Tan Lab | DSigDB

Gene Set: D4 : CTD - harman

Collection

D4 : CTD

Chemical Name

harman ( From PubChem : HARMAN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
182.221 g/mol	1	1	3.0245	True

Structure

InChI

InChI=1S/C12H10N2/c1-8-12-10(6-7-13-8)9-4-2-3-5-11(9)14-12/h2-7,14H,1H3

InChIKey

Links

Gene (10 / 27)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			AHR		C005010
CTD	increases(activity)			AHR		C005010
CTD	increases(expression)			AHR		C005010
CTD	decreases(reaction)			CYP1A1		C005010
CTD	increases(activity)			CYP1A1		C005010
CTD	increases(expression)			CYP1A1		C005010
PubChem	Potency	uM	9.196	ATAD5	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	10.000	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	3.981	CYP3A4	-	GI(Protien) :
PubChem	None	uM		CYP3A4	-	GI(Protien) :
PubChem	None	uM		KLK7	-	GI(Protien) :
PubChem	None	uM		KLK7	-	GI(Protien) :
PubChem	AC50_uM	uM	58.370	RAD54L	-	GI(Protien) :
PubChem	Potency	uM	23.715	TDP1	-	GI(Protien) :
ChEMBL	Potency	nM	9196.200	ATAD5	-	Target : CHEMBL1741209
ChEMBL	AC50	nM	630.960	CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	1258.930	CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	10000.000	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	10000.000	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	3981.070	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	3981.100	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	15848.900	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	25118.900	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	25118.900	HSD17B10	-	Target : CHEMBL4159

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