Tan Lab | DSigDB

Gene Set: D4 : CTD - phenothiazine

Collection

D4 : CTD

Chemical Name

phenothiazine ( From PubChem : PHENOTHIAZINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
199.272 g/mol	1	1	4.0328	True

Structure

InChI

InChI=1S/C12H9NS/c1-3-7-11-9(5-1)13-10-6-2-4-8-12(10)14-11/h1-8,13H

InChIKey

Links

Gene (18 / 35)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(localization)			AR		C031637
CTD	affects(binding)			AR		C031637
CTD	decreases(activity)			AR		C031637
CTD	affects(reaction)			KLK3		C031637
CTD	increases(expression)			KLK3		C031637
PubChem	Potency	uM	14.125	ALOX12	-	GI(Protien) :
PubChem	Potency	uM	6.310	ALOX15	-	GI(Protien) :
PubChem	Potency	uM	12.589	BAZ2B	-	GI(Protien) :
PubChem	None	uM		DRD2	-	GI(Protien) :
PubChem	None	uM		DRD2	-	GI(Protien) :
PubChem	Potency	uM	12.589	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	31.623	EHMT2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	26.603	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	34.376	ESR1	-	GI(Protien) :
PubChem	Potency	uM	17.783	GAA	-	GI(Protien) :
PubChem	None	uM		ITGA4	-	GI(Protien) :
PubChem	Potency	uM	54.483	NFE2L2	-	GI(Protien) :
PubChem	IC50	uM	0.349	NOX1	-	GI(Protien) :
PubChem	IC50	uM	0.369	NOX1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	44.668	NR1I2	-	GI(Protien) :
PubChem	Potency	uM	39.811	PPARG	-	GI(Protien) :
PubChem	IC50	uM	18.500	RACGAP1	-	GI(Protien) :
PubChem	Potency	uM	5.309	TDP1	-	GI(Protien) :
PubChem	Potency	uM	5.309	TDP1	-	GI(Protien) :
PubChem	Potency	uM	34.376	TDP1	-	GI(Protien) :
ChEMBL	Potency	nM	14125.400	ALOX12	-	Target : CHEMBL3687
ChEMBL	Potency	nM	6309.600	ALOX15	-	Target : CHEMBL2903
ChEMBL	Potency	nM	5011.900	ALOX15B	-	Target : CHEMBL2457
ChEMBL	Potency	nM	12589.300	BAZ2B	-	Target : CHEMBL1741220
ChEMBL	Potency	nM	12589.300	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	31622.800	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	17782.800	GAA	-	Target : CHEMBL2608
ChEMBL	Potency	nM	15848.900	MAPT	-	Target : CHEMBL1293224
ChEMBL	IC50	nM	368.700	NOX1	-	Target : CHEMBL1287628
ChEMBL	IC50	nM	349.000	NOX1	-	Target : CHEMBL1287628

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