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Gene Set: D4 : CTD - coumarin

Collection D4 : CTD
Chemical Name coumarin ( From PubChem : COUMARIN )
FDA NPC WHO Indian Australia China Traditional
Herbal		 Clinical
Trail
NotNotNotApprovedNotNotApprovedNot
Molecular
Weight		 Hydrogen Bond
Donor Count		 Hydrogen Bond
Acceptor Count		 cLogP Lipinski Rule
146.143 g/mol 0 2 1.793 True
Structure
InChI InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
InChIKey ZYGHJZDHTFUPRJ-UHFFFAOYSA-N
Links

Gene (20 / 48)


⊖ Less
Source Type Unit Value Gene PMID Assay Other
CTDincreases(expression)BAX
C030123
CTDdecreases(expression)BCL2
C030123
CTDdecreases(activity)CA1
C030123
CTDdecreases(activity)CA2
C030123
CTDincreases(hydroxylation)CYP2A
C030123
CTDdecreases(hydroxylation)CYP2A13
C030123
CTDincreases(hydroxylation)CYP2A13
C030123
CTDdecreases(reaction)CYP2A6
C030123
CTDincreases(glutathionylation)CYP2A6
C030123
CTDdecreases(activity)CYP2A6
C030123
CTDdecreases(metabolic processing)CYP2A6
C030123
CTDincreases(metabolic processing)CYP2A6
C030123
CTDaffects(metabolic processing)CYP2A6
C030123
CTDaffects(metabolic processing)CYP2A6
C030123
CTDaffects(binding)CYP2A6
C030123
CTDincreases(metabolic processing)CYP2A6
C030123
CTDaffects(metabolic processing)CYP2A6
C030123
CTDincreases(hydroxylation)CYP2A6
C030123
CTDincreases(hydroxylation)CYP2A6
C030123
CTDaffects(abundance)CYP2A6
C030123
CTDincreases(metabolic processing)CYP2A6
C030123
CTDincreases(metabolic processing)CYP2A6
C030123
CTDdecreases(reaction)CYP2A6
C030123
CTDincreases(hydroxylation)CYP2A6
C030123
CTDdecreases(reaction)CYP2A6
C030123
CTDincreases(metabolic processing)CYP2A6
C030123
CTDaffects(metabolic processing)CYP2C9
C030123
CTDaffects(response to substance)CYP2C9
C030123
CTDincreases(response to substance)F9
C030123
CTDaffects(cotreatment)HSD17B1
C030123
CTDdecreases(reaction)HSD17B1
C030123
CTDincreases(reduction)HSD17B1
C030123
CTDdecreases(expression)MGP
C030123
CTDdecreases(activity)PARP1
C030123
CTDdecreases(abundance)PARP1
C030123
CTDdecreases(reaction)PARP1
C030123
CTDdecreases(response to substance)VKORC1
C030123
CTDincreases(response to substance)VKORC1
C030123
CTDincreases(response to substance)VKORC1
C030123
PubChem Potency-Replicate_1uM18.834ESR1-GI(Protien) :
PubChem PotencyuM501.187NFE2L2-GI(Protien) :
PubChem Potency-Replicate_1uM1258.930NR1I2-GI(Protien) :
ChEMBLInhibition-CYP1A2
-Target : CHEMBL3356
ChEMBLInhibition-CYP2C19
-Target : CHEMBL3622
ChEMBLInhibition-CYP2C9
-Target : CHEMBL3397
ChEMBLInhibition-CYP2D6
-Target : CHEMBL289
ChEMBLInhibition-CYP3A4
-Target : CHEMBL340
ChEMBLInhibition-CYP3A4
-Target : CHEMBL340
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