Tan Lab | DSigDB

Gene Set: D4 : CTD - biochanin A

Collection

D4 : CTD

Chemical Name

biochanin A ( From PubChem : BIOCHANIN A )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
284.263 g/mol	2	5	2.8798	True

Structure

InChI

InChI=1S/C16H12O5/c1-20-11-4-2-9(3-5-11)12-8-21-14-7-10(17)6-13(18)15(14)16(12)19/h2-8,17-18H,1H3

InChIKey

WUADCCWRTIWANL-UHFFFAOYSA-N

Links

Gene (83 / 139)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(activity)			ABCC1		C004541
CTD	affects(export)			ABCC2		C004541
CTD	decreases(reaction)			ABCC2		C004541
CTD	decreases(expression)			AGRN		C004541
CTD	affects(binding)			AHR		C004541
CTD	decreases(reaction)			AHR		C004541
CTD	increases(reaction)			AHR		C004541
CTD	decreases(expression)			ALDH7A1		C004541
CTD	increases(expression)			ARID5B		C004541
CTD	decreases(expression)			BCL2		C004541
CTD	decreases(expression)			BCL2L1		C004541
CTD	increases(expression)			BRE		C004541
CTD	increases(activity)			CASP3		C004541
CTD	decreases(expression)			CDH2		C004541
CTD	decreases(expression)			CDKN1A		C004541
CTD	increases(activity)			CKB		C004541
CTD	affects(binding)			CYP19A1		C004541
CTD	decreases(activity)			CYP19A1		C004541
CTD	decreases(activity)			CYP19A1		C004541
CTD	decreases(expression)			CYP19A1		C004541
CTD	affects(cotreatment)			CYP19A1		C004541
CTD	affects(binding)			CYP1A1		C004541
CTD	decreases(reaction)			CYP1A1		C004541
CTD	increases(reaction)			CYP1A1		C004541
CTD	increases(activity)			CYP1A1		C004541
CTD	increases(expression)			CYP1A1		C004541
CTD	decreases(methylation)			CYP1A1		C004541
CTD	increases(hydroxylation)			CYP1A1		C004541
CTD	increases(metabolic processing)			CYP1A2		C004541
CTD	decreases(methylation)			CYP1B1		C004541
CTD	affects(activity)			CYP27B1		C004541
CTD	affects(expression)			CYP27B1		C004541
CTD	increases(activity)			CYP27B1		C004541
CTD	increases(expression)			CYP27B1		C004541
CTD	decreases(expression)			DERA		C004541
CTD	decreases(expression)			EIF5		C004541
CTD	decreases(expression)			ENPP5		C004541
CTD	decreases(expression)			EPS15		C004541
CTD	affects(binding)			ESR1		C004541
CTD	increases(activity)			ESR1		C004541
CTD	affects(binding)			ESR1		C004541
CTD	affects(binding)			ESR1		C004541
CTD	decreases(reaction)			ESR1		C004541
CTD	affects(binding)			ESR2		C004541
CTD	increases(activity)			ESR2		C004541
CTD	affects(binding)			ESR2		C004541
CTD	affects(binding)			ESR2		C004541
CTD	decreases(reaction)			ESR2		C004541
CTD	affects(binding)			ESRRA		C004541
CTD	increases(activity)			ESRRA		C004541
CTD	increases(reaction)			ESRRA		C004541
CTD	affects(binding)			ESRRB		C004541
CTD	increases(activity)			ESRRB		C004541
CTD	increases(reaction)			ESRRB		C004541
CTD	affects(binding)			ESRRG		C004541
CTD	increases(reaction)			ESRRG		C004541
CTD	increases(expression)			FBL		C004541
CTD	decreases(expression)			FOLR1		C004541
CTD	decreases(expression)			GM2A		C004541
CTD	decreases(expression)			GNAI3		C004541
CTD	decreases(expression)			GPX1		C004541
CTD	decreases(expression)			LDLRAD4		C004541
CTD	increases(expression)			LXN		C004541
CTD	decreases(expression)			MMP14		C004541
CTD	decreases(activity)			MMP2		C004541
CTD	decreases(activity)			MMP9		C004541
CTD	increases(expression)			MT2A		C004541
CTD	decreases(expression)			NDUFA5		C004541
CTD	decreases(expression)			NONO		C004541
CTD	increases(cleavage)			PARP1		C004541
CTD	decreases(expression)			PFDN5		C004541
CTD	affects(binding)			PGR		C004541
CTD	decreases(reaction)			PGR		C004541
CTD	increases(expression)			PGR		C004541
CTD	decreases(expression)			PLAUR		C004541
CTD	affects(binding)			PNRC1		C004541
CTD	increases(reaction)			PNRC1		C004541
CTD	decreases(expression)			RABL6		C004541
CTD	decreases(expression)			RELA		C004541
CTD	decreases(expression)			RIF1		C004541
CTD	decreases(expression)			RPUSD3		C004541
CTD	increases(expression)			SH3GL1		C004541
CTD	decreases(expression)			SLC25A3		C004541
CTD	decreases(expression)			SRSF1		C004541
CTD	increases(expression)			SUSD6		C004541
CTD	decreases(expression)			TMEM191A		C004541
CTD	decreases(expression)			TNFRSF21		C004541
CTD	increases(expression)			TUBB		C004541
CTD	decreases(expression)			UBE2D2		C004541
CTD	increases(glucuronidation)			UGT1A1		C004541
CTD	increases(glucuronidation)			UGT1A10		C004541
CTD	increases(glucuronidation)			UGT1A7		C004541
CTD	increases(glucuronidation)			UGT1A8		C004541
CTD	increases(glucuronidation)			UGT1A9		C004541
CTD	decreases(expression)			WDR74		C004541
CTD	decreases(expression)			WWC2		C004541
PubChem	AhR Potency (uM)	uM	5.448	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	8.377	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	9.688	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	9.767	AHR	-	GI(Protien) :
PubChem	Potency	uM	9.960	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	23.109	ATAD5	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	7.943	CYP2C19	-	GI(Protien) :
PubChem	Potency	uM	31.623	CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	19.953	CYP3A4	-	GI(Protien) :
PubChem	None	uM		DRD5	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.436	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.864	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	6.973	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	13.395	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	13.804	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	14.905	ESR1	-	GI(Protien) :
PubChem	None	uM		FGF22	-	GI(Protien) :
PubChem	Potency	uM	15.849	MAPK1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	8.635	NFE2L2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	17.369	NFE2L2	-	GI(Protien) :
PubChem	None	uM		NFKB1	-	GI(Protien) :
PubChem	Potency	uM	2.239	NPC1	-	GI(Protien) :
PubChem	None	uM		NR0B1	-	GI(Protien) :
PubChem	None	uM		NR0B1	-	GI(Protien) :
PubChem	None	uM		NR1H4	-	GI(Protien) :
PubChem	None	uM		NR5A1	-	GI(Protien) :
PubChem	None	uM		NR5A1	-	GI(Protien) :
PubChem	None	uM		PPARG	-	GI(Protien) :
PubChem	Potency	uM	2.818	RAB9A	-	GI(Protien) :
PubChem	None	uM		RELA	-	GI(Protien) :
PubChem	Potency	uM	17.783	SMN2	-	GI(Protien) :
PubChem	None	uM		STAT1	-	GI(Protien) :
PubChem	None	uM		STAT1	-	GI(Protien) :
PubChem	None	uM		WEE1	-	GI(Protien) :
ChEMBL	Potency	nM	23109.300	ATAD5	-	Target : CHEMBL1741209
ChEMBL	Potency	nM	7943.300	CYP2C19	-	Target : CHEMBL3622
ChEMBL	Potency	nM	31622.800	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	19952.600	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	15848.900	MAPK1	-	Target : CHEMBL4040
ChEMBL	Potency	nM	2238.700	NPC1	-	Target : CHEMBL1293277
ChEMBL	Potency	nM	2818.400	RAB9A	-	Target : CHEMBL1293294
ChEMBL	Potency	nM	17782.800	SMN1; SMN2	-	Target : CHEMBL1293232

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