Tan Lab | DSigDB

Gene Set: D4 : CTD - nabumetone

Collection

D4 : CTD

Chemical Name

nabumetone ( From PubChem : NABUMETONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
228.286 g/mol	0	2	3.37	True

Structure

InChI

InChI=1S/C15H16O2/c1-11(16)3-4-12-5-6-14-10-15(17-2)8-7-13(14)9-12/h5-10H,3-4H2,1-2H3

InChIKey

Links

Gene (13 / 19)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(expression)			BCL2		C035605
CTD	increases(expression)			FOS		C035605
CTD	increases(expression)			HSPA7		C035605
CTD	affects(expression)			SELL		C035605
CTD	increases(expression)			UTRN		C035605
PubChem	Potency-Replicate_1	uM	3.201	AHR	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	1.274	ESR1	-	GI(Protien) :
PubChem	None	uM		ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	24.636	NFE2L2	-	GI(Protien) :
PubChem	None	uM		NR0B1	-	GI(Protien) :
PubChem	None	uM		NR0B1	-	GI(Protien) :
PubChem	None	uM		NR5A1	-	GI(Protien) :
PubChem	Potency	uM	11.220	SMN2	-	GI(Protien) :
PubChem	Potency	uM	12.589	SMN2	-	GI(Protien) :
ChEMBL	AC50	nM	398.110	CYP1A2	-	Target : CHEMBL3356
ChEMBL	Potency	nM	11220.200	SMN1; SMN2	-	Target : CHEMBL1293232
ChEMBL	Potency	nM	12589.300	SMN1; SMN2	-	Target : CHEMBL1293232

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