Tan Lab | DSigDB

Gene Set: D4 : CTD - dihydroartemisinin

Collection

D4 : CTD

Chemical Name

dihydroartemisinin ( From PubChem : ARTENIMOL )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
284.348 g/mol	1	5	2.1867	True

Structure

InChI

InChI=1S/C15H24O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12+,13-,14-,15-/m1/s1

InChIKey

BJDCWCLMFKKGEE-ISOSDAIHSA-N

Links

Gene (27 / 46)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(cleavage)			CASP3		C039060
CTD	increases(expression)			CAT		C039060
CTD	increases(expression)			CDKN1A		C039060
CTD	decreases(activity)			CYP1A2		C039060
CTD	decreases(activity)			CYP2C19		C039060
CTD	decreases(activity)			CYP3A4		C039060
CTD	increases(expression)			DDIT3		C039060
CTD	increases(expression)			EGR1		C039060
CTD	increases(expression)			GADD45A		C039060
CTD	affects(expression)			GYPA		C039060
CTD	increases(expression)			HMOX1		C039060
CTD	affects(localization)			JUN		C039060
CTD	decreases(reaction)			JUN		C039060
CTD	increases(phosphorylation)			JUN		C039060
CTD	decreases(reaction)			MAPK1		C039060
CTD	increases(phosphorylation)			MAPK1		C039060
CTD	decreases(reaction)			MAPK3		C039060
CTD	increases(phosphorylation)			MAPK3		C039060
CTD	decreases(reaction)			MMP14		C039060
CTD	increases(expression)			MMP14		C039060
CTD	decreases(reaction)			MMP2		C039060
CTD	increases(activity)			MMP2		C039060
CTD	increases(expression)			MMP2		C039060
CTD	decreases(reaction)			MMP9		C039060
CTD	increases(activity)			MMP9		C039060
CTD	increases(expression)			MMP9		C039060
CTD	increases(secretion)			MMP9		C039060
CTD	decreases(reaction)			NFKBIA		C039060
CTD	increases(degradation)			NFKBIA		C039060
CTD	increases(expression)			PMAIP1		C039060
CTD	affects(localization)			PRKCA		C039060
CTD	decreases(reaction)			PRKCA		C039060
CTD	increases(phosphorylation)			PRKCA		C039060
CTD	affects(localization)			RELA		C039060
CTD	decreases(reaction)			RELA		C039060
CTD	increases(phosphorylation)			RELA		C039060
CTD	increases(expression)			SOD1		C039060
CTD	increases(expression)			SOD2		C039060
CTD	increases(phosphorylation)			TP53		C039060
PubChem	AR Potency (uM)	uM	0.438	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.496	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.535	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.477	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	9.521	ESR1	-	GI(Protien) :
PubChem	Potency	uM	0.041	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.094	TDP1	-	GI(Protien) :

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