Tan Lab | DSigDB

Gene Set: D4 : CTD - 1,4-naphthoquinone

Collection

D4 : CTD

Chemical Name

1,4-naphthoquinone ( From PubChem : 1,4-NAPHTHOQUINONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
158.153 g/mol	0	2	1.6218	True

Structure

InChI

InChI=1S/C10H6O2/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-6H

InChIKey

Links

Gene (25 / 34)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(activity)			CASP3		C035342
CTD	increases(activity)			CASP8		C035342
CTD	affects(binding)			CBR1		C035342
CTD	decreases(reaction)			CBR1		C035342
CTD	increases(metabolic processing)			CBR1		C035342
CTD	increases(expression)			CCL2		C035342
CTD	increases(expression)			CXCL8		C035342
CTD	increases(abundance)			CYP1A1		C035342
CTD	increases(expression)			CYP1A2		C035342
CTD	increases(abundance)			CYP1A2		C035342
CTD	increases(abundance)			CYP1B1		C035342
CTD	increases(abundance)			CYP2B6		C035342
CTD	increases(abundance)			CYP2C18		C035342
CTD	increases(abundance)			CYP2C19		C035342
CTD	increases(abundance)			CYP2C8		C035342
CTD	increases(abundance)			CYP2C9		C035342
CTD	increases(abundance)			CYP2D6		C035342
CTD	increases(abundance)			CYP2E1		C035342
CTD	increases(expression)			CYP3A4		C035342
CTD	increases(abundance)			CYP3A4		C035342
CTD	increases(abundance)			CYP3A5		C035342
CTD	increases(abundance)			CYP3A7		C035342
CTD	increases(abundance)			CYP4A11		C035342
CTD	increases(expression)			TNF		C035342
CTD	affects(binding)			TOP2A		C035342
CTD	decreases(activity)			TOP2A		C035342
PubChem	Potency	uM	15.849	AHR	-	GI(Protien) :
PubChem	Potency	uM	54.483	NFE2L2	-	GI(Protien) :
ChEMBL	Inhibition	-		CASP3	-	Target : CHEMBL2334
ChEMBL	Inhibition	-		CASP3	-	Target : CHEMBL2334
ChEMBL	Inhibition	-		MAOA	-	Target : CHEMBL1951
ChEMBL	Inhibition	-		MAOA	-	Target : CHEMBL1951
ChEMBL	Inhibition	-		MAOB	-	Target : CHEMBL2039
ChEMBL	Inhibition	-		MAOB	-	Target : CHEMBL2039

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