DSigDB

Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

Home

Search Gene

Collection

Browse

Download

Help

DSigDB Home

Search Gene

Collections

Browse Gene Sets

Download

Help

Gene Set: D4 : CTD - 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid

---

Collection	D4 : CTD
Chemical Name	4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid ( From PubChem : TTNPB )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 348.478 g/mol 1 2 6.2943 False(3/4)
Structure
InChI	InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+
InChIKey	FOIVPCKZDPCJJY-JQIJEIRASA-N
Links
Gene (38 / 72) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD decreases(response to substance) AKT1 C038864 CTD increases(expression) BAX C038864 CTD increases(expression) BAX C038864 CTD decreases(expression) BCL2 C038864 CTD decreases(expression) BCL2 C038864 CTD increases(expression) CASP3 C038864 CTD increases(expression) CASP3 C038864 CTD increases(expression) CCNA2 C038864 CTD increases(reaction) CCNA2 C038864 CTD decreases(expression) CCND1 C038864 CTD increases(expression) CCND3 C038864 CTD increases(reaction) CCND3 C038864 CTD decreases(expression) CCND3 C038864 CTD increases(expression) CCNE1 C038864 CTD increases(reaction) CCNE1 C038864 CTD decreases(expression) CDKN2B C038864 CTD increases(reaction) CDKN2B C038864 CTD increases(activity) CYP19A1 C038864 CTD increases(expression) CYP19A1 C038864 CTD increases(expression) CYP26A1 C038864 CTD decreases(reaction) CYP26A1 C038864 CTD increases(reaction) IL2 C038864 CTD increases(secretion) IL2 C038864 CTD increases(activity) NR1H4 C038864 CTD increases(expression) NRL C038864 CTD affects(binding) RARA C038864 CTD increases(activity) RARA C038864 CTD affects(binding) RARB C038864 CTD increases(activity) RARB C038864 CTD affects(binding) RARG C038864 CTD increases(activity) RARG C038864 CTD increases(phosphorylation) RB1 C038864 CTD increases(reaction) RB1 C038864 CTD decreases(phosphorylation) RB1 C038864 CTD increases(activity) RXRA C038864 CTD increases(activity) STS C038864 CTD decreases(reaction) STS C038864 CTD increases(expression) TGM2 C038864 CTD increases(expression) TGM2 C038864 CTD decreases(reaction) TGM2 C038864 PubChem None uM ADAM17 - GI(Protien) : PubChem None uM CFTR - GI(Protien) : PubChem Potency uM 3.981 CYP2C19 - GI(Protien) : PubChem None uM CYP2C19 - GI(Protien) : PubChem Potency uM 0.013 CYP2D6 - GI(Protien) : PubChem None uM CYP2D6 - GI(Protien) : PubChem None uM DNMT1 - GI(Protien) : PubChem Potency uM 15.849 EHMT2 - GI(Protien) : PubChem None uM FASN - GI(Protien) : PubChem Potency uM 11.220 GMNN - GI(Protien) : PubChem None uM MDM2 - GI(Protien) : PubChem None uM MDM2 - GI(Protien) : PubChem None uM MDM4 - GI(Protien) : PubChem None uM MDM4 - GI(Protien) : PubChem Potency uM 27.306 NFE2L2 - GI(Protien) : PubChem Potency uM 10.000 NFKB1 - GI(Protien) : PubChem Potency uM 26.680 PLK1 - GI(Protien) : PubChem Potency uM 31.623 POLI - GI(Protien) : PubChem None uM PTGER2 - GI(Protien) : PubChem Potency uM 0.708 RXRA - GI(Protien) : PubChem Potency uM 31.623 USP1 - GI(Protien) : ChEMBL Potency nM 3981.100 CYP2C19 - Target : CHEMBL3622 ChEMBL AC50 nM 3981.070 CYP2C19 - Target : CHEMBL3622 ChEMBL AC50 nM 12.590 CYP2D6 - Target : CHEMBL289 ChEMBL Potency nM 12.600 CYP2D6 - Target : CHEMBL289 ChEMBL Potency nM 15848.900 EHMT2 - Target : CHEMBL6032 ChEMBL Potency nM 11220.200 GMNN - Target : CHEMBL1293278 ChEMBL Potency nM 25118.900 HSD17B10 - Target : CHEMBL4159 ChEMBL Potency nM 10000.000 NFKB1 - Target : CHEMBL3251 ChEMBL Activity - RARA - Target : CHEMBL2055 ChEMBL Activity - RARB - Target : CHEMBL2008 ChEMBL Activity - RARG - Target : CHEMBL2003
Download gene sets	gmt, text, Detailed text

Contact us
Tan Lab , Mail Stop 8117
12801 East 17th Avenue
Division of Medical Oncology , Department of Medicine
University of Colorado School of Medicine
Aurora, CO 80045, USA

* Best viewed in the latest version of Chrome (42+), Safari (8+), IE (11+) or Firefox (35+).