Tan Lab | DSigDB

Gene Set: D4 : CTD - 4-phenylenediamine

Collection

D4 : CTD

Chemical Name

4-phenylenediamine ( From PubChem : P-PHENYLENEDIAMINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
108.141 g/mol	2	2	2.0134	True

Structure

InChI

InChI=1S/C6H8N2/c7-5-1-2-6(8)4-3-5/h1-4H,7-8H2

InChIKey

CBCKQZAAMUWICA-UHFFFAOYSA-N

Links

Gene (54 / 76)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			ABCC3		C029728
CTD	increases(activity)			AKR1C2		C029728
CTD	increases(expression)			AKR1C2		C029728
CTD	increases(expression)			ANXA1		C029728
CTD	increases(expression)			ATF3		C029728
CTD	increases(expression)			CCL3L1		C029728
CTD	increases(expression)			CCL4		C029728
CTD	decreases(expression)			CCR2		C029728
CTD	increases(expression)			CD274		C029728
CTD	increases(expression)			CD86		C029728
CTD	decreases(reaction)			CD86		C029728
CTD	increases(expression)			CD86		C029728
CTD	increases(expression)			CDKN1A		C029728
CTD	increases(expression)			CREM		C029728
CTD	increases(expression)			CXCL1		C029728
CTD	increases(expression)			CXCL8		C029728
CTD	increases(expression)			CXCL8		C029728
CTD	increases(secretion)			CXCL8		C029728
CTD	affects(reaction)			CXCL8		C029728
CTD	affects(reaction)			CXCL8		C029728
CTD	increases(secretion)			CXCL8		C029728
CTD	increases(expression)			CYTIP		C029728
CTD	increases(expression)			DNAJB4		C029728
CTD	increases(expression)			DUSP1		C029728
CTD	increases(expression)			FTH1		C029728
CTD	increases(expression)			GABARAPL3		C029728
CTD	increases(expression)			GCLM		C029728
CTD	increases(metabolic processing)			GSTP1		C029728
CTD	increases(expression)			HIF1A		C029728
CTD	increases(expression)			HMOX1		C029728
CTD	increases(expression)			HSPA6		C029728
CTD	increases(expression)			HSPH1		C029728
CTD	increases(expression)			HTATIP2		C029728
CTD	increases(expression)			ME1		C029728
CTD	increases(expression)			MT1H		C029728
CTD	increases(expression)			MT2A		C029728
CTD	decreases(activity)			NAT1		C029728
CTD	decreases(expression)			NAT1		C029728
CTD	increases(acetylation)			NAT1		C029728
CTD	affects(response to substance)			NAT2		C029728
CTD	increases(expression)			NFE2L2		C029728
CTD	increases(expression)			NINJ1		C029728
CTD	increases(expression)			NQO1		C029728
CTD	increases(expression)			PGD		C029728
CTD	increases(expression)			PIR		C029728
CTD	increases(expression)			PLIN2		C029728
CTD	increases(expression)			PMAIP1		C029728
CTD	increases(expression)			PPARG		C029728
CTD	increases(expression)			PTGS1		C029728
CTD	increases(expression)			PTGS2		C029728
CTD	increases(expression)			RGS1		C029728
CTD	increases(expression)			RIT1		C029728
CTD	increases(expression)			S100P		C029728
CTD	increases(expression)			SI		C029728
CTD	decreases(expression)			SLAMF1		C029728
CTD	increases(expression)			SLC2A3		C029728
CTD	increases(expression)			SPTA1		C029728
CTD	affects(response to substance)			TNF		C029728
CTD	increases(expression)			TNFAIP3		C029728
CTD	increases(expression)			TNFAIP6		C029728
CTD	increases(expression)			VEGFA		C029728
PubChem	Potency-Replicate_1	uM	19.331	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	22.630	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	25.289	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	29.849	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	29.849	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	48.755	AHR	-	GI(Protien) :
PubChem	Potency	uM	12.589	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	14.125	MAPT	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	8.344	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	8.670	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	10.590	NFE2L2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	11.004	NFE2L2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	13.170	NFE2L2	-	GI(Protien) :
ChEMBL	Potency	nM	12589.300	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	14125.400	MAPT	-	Target : CHEMBL1293224

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