Tan Lab | DSigDB

Gene Set: D4 : CTD - tibolone

Collection

D4 : CTD

Chemical Name

tibolone ( From PubChem : 5630-53-5 )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
312.446 g/mol	1	2	3.8826	True

Structure

InChI

InChI=1S/C21H28O2/c1-4-21(23)10-8-18-19-13(2)11-14-12-15(22)5-6-16(14)17(19)7-9-20(18,21)3/h1,13,17-19,23H,5-12H2,2-3H3

InChIKey

Links

Gene (14 / 22)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			CRP		C027385
CTD	increases(activity)			ESR1		C027385
CTD	increases(activity)			ESR2		C027385
CTD	increases(expression)			F3		C027385
CTD	decreases(expression)			ICAM1		C027385
CTD	decreases(phosphorylation)			MAPK1		C027385
CTD	decreases(phosphorylation)			MAPK3		C027385
CTD	increases(activity)			PGR		C027385
CTD	decreases(expression)			SELE		C027385
CTD	increases(expression)			SERPINE1		C027385
CTD	decreases(expression)			VCAM1		C027385
PubChem	Potency-Replicate_1	uM	0.003	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.004	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.005	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.043	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.065	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.004	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.013	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.025	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	23.708	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	9.521	NR3C1	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :

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