Tan Lab | DSigDB

Gene Set: D4 : CTD - mirtazapine

Collection

D4 : CTD

Chemical Name

mirtazapine ( From PubChem : MIRTAZAPINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Approved	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
265.353 g/mol	0	3	2.4818	True

Structure

InChI

InChI=1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3/t16-/m0/s1

InChIKey

Links

Gene (11 / 25)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			HMGCS1		C035133
CTD	decreases(reaction)			HTR2C		C035133
CTD	increases(expression)			HTR2C		C035133
CTD	affects(activity)			HTR2C		C035133
CTD	affects(binding)			HTR2C		C035133
CTD	increases(expression)			PRL		C035133
CTD	increases(expression)			SCD		C035133
CTD	decreases(reaction)			SLC22A2		C035133
CTD	increases(uptake)			SLC22A2		C035133
CTD	increases(expression)			SLC2A4		C035133
CTD	increases(expression)			SLC2A5		C035133
CTD	increases(activity)			SREBF1		C035133
CTD	increases(cleavage)			SREBF1		C035133
PubChem	Potency	uM	0.050	CYP2C19	-	GI(Protien) :
PubChem	None	uM		CYP2C19	-	GI(Protien) :
PubChem	Potency	uM	0.050	CYP2C9	-	GI(Protien) :
PubChem	None	uM		CYP2C9	-	GI(Protien) :
PubChem	Potency	uM	0.501	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
ChEMBL	Potency	nM	50.100	CYP2C19	-	Target : CHEMBL3622
ChEMBL	AC50	nM	50.120	CYP2C19	-	Target : CHEMBL3622
ChEMBL	AC50	nM	50.120	CYP2C9	-	Target : CHEMBL3397
ChEMBL	Potency	nM	50.100	CYP2C9	-	Target : CHEMBL3397
ChEMBL	AC50	nM	501.190	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	501.200	CYP2D6	-	Target : CHEMBL289

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