Tan Lab | DSigDB

Gene Set: D4 : CTD - 1-nitropyrene

Collection

D4 : CTD

Chemical Name

1-nitropyrene ( From PubChem : 1-NITROPYRENE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
247.248 g/mol	0	0	5.0154	False(3/4)

Structure

InChI

InChI=1S/C16H9NO2/c18-17(19)14-9-7-12-5-4-10-2-1-3-11-6-8-13(14)16(12)15(10)11/h1-9H

InChIKey

ALRLPDGCPYIVHP-UHFFFAOYSA-N

Links

Gene (234 / 283)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			ABCE1		C032668
CTD	increases(expression)			ABCF1		C032668
CTD	increases(expression)			ADAMTS1		C032668
CTD	increases(expression)			ADGRG6		C032668
CTD	increases(expression)			AFF4		C032668
CTD	increases(expression)			AFTPH		C032668
CTD	affects(binding)			AHR		C032668
CTD	decreases(response to substance)			AHR		C032668
CTD	increases(activity)			AHR		C032668
CTD	increases(expression)			AHR		C032668
CTD	increases(expression)			ALCAM		C032668
CTD	decreases(expression)			ANG		C032668
CTD	increases(expression)			ANTXR2		C032668
CTD	decreases(expression)			APCDD1		C032668
CTD	decreases(expression)			APOBEC3C		C032668
CTD	decreases(reaction)			AR		C032668
CTD	increases(activity)			AR		C032668
CTD	increases(expression)			ARFIP1		C032668
CTD	increases(expression)			ASNS		C032668
CTD	increases(expression)			ATP8B1		C032668
CTD	increases(expression)			BAX		C032668
CTD	affects(reaction)			BAX		C032668
CTD	increases(expression)			BCL2A1		C032668
CTD	increases(expression)			BIRC3		C032668
CTD	increases(expression)			BMP2		C032668
CTD	increases(expression)			BMPER		C032668
CTD	decreases(expression)			BRCA1		C032668
CTD	decreases(expression)			C1QTNF2		C032668
CTD	decreases(expression)			C1RL		C032668
CTD	increases(expression)			C5ORF34		C032668
CTD	decreases(expression)			CA6		C032668
CTD	increases(expression)			CBS		C032668
CTD	increases(expression)			CCDC18		C032668
CTD	decreases(expression)			CCL15		C032668
CTD	decreases(expression)			CCL17		C032668
CTD	decreases(expression)			CCL19		C032668
CTD	increases(expression)			CCL20		C032668
CTD	decreases(expression)			CCL21		C032668
CTD	decreases(expression)			CCL24		C032668
CTD	decreases(expression)			CCL26		C032668
CTD	increases(expression)			CCL5		C032668
CTD	increases(expression)			CCND1		C032668
CTD	increases(expression)			CCR4		C032668
CTD	decreases(expression)			CCR6		C032668
CTD	decreases(expression)			CCR7		C032668
CTD	decreases(expression)			CCR8		C032668
CTD	decreases(expression)			CD14		C032668
CTD	decreases(expression)			CD8B		C032668
CTD	decreases(expression)			CDH1		C032668
CTD	increases(expression)			CDH13		C032668
CTD	decreases(expression)			CDH3		C032668
CTD	increases(expression)			CDK17		C032668
CTD	increases(expression)			CDKN1A		C032668
CTD	increases(expression)			CDKN1A		C032668
CTD	decreases(response to substance)			CDKN1A		C032668
CTD	increases(expression)			CEBPB		C032668
CTD	decreases(expression)			CEBPD		C032668
CTD	increases(expression)			CEBPG		C032668
CTD	decreases(expression)			CENPB		C032668
CTD	decreases(expression)			CLU		C032668
CTD	increases(expression)			COMMD3		C032668
CTD	increases(expression)			CORO1C		C032668
CTD	increases(expression)			CSF2		C032668
CTD	increases(expression)			CTGF		C032668
CTD	increases(expression)			CTH		C032668
CTD	increases(expression)			CXCL1		C032668
CTD	increases(expression)			CXCL10		C032668
CTD	increases(expression)			CXCL11		C032668
CTD	decreases(expression)			CXCL13		C032668
CTD	increases(expression)			CXCL2		C032668
CTD	increases(expression)			CXCL3		C032668
CTD	increases(expression)			CXCL5		C032668
CTD	decreases(expression)			CXCL6		C032668
CTD	decreases(expression)			CXCL8		C032668
CTD	increases(expression)			CXCL8		C032668
CTD	increases(secretion)			CXCL8		C032668
CTD	decreases(reaction)			CXCL8		C032668
CTD	increases(expression)			CXCL8		C032668
CTD	decreases(reaction)			CXCL8		C032668
CTD	increases(expression)			CXCL8		C032668
CTD	decreases(expression)			CXCR2		C032668
CTD	decreases(reaction)			CYP1A1		C032668
CTD	increases(expression)			CYP1A1		C032668
CTD	decreases(reaction)			CYP1A1		C032668
CTD	increases(activity)			CYP1A1		C032668
CTD	increases(degradation)			CYP1A1		C032668
CTD	affects(response to substance)			CYP1A1		C032668
CTD	decreases(response to substance)			CYP1A1		C032668
CTD	increases(expression)			CYP1A1		C032668
CTD	decreases(reaction)			CYP1A2		C032668
CTD	increases(activity)			CYP1A2		C032668
CTD	affects(reaction)			CYP1A2		C032668
CTD	increases(mutagenesis)			CYP1A2		C032668
CTD	affects(response to substance)			CYP1A2		C032668
CTD	increases(expression)			CYP1B1		C032668
CTD	increases(metabolic processing)			CYP1B1		C032668
CTD	decreases(expression)			CYP21A2		C032668
CTD	increases(expression)			DDIT3		C032668
CTD	increases(expression)			DKK1		C032668
CTD	increases(expression)			DLC1		C032668
CTD	increases(expression)			DMTF1		C032668
CTD	increases(expression)			DNER		C032668
CTD	increases(expression)			DUSP10		C032668
CTD	increases(expression)			DUSP6		C032668
CTD	increases(expression)			EGR1		C032668
CTD	increases(expression)			EHHADH		C032668
CTD	increases(expression)			EIF4EBP1		C032668
CTD	increases(expression)			EREG		C032668
CTD	increases(expression)			ESM1		C032668
CTD	increases(expression)			ETV5		C032668
CTD	increases(expression)			EVI2A		C032668
CTD	increases(expression)			EXOC5		C032668
CTD	increases(expression)			F3		C032668
CTD	increases(expression)			FGF5		C032668
CTD	increases(expression)			FOS		C032668
CTD	increases(expression)			G0S2		C032668
CTD	increases(expression)			GARS		C032668
CTD	decreases(expression)			GAS1		C032668
CTD	decreases(expression)			GBP2		C032668
CTD	increases(expression)			GDAP1		C032668
CTD	increases(expression)			GLIPR1		C032668
CTD	increases(expression)			GOLGA4		C032668
CTD	increases(expression)			GPT2		C032668
CTD	increases(expression)			GREM1		C032668
CTD	decreases(expression)			GSDMC		C032668
CTD	decreases(expression)			HABP2		C032668
CTD	increases(expression)			HBEGF		C032668
CTD	increases(expression)			HIF1A		C032668
CTD	increases(expression)			HMGA2		C032668
CTD	affects(reaction)			HPRT1		C032668
CTD	increases(mutagenesis)			HPRT1		C032668
CTD	increases(expression)			HSPA5		C032668
CTD	decreases(reaction)			HSPA5		C032668
CTD	increases(expression)			IARS		C032668
CTD	increases(expression)			ICAM1		C032668
CTD	decreases(expression)			IFITM1		C032668
CTD	decreases(expression)			IFNA2		C032668
CTD	increases(expression)			IFRD1		C032668
CTD	decreases(expression)			IL10RB		C032668
CTD	increases(expression)			IL1A		C032668
CTD	increases(secretion)			IL1B		C032668
CTD	decreases(expression)			IL36RN		C032668
CTD	decreases(expression)			IL37		C032668
CTD	increases(expression)			IL6		C032668
CTD	increases(expression)			INA		C032668
CTD	increases(expression)			INHBB		C032668
CTD	increases(expression)			INPP4B		C032668
CTD	increases(expression)			IPO7		C032668
CTD	increases(expression)			IRF1		C032668
CTD	decreases(expression)			ITGB4		C032668
CTD	increases(expression)			JUN		C032668
CTD	increases(expression)			KCTD15		C032668
CTD	increases(expression)			KIAA1429		C032668
CTD	increases(expression)			KRT34		C032668
CTD	increases(expression)			LCOR		C032668
CTD	increases(expression)			LIG4		C032668
CTD	increases(expression)			LMAN1		C032668
CTD	decreases(expression)			LRRC17		C032668
CTD	decreases(expression)			LTA		C032668
CTD	increases(expression)			LTB		C032668
CTD	increases(expression)			LURAP1L		C032668
CTD	increases(expression)			MAK16		C032668
CTD	increases(expression)			MAPK6		C032668
CTD	increases(expression)			MARS		C032668
CTD	increases(expression)			MDM2		C032668
CTD	increases(expression)			MDM2		C032668
CTD	increases(response to substance)			MDM2		C032668
CTD	decreases(response to substance)			MDM2		C032668
CTD	affects(reaction)			MDM2		C032668
CTD	decreases(expression)			METTL7A		C032668
CTD	increases(expression)			MINA		C032668
CTD	increases(expression)			MLPH		C032668
CTD	increases(expression)			MOB4		C032668
CTD	increases(expression)			MOCOS		C032668
CTD	increases(expression)			MOSPD1		C032668
CTD	increases(expression)			MTHFD1L		C032668
CTD	increases(expression)			MTMR2		C032668
CTD	increases(activity)			NFKB1		C032668
CTD	increases(expression)			NFKB1		C032668
CTD	decreases(reaction)			NFKB1		C032668
CTD	decreases(reaction)			NFKBIA		C032668
CTD	increases(activity)			NFKBIA		C032668
CTD	increases(expression)			NFKBIA		C032668
CTD	increases(expression)			NOC3L		C032668
CTD	increases(expression)			NRG1		C032668
CTD	increases(expression)			NT5E		C032668
CTD	decreases(expression)			NTN3		C032668
CTD	decreases(expression)			OAS1		C032668
CTD	increases(expression)			OASL		C032668
CTD	increases(expression)			OSBPL6		C032668
CTD	increases(expression)			OXR1		C032668
CTD	decreases(expression)			PCDHB5		C032668
CTD	increases(expression)			PCK2		C032668
CTD	decreases(expression)			PDGFRB		C032668
CTD	decreases(expression)			PDGFRL		C032668
CTD	decreases(expression)			PDPN		C032668
CTD	increases(expression)			PICALM		C032668
CTD	increases(expression)			PIK3C2A		C032668
CTD	decreases(expression)			PIR		C032668
CTD	decreases(expression)			PLEKHB1		C032668
CTD	increases(expression)			POLA1		C032668
CTD	decreases(expression)			POLR2E		C032668
CTD	increases(expression)			PRKAA1		C032668
CTD	increases(expression)			PRKAR1A		C032668
CTD	increases(expression)			PRKCH		C032668
CTD	increases(expression)			PRMT3		C032668
CTD	increases(expression)			PSAT1		C032668
CTD	decreases(expression)			PSMB9		C032668
CTD	increases(expression)			PSMD5		C032668
CTD	increases(expression)			PSME4		C032668
CTD	increases(expression)			PTCD2		C032668
CTD	increases(expression)			PTHLH		C032668
CTD	decreases(expression)			PTN		C032668
CTD	increases(expression)			PTPRB		C032668
CTD	decreases(expression)			RAB20		C032668
CTD	decreases(expression)			RAB26		C032668
CTD	decreases(expression)			RAB34		C032668
CTD	decreases(expression)			RAMP1		C032668
CTD	increases(expression)			RANBP6		C032668
CTD	decreases(expression)			RARRES3		C032668
CTD	increases(expression)			RASA2		C032668
CTD	increases(activity)			RELA		C032668
CTD	decreases(reaction)			RELA		C032668
CTD	increases(expression)			RND3		C032668
CTD	increases(expression)			RSC1A1		C032668
CTD	increases(expression)			SACS		C032668
CTD	decreases(expression)			SCNN1A		C032668
CTD	decreases(expression)			SECTM1		C032668
CTD	increases(expression)			SELE		C032668
CTD	increases(expression)			SERPINB8		C032668
CTD	increases(expression)			SERPINE1		C032668
CTD	increases(expression)			SH3KBP1		C032668
CTD	increases(expression)			SH3RF1		C032668
CTD	increases(expression)			SLMAP		C032668
CTD	increases(expression)			SMURF2		C032668
CTD	decreases(expression)			SNCA		C032668
CTD	increases(expression)			SNX14		C032668
CTD	decreases(expression)			SOX21		C032668
CTD	decreases(expression)			SPP1		C032668
CTD	increases(expression)			STC2		C032668
CTD	decreases(expression)			TACSTD2		C032668
CTD	increases(expression)			TAGLN		C032668
CTD	increases(expression)			TARS		C032668
CTD	increases(expression)			TAX1BP1		C032668
CTD	increases(expression)			THBD		C032668
CTD	affects(binding)			TLR3		C032668
CTD	affects(response to substance)			TLR3		C032668
CTD	increases(expression)			TMPO		C032668
CTD	increases(expression)			TNF		C032668
CTD	increases(secretion)			TNF		C032668
CTD	increases(expression)			TNPO1		C032668
CTD	increases(expression)			TOP1		C032668
CTD	increases(expression)			TOP2B		C032668
CTD	increases(expression)			TP53		C032668
CTD	increases(expression)			TP53		C032668
CTD	decreases(response to substance)			TP53		C032668
CTD	affects(binding)			TP53		C032668
CTD	increases(activity)			TP53		C032668
CTD	affects(response to substance)			TP53		C032668
CTD	increases(response to substance)			TP53		C032668
CTD	affects(reaction)			TP53		C032668
CTD	increases(expression)			TP53		C032668
CTD	affects(response to substance)			TP53		C032668
CTD	increases(expression)			TRIB3		C032668
CTD	increases(expression)			TRIM23		C032668
CTD	increases(expression)			TRPM7		C032668
CTD	increases(expression)			TRUB1		C032668
CTD	increases(expression)			UBASH3B		C032668
CTD	increases(expression)			USP15		C032668
CTD	increases(expression)			VCAN		C032668
CTD	increases(expression)			WARS		C032668
CTD	increases(expression)			WDFY3		C032668
CTD	increases(expression)			WNT2		C032668
CTD	decreases(expression)			XCR1		C032668
CTD	increases(expression)			XPOT		C032668
CTD	increases(expression)			ZDHHC11		C032668
CTD	increases(expression)			ZEB1		C032668
CTD	increases(expression)			ZFP62		C032668
PubChem	Ratio Potency (uM)	uM	1.672	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	2.753	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	1.788	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	4.328	NFE2L2	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :

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