Tan Lab | DSigDB

Gene Set: D4 : CTD - isoliquiritigenin

Collection

D4 : CTD

Chemical Name

isoliquiritigenin ( From PubChem : ISOLIQUIRITIGENIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
256.253 g/mol	3	4	2.6995	True

Structure

InChI

InChI=1S/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3+

InChIKey

DXDRHHKMWQZJHT-FPYGCLRLSA-N

Links

Gene (35 / 70)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(activity)			AKT1		C040920
CTD	decreases(reaction)			AKT1		C040920
CTD	decreases(response to substance)			AKT1		C040920
CTD	decreases(phosphorylation)			AKT1		C040920
CTD	decreases(phosphorylation)			BCL2		C040920
CTD	decreases(expression)			BCL2L1		C040920
CTD	decreases(phosphorylation)			BCL2L1		C040920
CTD	decreases(expression)			BIRC2		C040920
CTD	decreases(expression)			BIRC3		C040920
CTD	decreases(reaction)			CASP3		C040920
CTD	increases(cleavage)			CASP3		C040920
CTD	increases(activity)			CASP3		C040920
CTD	increases(activity)			CASP3		C040920
CTD	increases(activity)			CASP9		C040920
CTD	increases(cleavage)			CASP9		C040920
CTD	decreases(reaction)			CYP4A11		C040920
CTD	increases(secretion)			CYP4A11		C040920
CTD	decreases(expression)			CYP4A11		C040920
CTD	decreases(phosphorylation)			NFKBIA		C040920
CTD	increases(expression)			NFKBIA		C040920
CTD	decreases(reaction)			PARP1		C040920
CTD	increases(cleavage)			PARP1		C040920
CTD	decreases(expression)			PLA2G5		C040920
CTD	decreases(expression)			PTGS2		C040920
CTD	affects(localization)			RELA		C040920
CTD	decreases(activity)			RELA		C040920
CTD	affects(transport)			SLC2A1		C040920
CTD	decreases(reaction)			SLC2A1		C040920
CTD	decreases(activity)			SLC2A1		C040920
CTD	increases(glucuronidation)			UGT1A1		C040920
CTD	increases(glucuronidation)			UGT1A10		C040920
CTD	increases(glucuronidation)			UGT1A7		C040920
CTD	increases(glucuronidation)			UGT1A8		C040920
CTD	increases(glucuronidation)			UGT1A9		C040920
PubChem	None	uM		AHR	-	GI(Protien) :
PubChem	Potency	uM	8.196	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	3.981	CYP2C19	-	GI(Protien) :
PubChem	Potency	uM	10.000	CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	1.778	GBA	-	GI(Protien) :
PubChem	Potency	uM	3.981	GBA	-	GI(Protien) :
PubChem	Potency	uM	4.467	GBA	-	GI(Protien) :
PubChem	Potency	uM	11.220	GBA	-	GI(Protien) :
PubChem	Potency	uM	11.220	GBA	-	GI(Protien) :
PubChem	Potency	uM	10.000	GLS	-	GI(Protien) :
PubChem	Potency	uM	14.581	GMNN	-	GI(Protien) :
PubChem	Potency	uM	25.929	IDH1	-	GI(Protien) :
PubChem	Potency	uM	3.981	KCNH2		GI(Protien) :
PubChem	Potency	uM	3.981	KCNH2		GI(Protien) :
PubChem	Potency	uM	7.943	MAPT	-	GI(Protien) :
PubChem	Potency	uM	10.000	MAPT	-	GI(Protien) :
PubChem	Potency	uM	11.220	MAPT	-	GI(Protien) :
PubChem	None	uM		P4HB	-	GI(Protien) :
PubChem	None	uM		SMARCA2	-	GI(Protien) :
PubChem	None	uM		SMARCA2	-	GI(Protien) :
PubChem	Potency	uM	12.995	TDP1	-	GI(Protien) :
PubChem	Potency	uM	79.433	USP1	-	GI(Protien) :
PubChem	Potency	uM	79.433	VDR	-	GI(Protien) :
ChEMBL	Potency	nM	8196.100	ATAD5	-	Target : CHEMBL1741209
ChEMBL	Potency	nM	3981.100	CYP2C19	-	Target : CHEMBL3622
ChEMBL	Potency	nM	10000.000	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	11220.200	GBA	-	Target : CHEMBL2179
ChEMBL	Potency	nM	4466.800	GBA	-	Target : CHEMBL2179
ChEMBL	Potency	nM	11220.200	GBA	-	Target : CHEMBL2179
ChEMBL	Potency	nM	3981.100	GBA	-	Target : CHEMBL2179
ChEMBL	Potency	nM	1778.300	GBA	-	Target : CHEMBL2179
ChEMBL	Inhibition	-		JUN	-	Target : CHEMBL4977
ChEMBL	Potency	nM	11220.200	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	10000.000	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	7943.300	MAPT	-	Target : CHEMBL1293224
ChEMBL	Inhibition	-		RELA	-	Target : CHEMBL5533

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