Tan Lab | DSigDB

Gene Set: D4 : CTD - 1,2-naphthoquinone

Collection

D4 : CTD

Chemical Name

1,2-naphthoquinone ( From PubChem : 1,2-NAPHTHOQUINONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
158.153 g/mol	0	2	1.4652	True

Structure

InChI

InChI=1S/C10H6O2/c11-9-6-5-7-3-1-2-4-8(7)10(9)12/h1-6H

InChIKey

KETQAJRQOHHATG-UHFFFAOYSA-N

Links

Gene (39 / 79)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(reduction)			AKR1A1		C040756
CTD	increases(reduction)			AKR1B1		C040756
CTD	increases(reduction)			AKR7A2		C040756
CTD	decreases(reaction)			CAT		C040756
CTD	increases(expression)			CAT		C040756
CTD	increases(reaction)			CAT		C040756
CTD	affects(binding)			CBR1		C040756
CTD	increases(metabolic processing)			CBR1		C040756
CTD	increases(reaction)			CBR1		C040756
CTD	affects(binding)			CREB1		C040756
CTD	decreases(activity)			CREB1		C040756
CTD	increases(expression)			CXCL8		C040756
CTD	decreases(reaction)			CXCL8		C040756
CTD	increases(expression)			CXCL8		C040756
CTD	increases(reduction)			DHRS7		C040756
CTD	increases(activity)			EGFR		C040756
CTD	increases(phosphorylation)			EGFR		C040756
CTD	increases(stability)			FOS		C040756
CTD	affects(binding)			GAPDH		C040756
CTD	decreases(activity)			GAPDH		C040756
CTD	decreases(abundance)			GAPDH		C040756
CTD	increases(reaction)			GAPDH		C040756
CTD	increases(expression)			HMOX1		C040756
CTD	increases(reaction)			HMOX1		C040756
CTD	increases(phosphorylation)			MAPK1		C040756
CTD	decreases(reaction)			MAPK1		C040756
CTD	increases(phosphorylation)			MAPK3		C040756
CTD	decreases(reaction)			MAPK3		C040756
CTD	affects(binding)			PRDX6		C040756
CTD	decreases(activity)			PRDX6		C040756
CTD	increases(expression)			PTGS2		C040756
CTD	decreases(reaction)			PTGS2		C040756
CTD	decreases(activity)			PTPN1		C040756
CTD	affects(binding)			TOP2A		C040756
CTD	decreases(activity)			TOP2A		C040756
CTD	increases(activity)			TRPA1		C040756
CTD	decreases(activity)			UCHL1		C040756
CTD	increases(metabolic processing)			UCHL1		C040756
CTD	decreases(reaction)			UCHL1		C040756
PubChem	None	uM		ABHD5	-	GI(Protien) :
PubChem	Potency	uM	14.125	ALDH1A1	-	GI(Protien) :
PubChem	None	uM		APAF1	-	GI(Protien) :
PubChem	Average IC50	uM	10.610	APOBEC3G	-	GI(Protien) :
PubChem	Potency	uM	39.811	BAZ2B	-	GI(Protien) :
PubChem	None	uM		CDC25B	-	GI(Protien) :
PubChem	None	uM		CDC25B	-	GI(Protien) :
PubChem	None	uM		CDC25B	-	GI(Protien) :
PubChem	None	uM		CDC25B	-	GI(Protien) :
PubChem	None	uM		CDC25B	-	GI(Protien) :
PubChem	None	uM		CDC25B	-	GI(Protien) :
PubChem	None	uM		CDC25B	-	GI(Protien) :
PubChem	None	uM		DLD	-	GI(Protien) :
PubChem	None	uM		DUSP1	-	GI(Protien) :
PubChem	None	uM		DUSP1	-	GI(Protien) :
PubChem	None	uM		DUSP1	-	GI(Protien) :
PubChem	None	uM		DUSP1	-	GI(Protien) :
PubChem	None	uM		DUSP1	-	GI(Protien) :
PubChem	Potency	uM	8.912	EHMT2	-	GI(Protien) :
PubChem	None	uM		GAPDH	-	GI(Protien) :
PubChem	Potency	uM	7.943	HPGD	-	GI(Protien) :
PubChem	Potency	uM	28.184	KAT2A	-	GI(Protien) :
PubChem	Potency	uM	2.512	MAPT	-	GI(Protien) :
PubChem	Potency	uM	4.467	MAPT	-	GI(Protien) :
PubChem	None	uM		MCL1	-	GI(Protien) :
PubChem	IC50	uM		MPI	-	GI(Protien) :
PubChem	IC50	uM		MPI	-	GI(Protien) :
PubChem	None	uM		PLIN5	-	GI(Protien) :
PubChem	None	uM		STAT3	-	GI(Protien) :
ChEMBL	Potency	nM	14125.400	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	39810.700	BAZ2B	-	Target : CHEMBL1741220
ChEMBL	Potency	nM	8912.500	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	7943.300	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	31622.800	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	3981.100	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	28183.800	KAT2A	-	Target : CHEMBL5501
ChEMBL	Potency	nM	14125.400	KDM4E	-	Target : CHEMBL1293226
ChEMBL	Potency	nM	2511.900	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	4466.800	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	28183.800	RECQL	-	Target : CHEMBL1293236

Download gene sets

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