Tan Lab | DSigDB

Gene Set: D4 : CTD - ethylisopropylamiloride

Collection

D4 : CTD

Chemical Name

ethylisopropylamiloride ( From PubChem : EIPA )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
299.76 g/mol	3	8	2.3423	True

Structure

InChI

InChI=1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)

InChIKey

QDERNBXNXJCIQK-UHFFFAOYSA-N

Links

Gene (19 / 44)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(uptake)			ALB		C039614
CTD	affects(binding)			AOC1		C039614
CTD	decreases(reaction)			AOC1		C039614
CTD	increases(degradation)			AOC1		C039614
CTD	decreases(activity)			AOC1		C039614
CTD	decreases(reaction)			CCL2		C039614
CTD	increases(expression)			CCL2		C039614
CTD	decreases(reaction)			CXCL8		C039614
CTD	increases(secretion)			CXCL8		C039614
CTD	decreases(reaction)			CXCL8		C039614
CTD	increases(expression)			CXCL8		C039614
CTD	decreases(activity)			CYP1A1		C039614
CTD	decreases(activity)			CYP1A2		C039614
CTD	decreases(activity)			CYP1B1		C039614
CTD	decreases(reaction)			IL1B		C039614
CTD	increases(secretion)			IL1B		C039614
CTD	affects(localization)			NFKB1		C039614
CTD	decreases(reaction)			NFKB1		C039614
CTD	increases(activity)			NFKB1		C039614
CTD	affects(localization)			RELA		C039614
CTD	decreases(reaction)			RELA		C039614
CTD	increases(activity)			RELA		C039614
CTD	decreases(activity)			SLC9A1		C039614
CTD	decreases(activity)			SLC9A1		C039614
CTD	increases(abundance)			SLC9A1		C039614
CTD	affects(expression)			SMN2		C039614
CTD	affects(splicing)			SMN2		C039614
CTD	increases(expression)			SRSF3		C039614
CTD	decreases(expression)			VEGFA		C039614
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		MRGPRX1	-	GI(Protien) :
PubChem	None	uM		MRGPRX1	-	GI(Protien) :
PubChem	EC50	uM	9.569	OPRD1	-	GI(Protien) :
PubChem	None	uM		OPRD1	-	GI(Protien) :
PubChem	None	uM		OPRD1	-	GI(Protien) :
PubChem	EC50	uM	9.569	OPRM1	-	GI(Protien) :
PubChem	None	uM		OPRM1	-	GI(Protien) :
PubChem	None	uM		OPRM1	-	GI(Protien) :
PubChem	AC50_uM	uM	20.940	PAX8	-	GI(Protien) :
PubChem	None	uM		PAX8	-	GI(Protien) :
PubChem	Potency	uM	7.308	TDP1	-	GI(Protien) :
PubChem	Potency	uM	20.596	TDP1	-	GI(Protien) :
ChEMBL	AC50	nM	1995.260	CYP1A2	-	Target : CHEMBL3356

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