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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : CTD - bis(4-hydroxycinnamoyl)methane

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Collection	D4 : CTD
Chemical Name	bis(4-hydroxycinnamoyl)methane ( From PubChem : 24939-16-0 )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 308.328 g/mol 2 4 3.3527 True
Structure
InChI	InChI=1S/C19H16O4/c20-16-7-1-14(2-8-16)5-11-18(22)13-19(23)12-6-15-3-9-17(21)10-4-15/h1-12,20-21H,13H2/b11-5+,12-6+
InChIKey	PREBVFJICNPEKM-YDWXAUTNSA-N
Links
Gene (22 / 33) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD decreases(activity) ABCC1 C034786 CTD decreases(activity) ABCC2 C034786 CTD affects(cotreatment) APP C034786 CTD increases(expression) APP C034786 CTD affects(binding) APP C034786 CTD decreases(reaction) APP C034786 CTD increases(expression) GCLM C034786 CTD increases(expression) HMOX1 C034786 CTD affects(cotreatment) MGAT3 C034786 CTD increases(expression) MGAT3 C034786 CTD increases(expression) MGAT3 C034786 CTD decreases(expression) MMP14 C034786 CTD decreases(activity) MMP2 C034786 CTD decreases(secretion) MMP2 C034786 CTD decreases(activity) MMP9 C034786 CTD decreases(secretion) MMP9 C034786 CTD increases(expression) NQO1 C034786 CTD decreases(secretion) PLAU C034786 CTD affects(binding) PPARG C034786 CTD decreases(expression) TIMP2 C034786 CTD affects(cotreatment) TLR2 C034786 CTD increases(expression) TLR2 C034786 CTD affects(cotreatment) TLR3 C034786 CTD increases(expression) TLR3 C034786 CTD affects(cotreatment) TLR4 C034786 CTD increases(expression) TLR4 C034786 CTD affects(cotreatment) VDR C034786 CTD increases(expression) VDR C034786 CTD decreases(expression) WT1 C034786 PubChem None uM STK33 - GI(Protien) : ChEMBL Activity - DNMT1 - Target : CHEMBL1993 ChEMBL Inhibition - SMAD2 - Target : CHEMBL2396512 ChEMBL Inhibition - SMAD3 - Target : CHEMBL1293258
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