem Potency uM 1.413 EHMT2 - GI(Protien) : PubChem Potency uM 2.818 EHMT2 - GI(Protien) : PubChem Potency uM 0.844 FEN1 - GI(Protien) : PubChem Potency uM 0.844 FEN1 - GI(Protien) : PubChem None uM GEM - GI(Protien) : PubChem AC50_uM uM 0.689 GFER - GI(Protien) : PubChem None uM GFER - GI(Protien) : PubChem Potency uM 1.995 GLS - GI(Protien) : PubChem AC50_uM uM 38.780 GSK3A - GI(Protien) : PubChem None uM HSP90AA1 - GI(Protien) : PubChem Potency uM 1.778 MAPT - GI(Protien) : PubChem Potency uM 5.012 MAPT - GI(Protien) : PubChem Potency uM 6.310 MAPT - GI(Protien) : PubChem Potency uM 7.080 MAPT - GI(Protien) : PubChem None uM MITF - GI(Protien) : PubChem Potency uM 39.811 MPHOSPH8 - GI(Protien) : PubChem None uM NAE1 - GI(Protien) : PubChem None uM PIM1 - GI(Protien) : PubChem Potency uM 7.943 POLB - GI(Protien) : PubChem Potency uM 17.783 POLH - GI(Protien) : PubChem Potency uM 15.849 POLI - GI(Protien) : PubChem Potency uM 2.818 POLK - GI(Protien) : PubChem Potency uM 31.623 POLK - GI(Protien) : PubChem Potency uM 79.433 POLK - GI(Protien) : PubChem Potency uM 21.192 RGS4 - GI(Protien) : PubChem None uM SENP6 - GI(Protien) : PubChem None uM SENP6 - GI(Protien) : PubChem None uM SENP7 - GI(Protien) : PubChem None uM SENP8 - GI(Protien) : PubChem None uM SENP8 - GI(Protien) : PubChem Potency uM 31.623 SMN2 - GI(Protien) : PubChem EC50_uM uM 12.790 STK33 - GI(Protien) : PubChem None uM STK33 - GI(Protien) : PubChem None uM STK33 - GI(Protien) : PubChem None uM STK33 - GI(Protien) : PubChem Potency uM 0.651 TDP1 - GI(Protien) : PubChem Potency uM 9.200 TDP1 - GI(Protien) : PubChem Potency uM 10.322 TDP1 - GI(Protien) : PubChem Potency uM 50.119 THRB - GI(Protien) : PubChem None uM UBE2M - GI(Protien) : ChEMBL Potency nM 4466.800 ALOX15B - Target : CHEMBL2457 ChEMBL Potency nM 5171.400 ATAD5 - Target : CHEMBL1741209 ChEMBL Potency nM 3661.100 ATAD5 - Target : CHEMBL1741209 ChEMBL Potency nM 44668.400 CBX1 - Target : CHEMBL1741193 ChEMBL Potency nM 580.400 DRD1 - Target : CHEMBL2056 ChEMBL Potency nM 2818.400 EHMT2 - Target : CHEMBL6032 ChEMBL Potency nM 316.200 EHMT2 - Target : CHEMBL6032 ChEMBL Potency nM 1412.500 EHMT2 - Target : CHEMBL6032 ChEMBL Potency nM 670.200 EHMT2 - Target : CHEMBL6032 ChEMBL Potency nM 843.700 FEN1 - Target : CHEMBL5027 ChEMBL AC50 nM 689.000 GFER - Target : CHEMBL1741189 ChEMBL Potency nM 44668.400 KDM4A - Target : CHEMBL5896 ChEMBL Potency nM 11220.200 MAPT - Target : CHEMBL1293224 ChEMBL Potency nM 8912.500 MAPT - Target : CHEMBL1293224 ChEMBL Potency nM 7079.500 MAPT - Target : CHEMBL1293224 ChEMBL Potency nM 5011.900 MAPT - Target : CHEMBL1293224 ChEMBL Potency nM 7943.300 MAPT - Target : CHEMBL1293224 ChEMBL Potency nM 1778.300 MAPT - Target : CHEMBL1293224 ChEMBL Potency nM 6309.600 MAPT - Target : CHEMBL1293224 ChEMBL Potency nM 39810.700 MPHOSPH8 - Target : CHEMBL1741210 ChEMBL Potency nM 7943.300 POLB - Target : CHEMBL2392 ChEMBL Potency nM 31622.800 SMN1; SMN2 - Target : CHEMBL1293232 ChEMBL Potency nM 50118.700 THRB - Target : CHEMBL1947
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