Tan Lab | DSigDB

Gene Set: D4 : CTD - 1,10-phenanthroline

Collection

D4 : CTD

Chemical Name

1,10-phenanthroline ( From PubChem : 1,10-PHENANTHROLINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
180.205 g/mol	0	2	2.783	True

Structure

InChI

InChI=1S/C12H8N2/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1/h1-8H

InChIKey

DGEZNRSVGBDHLK-UHFFFAOYSA-N

Links

Gene (107 / 175)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(expression)			ACE		C025205
CTD	decreases(expression)			AK1		C025205
CTD	increases(expression)			AKAP9		C025205
CTD	decreases(activity)			AKR1C1		C025205
CTD	decreases(activity)			AKR1C2		C025205
CTD	decreases(activity)			AKR1C3		C025205
CTD	decreases(activity)			AKR1C4		C025205
CTD	increases(expression)			ALDOA		C025205
CTD	increases(expression)			ALDOC		C025205
CTD	increases(expression)			ANKRD37		C025205
CTD	decreases(activity)			ANPEP		C025205
CTD	increases(reaction)			ANPEP		C025205
CTD	decreases(expression)			AQP3		C025205
CTD	decreases(activity)			ASPA		C025205
CTD	affects(localization)			ATF6		C025205
CTD	decreases(activity)			ATF6		C025205
CTD	decreases(cleavage)			ATF6		C025205
CTD	decreases(expression)			BNIP3L		C025205
CTD	increases(expression)			CA9		C025205
CTD	decreases(expression)			CAT		C025205
CTD	increases(expression)			CD83		C025205
CTD	increases(expression)			CD86		C025205
CTD	decreases(reaction)			CD86		C025205
CTD	increases(activity)			CFTR		C025205
CTD	increases(expression)			CXCL8		C025205
CTD	increases(expression)			EGLN1		C025205
CTD	decreases(expression)			EGLN2		C025205
CTD	increases(expression)			EGR1		C025205
CTD	increases(expression)			ENO1		C025205
CTD	increases(expression)			ENO2		C025205
CTD	decreases(expression)			ERCC2		C025205
CTD	increases(expression)			GAPDH		C025205
CTD	decreases(expression)			GPX3		C025205
CTD	increases(activity)			HIF1A		C025205
CTD	decreases(reaction)			HIF1A		C025205
CTD	increases(activity)			HIF1A		C025205
CTD	decreases(expression)			HIF3A		C025205
CTD	increases(expression)			HILPDA		C025205
CTD	increases(expression)			HK1		C025205
CTD	increases(expression)			HK2		C025205
CTD	decreases(expression)			HMOX1		C025205
CTD	decreases(reaction)			HMOX1		C025205
CTD	decreases(reaction)			HMOX1		C025205
CTD	increases(expression)			HMOX1		C025205
CTD	affects(reaction)			ICAM1		C025205
CTD	increases(expression)			ICAM1		C025205
CTD	decreases(expression)			IL1R1		C025205
CTD	decreases(reaction)			LAMC2		C025205
CTD	increases(degradation)			LAMC2		C025205
CTD	increases(expression)			LDHA		C025205
CTD	affects(localization)			MBTPS2		C025205
CTD	decreases(activity)			MBTPS2		C025205
CTD	decreases(cleavage)			MBTPS2		C025205
CTD	increases(expression)			MDM2		C025205
CTD	increases(expression)			MIF		C025205
CTD	decreases(activity)			MMP8		C025205
CTD	increases(expression)			NPPB		C025205
CTD	increases(expression)			NUB1		C025205
CTD	decreases(reaction)			OCLN		C025205
CTD	increases(degradation)			OCLN		C025205
CTD	increases(expression)			P4HA2		C025205
CTD	increases(expression)			PDK1		C025205
CTD	increases(expression)			PDK3		C025205
CTD	increases(expression)			PGK1		C025205
CTD	increases(expression)			PLOD3		C025205
CTD	decreases(expression)			PPP2R1B		C025205
CTD	decreases(expression)			PSPH		C025205
CTD	affects(reaction)			SELE		C025205
CTD	increases(expression)			SELE		C025205
CTD	increases(expression)			SERPINE1		C025205
CTD	decreases(expression)			SOD1		C025205
CTD	decreases(reaction)			SOD1		C025205
CTD	affects(cotreatment)			SOD1		C025205
CTD	decreases(expression)			SOD1		C025205
CTD	decreases(reaction)			SOD1		C025205
CTD	affects(cotreatment)			SOD2		C025205
CTD	decreases(reaction)			SOD2		C025205
CTD	increases(expression)			SOD2		C025205
CTD	affects(localization)			SREBF1		C025205
CTD	decreases(activity)			SREBF1		C025205
CTD	decreases(cleavage)			SREBF1		C025205
CTD	affects(localization)			STAT3		C025205
CTD	decreases(reaction)			STAT3		C025205
CTD	increases(expression)			TFRC		C025205
CTD	decreases(expression)			TIMM17A		C025205
CTD	decreases(reaction)			TIMM17A		C025205
CTD	increases(expression)			VEGFA		C025205
PubChem	Potency-Replicate_1	uM	54.982	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.490	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.647	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.719	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.783	AR	-	GI(Protien) :
PubChem	Potency	uM	2.818	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	15.496	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	24.337	AR	-	GI(Protien) :
PubChem	None	uM		ARNT	-	GI(Protien) :
PubChem	Potency	uM	6.510	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	3.548	ATXN2	-	GI(Protien) :
PubChem	Potency	uM	1.585	BAZ2B	-	GI(Protien) :
PubChem	None	uM		CASP1	-	GI(Protien) :
PubChem	Potency	uM	1.122	CBFB	-	GI(Protien) :
PubChem	Potency	uM	8.912	CBFB	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	6.169	CYP19A1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	9.688	CYP19A1	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		DRD3	-	GI(Protien) :
PubChem	Potency	uM	12.589	EHMT2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	4.900	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	5.448	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	6.169	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	7.761	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	7.997	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	13.801	ESR1	-	GI(Protien) :
PubChem	AC50_uM	uM	7.106	HSP90AA1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	1.025	HSPB1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	1.737	HSPB1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	2.187	HSPB1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	2.477	HSPB1	-	GI(Protien) :
PubChem	Potency	uM	10.000	HTT	-	GI(Protien) :
PubChem	Potency	uM	7.308	IDH1	-	GI(Protien) :
PubChem	None	uM		KCNH2	-	GI(Protien) :
PubChem	Potency	uM	28.184	MAPT	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		MITF	-	GI(Protien) :
PubChem	Potency	uM	0.046	MTOR	-	GI(Protien) :
PubChem	Potency	uM	4.645	MTOR	-	GI(Protien) :
PubChem	Potency	uM	5.805	NFE2L2	-	GI(Protien) :
PubChem	None	uM		NLRP1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	10.962	NR1H4	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	13.801	NR1H4	-	GI(Protien) :
PubChem	None	uM		NR1H4	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
PubChem	None	uM		NR5A1	-	GI(Protien) :
PubChem	None	uM		NR5A2	-	GI(Protien) :
PubChem	None	uM		PAX8	-	GI(Protien) :
PubChem	Potency	uM	17.783	PPARD	-	GI(Protien) :
PubChem	None	uM		PPARD	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	1.563	PPARG	-	GI(Protien) :
PubChem	None	uM		PRNP	-	GI(Protien) :
PubChem	None	uM		PRNP	-	GI(Protien) :
PubChem	None	uM		RBBP8	-	GI(Protien) :
PubChem	Potency	uM	1.122	RUNX1	-	GI(Protien) :
PubChem	Potency	uM	8.912	RUNX1	-	GI(Protien) :
PubChem	None	uM		SIX1	-	GI(Protien) :
PubChem	None	uM		SLC5A7	-	GI(Protien) :
PubChem	None	uM		SLC5A7	-	GI(Protien) :
PubChem	None	uM		SLC5A7	-	GI(Protien) :
PubChem	None	uM		TACC3	-	GI(Protien) :
PubChem	Potency	uM	3.663	TDP1	-	GI(Protien) :
PubChem	Potency	uM	4.109	TDP1	-	GI(Protien) :
PubChem	Potency	uM	5.012	TDP1	-	GI(Protien) :
PubChem	Potency	uM	5.012	TDP1	-	GI(Protien) :
PubChem	None	uM		TNNC1	-	GI(Protien) :
PubChem	None	uM		TNNI3	-	GI(Protien) :
PubChem	None	uM		TNNT2	-	GI(Protien) :
PubChem	Potency	uM	3.162	TP53	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	3.889	VDR	-	GI(Protien) :
ChEMBL	Potency	nM	6510.400	ATAD5	-	Target : CHEMBL1741209
ChEMBL	Potency	nM	1584.900	BAZ2B	-	Target : CHEMBL1741220
ChEMBL	Potency	nM	8912.500	CBFB	-	Target : CHEMBL2093862
ChEMBL	Potency	nM	1122.000	CBFB	-	Target : CHEMBL2093862
ChEMBL	Potency	nM	12589.300	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	10000.000	HTT	-	Target : CHEMBL5514
ChEMBL	Potency	nM	28183.800	KDM4A	-	Target : CHEMBL5896
ChEMBL	Potency	nM	251.200	KDM4E	-	Target : CHEMBL1293226
ChEMBL	Potency	nM	28183.800	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	46.500	MTOR	-	Target : CHEMBL2842
ChEMBL	Potency	nM	4645.100	MTOR	-	Target : CHEMBL2842
ChEMBL	Potency	nM	5804.800	NFE2L2	-	Target : CHEMBL1075094
ChEMBL	Potency	nM	8912.500	RUNX1	-	Target : CHEMBL2093862
ChEMBL	Potency	nM	1122.000	RUNX1	-	Target : CHEMBL2093862
ChEMBL	Potency	nM	3162.300	TP53	-	Target : CHEMBL4096

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