Tan Lab | DSigDB

Gene Set: D4 : CTD - daidzein

Collection

D4 : CTD

Chemical Name

daidzein ( From PubChem : DAIDZEIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Approved	Not	Approved	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
254.238 g/mol	2	4	2.8712	True

Structure

InChI

InChI=1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H

InChIKey

ZQSIJRDFPHDXIC-UHFFFAOYSA-N

Links

Gene (127 / 293)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(cotreatment)			ABCA1		C004742
CTD	decreases(expression)			ABCA1		C004742
CTD	increases(hydrolysis)			ABCC1		C004742
CTD	increases(reaction)			ABCC1		C004742
CTD	decreases(reaction)			ABCC4		C004742
CTD	increases(export)			ABCC4		C004742
CTD	increases(hydrolysis)			ABCC4		C004742
CTD	increases(reaction)			ABCC4		C004742
CTD	decreases(reaction)			ABCC5		C004742
CTD	decreases(response to substance)			ABCC5		C004742
CTD	increases(export)			ABCC5		C004742
CTD	affects(cotreatment)			ADD2		C004742
CTD	decreases(expression)			ADD2		C004742
CTD	affects(binding)			AHR		C004742
CTD	affects(binding)			ALPL		C004742
CTD	increases(activity)			ALPL		C004742
CTD	decreases(reaction)			ALPL		C004742
CTD	increases(expression)			ALPPL2		C004742
CTD	increases(activity)			AR		C004742
CTD	increases(reaction)			AR		C004742
CTD	decreases(expression)			ARHGDIA		C004742
CTD	affects(cotreatment)			ATP6V0A2		C004742
CTD	decreases(expression)			ATP6V0A2		C004742
CTD	affects(cotreatment)			BAZ1A		C004742
CTD	increases(expression)			BAZ1A		C004742
CTD	decreases(expression)			BCL2		C004742
CTD	decreases(expression)			BCL2L1		C004742
CTD	affects(cotreatment)			BGLAP		C004742
CTD	increases(expression)			BGLAP		C004742
CTD	increases(expression)			BRCA1		C004742
CTD	increases(activity)			CASP3		C004742
CTD	decreases(expression)			CCNA2		C004742
CTD	increases(expression)			CCND1		C004742
CTD	affects(binding)			CDK2		C004742
CTD	increases(reaction)			CDK2		C004742
CTD	decreases(activity)			CDK2		C004742
CTD	decreases(activity)			CDK4		C004742
CTD	affects(binding)			CDKN1A		C004742
CTD	increases(reaction)			CDKN1A		C004742
CTD	increases(expression)			CDKN1A		C004742
CTD	affects(reaction)			CDKN1A		C004742
CTD	increases(activity)			CHAT		C004742
CTD	increases(activity)			CKB		C004742
CTD	decreases(reaction)			CKB		C004742
CTD	decreases(reaction)			COMT		C004742
CTD	increases(methylation)			COMT		C004742
CTD	decreases(activity)			COMT		C004742
CTD	decreases(expression)			COMT		C004742
CTD	decreases(reaction)			COMT		C004742
CTD	increases(expression)			COX7A2L		C004742
CTD	increases(expression)			CPT1A		C004742
CTD	affects(cotreatment)			CRP		C004742
CTD	decreases(expression)			CRP		C004742
CTD	increases(expression)			CXCL12		C004742
CTD	decreases(reaction)			CXCL12		C004742
CTD	decreases(reaction)			CXCL8		C004742
CTD	increases(expression)			CXCL8		C004742
CTD	decreases(expression)			CXCL8		C004742
CTD	decreases(activity)			CYP19A1		C004742
CTD	decreases(expression)			CYP19A1		C004742
CTD	affects(cotreatment)			CYP19A1		C004742
CTD	decreases(activity)			CYP19A1		C004742
CTD	decreases(reaction)			CYP1A1		C004742
CTD	increases(expression)			CYP1A1		C004742
CTD	decreases(activity)			CYP1A1		C004742
CTD	decreases(expression)			CYP1A1		C004742
CTD	affects(chemical synthesis)			CYP1B1		C004742
CTD	decreases(activity)			CYP1B1		C004742
CTD	decreases(reaction)			CYP21A2		C004742
CTD	increases(expression)			CYP21A2		C004742
CTD	decreases(activity)			CYP2C9		C004742
CTD	decreases(activity)			CYP2D6		C004742
CTD	decreases(activity)			CYP3A4		C004742
CTD	affects(cotreatment)			DOCK3		C004742
CTD	decreases(expression)			DOCK3		C004742
CTD	decreases(expression)			DUSP4		C004742
CTD	increases(expression)			EBAG9		C004742
CTD	affects(cotreatment)			EGFR		C004742
CTD	decreases(expression)			EGFR		C004742
CTD	decreases(expression)			ENO3		C004742
CTD	affects(cotreatment)			EPHA1		C004742
CTD	increases(expression)			EPHA1		C004742
CTD	affects(cotreatment)			ESPN		C004742
CTD	decreases(expression)			ESPN		C004742
CTD	affects(binding)			ESR1		C004742
CTD	increases(activity)			ESR1		C004742
CTD	affects(binding)			ESR1		C004742
CTD	affects(binding)			ESR1		C004742
CTD	increases(activity)			ESR1		C004742
CTD	affects(cotreatment)			ESR1		C004742
CTD	decreases(expression)			ESR1		C004742
CTD	increases(expression)			ESR1		C004742
CTD	affects(binding)			ESR1		C004742
CTD	decreases(reaction)			ESR1		C004742
CTD	affects(binding)			ESR1		C004742
CTD	increases(activity)			ESR1		C004742
CTD	increases(reaction)			ESR1		C004742
CTD	increases(activity)			ESR1		C004742
CTD	increases(reaction)			ESR1		C004742
CTD	decreases(expression)			ESR1		C004742
CTD	increases(activity)			ESR1		C004742
CTD	decreases(reaction)			ESR1		C004742
CTD	increases(expression)			ESR1		C004742
CTD	affects(activity)			ESR1		C004742
CTD	affects(reaction)			ESR1		C004742
CTD	decreases(reaction)			ESR1		C004742
CTD	affects(binding)			ESR2		C004742
CTD	increases(activity)			ESR2		C004742
CTD	affects(binding)			ESR2		C004742
CTD	affects(cotreatment)			ESR2		C004742
CTD	decreases(expression)			ESR2		C004742
CTD	increases(expression)			ESR2		C004742
CTD	affects(binding)			ESR2		C004742
CTD	decreases(reaction)			ESR2		C004742
CTD	decreases(reaction)			ESR2		C004742
CTD	increases(activity)			ESR2		C004742
CTD	affects(binding)			ESR2		C004742
CTD	increases(activity)			ESR2		C004742
CTD	increases(activity)			ESR2		C004742
CTD	increases(reaction)			ESR2		C004742
CTD	increases(activity)			ESR2		C004742
CTD	increases(activity)			ESR2		C004742
CTD	increases(expression)			ESR2		C004742
CTD	affects(reaction)			ESR2		C004742
CTD	increases(expression)			ESR2		C004742
CTD	affects(response to substance)			ESR2		C004742
CTD	affects(cotreatment)			ESR2		C004742
CTD	affects(expression)			ESR2		C004742
CTD	affects(reaction)			ESR2		C004742
CTD	affects(response to substance)			ESR2		C004742
CTD	affects(activity)			ESR2		C004742
CTD	affects(reaction)			ESR2		C004742
CTD	affects(binding)			ESRRA		C004742
CTD	increases(activity)			ESRRA		C004742
CTD	increases(reaction)			ESRRA		C004742
CTD	affects(binding)			ESRRB		C004742
CTD	increases(activity)			ESRRB		C004742
CTD	increases(reaction)			ESRRB		C004742
CTD	affects(binding)			ESRRG		C004742
CTD	increases(reaction)			ESRRG		C004742
CTD	affects(cotreatment)			FMN2		C004742
CTD	increases(expression)			FMN2		C004742
CTD	increases(expression)			FOS		C004742
CTD	increases(expression)			GREB1		C004742
CTD	decreases(reaction)			GREB1		C004742
CTD	decreases(reaction)			HSD3B2		C004742
CTD	increases(expression)			HSD3B2		C004742
CTD	affects(cotreatment)			IBSP		C004742
CTD	increases(expression)			IBSP		C004742
CTD	affects(cotreatment)			IFRD2		C004742
CTD	increases(expression)			IFRD2		C004742
CTD	decreases(expression)			IGF1R		C004742
CTD	increases(expression)			IGFBP4		C004742
CTD	decreases(reaction)			IL1B		C004742
CTD	increases(secretion)			IL1B		C004742
CTD	decreases(reaction)			IL6		C004742
CTD	increases(secretion)			IL6		C004742
CTD	affects(cotreatment)			IRF2BP1		C004742
CTD	increases(expression)			IRF2BP1		C004742
CTD	increases(expression)			JUN		C004742
CTD	decreases(reaction)			KAT5		C004742
CTD	increases(activity)			KAT5		C004742
CTD	affects(cotreatment)			KCNG2		C004742
CTD	increases(expression)			KCNG2		C004742
CTD	decreases(expression)			KLK3		C004742
CTD	decreases(expression)			LAMP3		C004742
CTD	decreases(reaction)			MAPK1		C004742
CTD	increases(phosphorylation)			MAPK1		C004742
CTD	decreases(reaction)			MAPK3		C004742
CTD	increases(phosphorylation)			MAPK3		C004742
CTD	increases(expression)			ME1		C004742
CTD	increases(expression)			MT2A		C004742
CTD	increases(expression)			MYC		C004742
CTD	affects(binding)			NCOA2		C004742
CTD	increases(reaction)			NCOA2		C004742
CTD	decreases(expression)			NKX3-1		C004742
CTD	increases(activity)			NOS3		C004742
CTD	decreases(expression)			NQO1		C004742
CTD	affects(binding)			NR1I2		C004742
CTD	increases(activity)			NR1I2		C004742
CTD	increases(expression)			NRIP1		C004742
CTD	affects(cotreatment)			OLFML3		C004742
CTD	increases(expression)			OLFML3		C004742
CTD	increases(cleavage)			PARP1		C004742
CTD	decreases(expression)			PCNA		C004742
CTD	affects(cotreatment)			PDLIM2		C004742
CTD	increases(expression)			PDLIM2		C004742
CTD	increases(expression)			PDZK1		C004742
CTD	increases(expression)			PGR		C004742
CTD	increases(expression)			PGR		C004742
CTD	decreases(reaction)			PGR		C004742
CTD	affects(cotreatment)			PNN		C004742
CTD	increases(expression)			PNN		C004742
CTD	affects(binding)			PNRC1		C004742
CTD	increases(reaction)			PNRC1		C004742
CTD	affects(cotreatment)			POU4F2		C004742
CTD	decreases(expression)			POU4F2		C004742
CTD	decreases(expression)			PRKCD		C004742
CTD	increases(expression)			PRSS23		C004742
CTD	decreases(reaction)			PRSS23		C004742
CTD	affects(cotreatment)			PTGS2		C004742
CTD	increases(expression)			PTGS2		C004742
CTD	decreases(reaction)			PTGS2		C004742
CTD	increases(expression)			PTGS2		C004742
CTD	increases(phosphorylation)			PTK2		C004742
CTD	increases(expression)			RBBP8		C004742
CTD	increases(expression)			RPS6KA3		C004742
CTD	affects(cotreatment)			SGPP1		C004742
CTD	decreases(expression)			SGPP1		C004742
CTD	decreases(expression)			SLC12A2		C004742
CTD	affects(transport)			SLC2A1		C004742
CTD	decreases(reaction)			SLC2A1		C004742
CTD	decreases(activity)			SLC2A1		C004742
CTD	increases(expression)			SLC7A5		C004742
CTD	affects(cotreatment)			STC1		C004742
CTD	decreases(expression)			STC1		C004742
CTD	decreases(expression)			STK39		C004742
CTD	decreases(reaction)			SULT1A1		C004742
CTD	increases(sulfation)			SULT1A1		C004742
CTD	decreases(reaction)			SULT1A3		C004742
CTD	increases(sulfation)			SULT1A3		C004742
CTD	affects(cotreatment)			TACR3		C004742
CTD	increases(expression)			TACR3		C004742
CTD	increases(expression)			TFF1		C004742
CTD	decreases(reaction)			TFF1		C004742
CTD	increases(expression)			TFF1		C004742
CTD	increases(activity)			TGFB1I1		C004742
CTD	increases(reaction)			TGFB1I1		C004742
CTD	affects(cotreatment)			TNFAIP6		C004742
CTD	decreases(expression)			TNFAIP6		C004742
CTD	increases(expression)			TP53		C004742
CTD	decreases(expression)			TP53I11		C004742
CTD	increases(expression)			TPD52L1		C004742
CTD	affects(cotreatment)			UCHL1		C004742
CTD	decreases(expression)			UCHL1		C004742
CTD	increases(activity)			UGT1A1		C004742
CTD	increases(glucuronidation)			UGT1A1		C004742
CTD	increases(glucuronidation)			UGT1A10		C004742
CTD	increases(glucuronidation)			UGT1A7		C004742
CTD	increases(glucuronidation)			UGT1A8		C004742
CTD	increases(glucuronidation)			UGT1A9		C004742
CTD	increases(expression)			UGT2B17		C004742
CTD	affects(cotreatment)			VCAM1		C004742
CTD	affects(expression)			VCAM1		C004742
CTD	affects(reaction)			VCAM1		C004742
PubChem	AhR Potency (uM)	uM	8.547	AHR	-	GI(Protien) :
PubChem	Potency	uM	20.588	ATAD5	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	10.000	CYP2C19	-	GI(Protien) :
PubChem	None	uM		CYP2C19	-	GI(Protien) :
PubChem	Potency	uM	6.310	CYP2C9	-	GI(Protien) :
PubChem	None	uM		CYP2C9	-	GI(Protien) :
PubChem	Potency	uM	15.849	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	0.794	ESR1	-	GI(Protien) :
PubChem	Potency	uM	0.891	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	1.520	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	3.059	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	4.322	ESR1	-	GI(Protien) :
PubChem	None	uM		MRGPRX1	-	GI(Protien) :
PubChem	Potency	uM	27.306	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	42.163	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	9.200	NPC1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	44.668	NR1I2	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
PubChem	None	uM		PIM2	-	GI(Protien) :
PubChem	Potency	uM	10.000	RAB9A	-	GI(Protien) :
PubChem	IC50	uM	91.260	RACGAP1	-	GI(Protien) :
PubChem	Potency	uM	12.589	SMN2	-	GI(Protien) :
PubChem	Potency	uM	15.849	SMN2	-	GI(Protien) :
PubChem	Potency	uM	28.184	SMN2	-	GI(Protien) :
PubChem	Potency	uM	10.000	TP53	-	GI(Protien) :
ChEMBL	Potency	nM	20587.800	ATAD5	-	Target : CHEMBL1741209
ChEMBL	AC50	nM	15848.900	CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	10000.000	CYP2C19	-	Target : CHEMBL3622
ChEMBL	Potency	nM	10000.000	CYP2C19	-	Target : CHEMBL3622
ChEMBL	Potency	nM	6309.600	CYP2C9	-	Target : CHEMBL3397
ChEMBL	AC50	nM	6309.570	CYP2C9	-	Target : CHEMBL3397
ChEMBL	AC50	nM	15848.900	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	15848.900	CYP2D6	-	Target : CHEMBL289
ChEMBL	Activity	-		ESR1	-	Target : CHEMBL206
ChEMBL	Activity	-		ESR1	-	Target : CHEMBL206
ChEMBL	Activity	-		ESR1	-	Target : CHEMBL206
ChEMBL	Potency	nM	25118.900	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	31622.800	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	31622.800	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	9200.000	NPC1	-	Target : CHEMBL1293277
ChEMBL	Potency	nM	10000.000	RAB9A	-	Target : CHEMBL1293294
ChEMBL	Potency	nM	12589.300	SMN1; SMN2	-	Target : CHEMBL1293232
ChEMBL	Potency	nM	28183.800	SMN1; SMN2	-	Target : CHEMBL1293232
ChEMBL	Potency	nM	15848.900	SMN1; SMN2	-	Target : CHEMBL1293232
ChEMBL	Potency	nM	10000.000	TP53	-	Target : CHEMBL4096

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