Tan Lab | DSigDB

Gene Set: D4 : CTD - hydroquinone

Collection

D4 : CTD

Chemical Name

hydroquinone ( From PubChem : HYDROQUINONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Not	Not	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
110.111 g/mol	2	2	1.0978	True

Structure

InChI

InChI=1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H

InChIKey

QIGBRXMKCJKVMJ-UHFFFAOYSA-N

Links

Gene (172 / 318)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			AEN		C031927
CTD	increases(expression)			ALDH2		C031927
CTD	affects(expression)			ARHGDIA		C031927
CTD	increases(expression)			ATF4		C031927
CTD	decreases(expression)			BAD		C031927
CTD	increases(expression)			BBC3		C031927
CTD	increases(expression)			BIRC3		C031927
CTD	decreases(expression)			BNIP3		C031927
CTD	decreases(expression)			BORA		C031927
CTD	increases(expression)			BTG2		C031927
CTD	decreases(reaction)			CASP3		C031927
CTD	increases(activity)			CASP3		C031927
CTD	decreases(activity)			CASP3		C031927
CTD	decreases(expression)			CASP3		C031927
CTD	increases(activity)			CASP3		C031927
CTD	increases(cleavage)			CASP3		C031927
CTD	decreases(expression)			CASP6		C031927
CTD	decreases(activity)			CASP7		C031927
CTD	increases(cleavage)			CASP7		C031927
CTD	decreases(reaction)			CASP7		C031927
CTD	affects(reaction)			CASP8		C031927
CTD	increases(cleavage)			CASP8		C031927
CTD	decreases(expression)			CASP9		C031927
CTD	increases(activity)			CASP9		C031927
CTD	increases(cleavage)			CASP9		C031927
CTD	decreases(response to substance)			CAT		C031927
CTD	increases(expression)			CCL11		C031927
CTD	decreases(secretion)			CCL2		C031927
CTD	increases(expression)			CCL2		C031927
CTD	increases(secretion)			CCL2		C031927
CTD	increases(expression)			CCL3		C031927
CTD	increases(expression)			CCL4		C031927
CTD	increases(expression)			CCL5		C031927
CTD	increases(expression)			CCNE2		C031927
CTD	decreases(expression)			CCNF		C031927
CTD	increases(expression)			CD86		C031927
CTD	decreases(expression)			CDCA2		C031927
CTD	increases(expression)			CDKN1A		C031927
CTD	decreases(expression)			CENPA		C031927
CTD	increases(expression)			COL1A1		C031927
CTD	decreases(reaction)			COL1A1		C031927
CTD	affects(cotreatment)			COL1A1		C031927
CTD	decreases(expression)			COL4A1		C031927
CTD	increases(expression)			COL4A1		C031927
CTD	decreases(reaction)			COL4A1		C031927
CTD	affects(cotreatment)			COL4A1		C031927
CTD	affects(cotreatment)			CSF1R		C031927
CTD	increases(abundance)			CSF1R		C031927
CTD	increases(reaction)			CSF1R		C031927
CTD	affects(cotreatment)			CSF2		C031927
CTD	increases(activity)			CSF2		C031927
CTD	increases(phosphorylation)			CSF2		C031927
CTD	decreases(expression)			CXCL12		C031927
CTD	decreases(secretion)			CXCL8		C031927
CTD	increases(expression)			CXCL8		C031927
CTD	increases(secretion)			CXCL8		C031927
CTD	affects(localization)			CYCS		C031927
CTD	affects(response to substance)			CYP1A1		C031927
CTD	increases(expression)			CYP1A1		C031927
CTD	increases(expression)			CYP1B1		C031927
CTD	increases(chemical synthesis)			CYP2D6		C031927
CTD	increases(metabolic processing)			CYP2D6		C031927
CTD	affects(chemical synthesis)			CYP2E1		C031927
CTD	affects(metabolic processing)			CYP2E1		C031927
CTD	increases(chemical synthesis)			CYP3A4		C031927
CTD	increases(metabolic processing)			CYP3A4		C031927
CTD	increases(chemical synthesis)			CYP3A5		C031927
CTD	increases(metabolic processing)			CYP3A5		C031927
CTD	affects(expression)			CYR61		C031927
CTD	decreases(expression)			DAP		C031927
CTD	increases(expression)			DDIT3		C031927
CTD	increases(expression)			DDIT4		C031927
CTD	affects(expression)			DKK1		C031927
CTD	increases(expression)			DNAJA1		C031927
CTD	increases(expression)			DNAJB1		C031927
CTD	decreases(expression)			DNMT1		C031927
CTD	decreases(expression)			DNMT3A		C031927
CTD	decreases(expression)			DNMT3B		C031927
CTD	increases(expression)			ELF3		C031927
CTD	decreases(expression)			FADD		C031927
CTD	decreases(expression)			FAM83D		C031927
CTD	decreases(expression)			FBXO5		C031927
CTD	affects(expression)			FN1		C031927
CTD	decreases(expression)			FOS		C031927
CTD	increases(expression)			FTH1		C031927
CTD	increases(expression)			GADD45A		C031927
CTD	decreases(reaction)			GATA1		C031927
CTD	increases(expression)			GATA1		C031927
CTD	decreases(reaction)			GATA1		C031927
CTD	increases(expression)			GATA1		C031927
CTD	decreases(expression)			GATA1		C031927
CTD	decreases(expression)			GATA2		C031927
CTD	increases(reaction)			GATA2		C031927
CTD	increases(expression)			GCLM		C031927
CTD	increases(expression)			GDF15		C031927
CTD	affects(expression)			GRB2		C031927
CTD	increases(expression)			GSS		C031927
CTD	affects(reaction)			GSS		C031927
CTD	affects(response to substance)			GSTM1		C031927
CTD	decreases(expression)			GYPA		C031927
CTD	affects(localization)			H2AFX		C031927
CTD	increases(expression)			H2AFX		C031927
CTD	increases(phosphorylation)			H2AFX		C031927
CTD	increases(expression)			H2AFX		C031927
CTD	increases(response to substance)			H2AFX		C031927
CTD	increases(reaction)			H2AFX		C031927
CTD	affects(reaction)			H2AFX		C031927
CTD	increases(expression)			H2AFX		C031927
CTD	decreases(reaction)			HBB		C031927
CTD	increases(expression)			HBB		C031927
CTD	decreases(reaction)			HBB		C031927
CTD	increases(expression)			HBB		C031927
CTD	decreases(expression)			HIST1H1B		C031927
CTD	decreases(expression)			HIST1H1D		C031927
CTD	decreases(expression)			HIST1H1E		C031927
CTD	decreases(expression)			HIST1H2AH		C031927
CTD	decreases(expression)			HIST1H2AI		C031927
CTD	decreases(expression)			HIST1H2AJ		C031927
CTD	decreases(expression)			HIST1H3B		C031927
CTD	decreases(expression)			HIST1H3C		C031927
CTD	decreases(expression)			HIST1H4A		C031927
CTD	decreases(expression)			HIST1H4B		C031927
CTD	decreases(expression)			HIST1H4C		C031927
CTD	decreases(expression)			HIST1H4E		C031927
CTD	decreases(expression)			HIST1H4F		C031927
CTD	decreases(expression)			HIST1H4H		C031927
CTD	decreases(expression)			HIST1H4K		C031927
CTD	decreases(expression)			HIST2H2AA3		C031927
CTD	decreases(expression)			HIST2H2AB		C031927
CTD	decreases(expression)			HIST2H2AC		C031927
CTD	decreases(expression)			HIST2H4A		C031927
CTD	decreases(expression)			HJURP		C031927
CTD	decreases(reaction)			HMBS		C031927
CTD	increases(expression)			HMBS		C031927
CTD	decreases(reaction)			HMBS		C031927
CTD	increases(expression)			HMBS		C031927
CTD	decreases(expression)			HMGB2		C031927
CTD	increases(expression)			HMOX1		C031927
CTD	affects(reaction)			HMOX1		C031927
CTD	increases(expression)			HSPA2		C031927
CTD	decreases(expression)			HYLS1		C031927
CTD	affects(cotreatment)			IL10		C031927
CTD	decreases(reaction)			IL10		C031927
CTD	increases(expression)			IL10		C031927
CTD	decreases(reaction)			IL2		C031927
CTD	increases(expression)			IL2		C031927
CTD	decreases(secretion)			IL6		C031927
CTD	decreases(expression)			ITGB1		C031927
CTD	decreases(expression)			ITGB2		C031927
CTD	decreases(expression)			JAG1		C031927
CTD	decreases(expression)			KIF18A		C031927
CTD	increases(expression)			KITLG		C031927
CTD	increases(expression)			LAMA4		C031927
CTD	decreases(reaction)			LAMA4		C031927
CTD	affects(cotreatment)			LAMA4		C031927
CTD	affects(expression)			LASP1		C031927
CTD	decreases(reaction)			LECT1		C031927
CTD	increases(expression)			LECT1		C031927
CTD	increases(secretion)			LECT1		C031927
CTD	increases(response to substance)			LECT1		C031927
CTD	affects(expression)			LMNA		C031927
CTD	decreases(reaction)			MAPK1		C031927
CTD	increases(activity)			MAPK1		C031927
CTD	increases(phosphorylation)			MAPK1		C031927
CTD	affects(cotreatment)			MAPK1		C031927
CTD	decreases(reaction)			MAPK3		C031927
CTD	increases(activity)			MAPK3		C031927
CTD	increases(phosphorylation)			MAPK3		C031927
CTD	affects(cotreatment)			MAPK3		C031927
CTD	decreases(expression)			MBD2		C031927
CTD	increases(expression)			MGST1		C031927
CTD	affects(cotreatment)			MMP14		C031927
CTD	decreases(activity)			MMP14		C031927
CTD	decreases(reaction)			MMP14		C031927
CTD	increases(expression)			MMP14		C031927
CTD	affects(expression)			MMP15		C031927
CTD	decreases(activity)			MMP2		C031927
CTD	affects(cotreatment)			MMP2		C031927
CTD	decreases(activity)			MMP2		C031927
CTD	decreases(reaction)			MMP2		C031927
CTD	affects(expression)			MMP3		C031927
CTD	decreases(reaction)			MMP9		C031927
CTD	increases(expression)			MMP9		C031927
CTD	increases(secretion)			MMP9		C031927
CTD	increases(reaction)			MMP9		C031927
CTD	increases(expression)			MPL		C031927
CTD	increases(reaction)			MPL		C031927
CTD	decreases(methylation)			MPL		C031927
CTD	affects(reaction)			MPO		C031927
CTD	increases(cleavage)			MPO		C031927
CTD	affects(cotreatment)			MPO		C031927
CTD	decreases(activity)			MPO		C031927
CTD	increases(reaction)			MPO		C031927
CTD	increases(chemical synthesis)			MPO		C031927
CTD	increases(hydroxylation)			MPO		C031927
CTD	increases(oxidation)			MPO		C031927
CTD	decreases(reaction)			MYC		C031927
CTD	increases(expression)			MYC		C031927
CTD	decreases(reaction)			NFE2		C031927
CTD	increases(expression)			NFE2		C031927
CTD	decreases(reaction)			NFE2L2		C031927
CTD	increases(activity)			NFE2L2		C031927
CTD	affects(localization)			NFE2L2		C031927
CTD	increases(expression)			NFE2L2		C031927
CTD	affects(reaction)			NFE2L2		C031927
CTD	increases(activity)			NQO1		C031927
CTD	increases(expression)			NQO1		C031927
CTD	increases(expression)			NQO1		C031927
CTD	increases(expression)			NQO1		C031927
CTD	decreases(reaction)			NQO1		C031927
CTD	increases(expression)			NQO1		C031927
CTD	increases(response to substance)			NQO1		C031927
CTD	decreases(response to substance)			NQO1		C031927
CTD	affects(expression)			PA2G4		C031927
CTD	increases(cleavage)			PARP1		C031927
CTD	decreases(reaction)			PARP1		C031927
CTD	affects(expression)			PGLS		C031927
CTD	increases(response to substance)			POLH		C031927
CTD	increases(expression)			POLH		C031927
CTD	increases(expression)			PPM1D		C031927
CTD	increases(expression)			PRDX1		C031927
CTD	increases(expression)			PRKDC		C031927
CTD	decreases(expression)			PSRC1		C031927
CTD	increases(expression)			RECQL4		C031927
CTD	affects(localization)			RELA		C031927
CTD	decreases(reaction)			RELA		C031927
CTD	increases(expression)			RELA		C031927
CTD	increases(expression)			RUNX2		C031927
CTD	increases(expression)			SESN1		C031927
CTD	increases(expression)			SESN2		C031927
CTD	decreases(activity)			SOD1		C031927
CTD	decreases(expression)			SOD1		C031927
CTD	decreases(activity)			SOD2		C031927
CTD	decreases(expression)			SOD2		C031927
CTD	increases(phosphorylation)			SPI1		C031927
CTD	increases(expression)			STC2		C031927
CTD	affects(expression)			TALDO1		C031927
CTD	affects(expression)			TARDBP		C031927
CTD	decreases(reaction)			TFRC		C031927
CTD	increases(expression)			TFRC		C031927
CTD	decreases(expression)			TFRC		C031927
CTD	increases(reaction)			TFRC		C031927
CTD	affects(cotreatment)			TIMP2		C031927
CTD	decreases(activity)			TIMP2		C031927
CTD	decreases(reaction)			TIMP2		C031927
CTD	increases(expression)			TIMP2		C031927
CTD	increases(expression)			TIPARP		C031927
CTD	decreases(reaction)			TNF		C031927
CTD	increases(expression)			TNF		C031927
CTD	increases(secretion)			TNF		C031927
CTD	affects(cotreatment)			TNF		C031927
CTD	decreases(reaction)			TNF		C031927
CTD	increases(expression)			TNF		C031927
CTD	increases(reaction)			TNF		C031927
CTD	decreases(activity)			TNF		C031927
CTD	increases(secretion)			TNF		C031927
CTD	decreases(expression)			TNFRSF10B		C031927
CTD	decreases(expression)			TNFRSF10D		C031927
CTD	decreases(expression)			TNFRSF25		C031927
CTD	increases(expression)			TNFRSF9		C031927
CTD	decreases(expression)			TNFSF12		C031927
CTD	affects(activity)			TOP2A		C031927
CTD	decreases(activity)			TOP2A		C031927
CTD	affects(cotreatment)			TOP2A		C031927
CTD	decreases(activity)			TOP2A		C031927
CTD	increases(reaction)			TOP2A		C031927
CTD	increases(expression)			TP53		C031927
CTD	affects(reaction)			TP53		C031927
CTD	increases(acetylation)			TP53		C031927
CTD	increases(expression)			TP53INP1		C031927
CTD	increases(expression)			TRADD		C031927
CTD	decreases(expression)			TRAF4		C031927
CTD	decreases(expression)			TRIM59		C031927
CTD	increases(activity)			TRPA1		C031927
CTD	increases(expression)			TXN		C031927
CTD	increases(expression)			TXNRD1		C031927
CTD	increases(expression)			WNT5A		C031927
CTD	increases(expression)			WRN		C031927
CTD	increases(reaction)			WRN		C031927
CTD	increases(response to substance)			WRN		C031927
CTD	affects(reaction)			WRN		C031927
CTD	increases(acetylation)			WRN		C031927
CTD	increases(expression)			WRN		C031927
CTD	decreases(reaction)			WRN		C031927
CTD	increases(cleavage)			WRN		C031927
CTD	decreases(response to substance)			WRN		C031927
PubChem	AhR Potency (uM)	uM	10.068	AHR	-	GI(Protien) :
PubChem	Potency	uM	66.824	CXCL8	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	60.758	CYP19A1	-	GI(Protien) :
PubChem	Potency	uM	1.778	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	5.973	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	2.512	GLS	-	GI(Protien) :
PubChem	None	uM		GSTO1	-	GI(Protien) :
PubChem	Potency	uM	1.995	HIF1A	-	GI(Protien) :
PubChem	Potency	uM	5.623	HPGD	-	GI(Protien) :
PubChem	Potency	uM	7.943	HPGD	-	GI(Protien) :
PubChem	Potency	uM	10.000	HPGD	-	GI(Protien) :
PubChem	None	uM		HTT	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	1.369	NFE2L2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	1.413	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	2.113	NFE2L2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	2.282	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	18.356	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	10.000	NFKB1	-	GI(Protien) :
PubChem	None	uM		PTGER2	-	GI(Protien) :
PubChem	Potency	uM	20.596	TDP1	-	GI(Protien) :
PubChem	Potency	uM	12.589	THPO	-	GI(Protien) :
ChEMBL	Potency	nM	1778.300	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	5972.800	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	1995.300	HIF1A	-	Target : CHEMBL4261
ChEMBL	Potency	nM	10000.000	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	5623.400	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	7943.300	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	1258.900	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	1258.900	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	398.100	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	10000.000	NFKB1	-	Target : CHEMBL3251
ChEMBL	Potency	nM	12589.300	THPO	-	Target : CHEMBL1293256

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