Tan Lab | DSigDB

Gene Set: D4 : CTD - Lindane

Collection

D4 : CTD

Chemical Name

Lindane ( From PubChem : LINDANE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
290.83 g/mol	0	0	3.6444	True

Structure

InChI

InChI=1S/C6H6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H/t1-,2-,3-,4-,5+,6+/m0/s1

InChIKey

JLYXXMFPNIAWKQ-LKPKBOIGSA-N

Links

Gene (132 / 321)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			ABCA1		D001556
CTD	increases(expression)			ABCB1		D001556
CTD	increases(expression)			ABCG1		D001556
CTD	increases(expression)			ABCG2		D001556
CTD	increases(expression)			ACRC		D001556
CTD	decreases(expression)			AK4		D001556
CTD	increases(expression)			ALDH8A1		D001556
CTD	affects(binding)			AR		C040534
CTD	decreases(reaction)			AR		C040534
CTD	increases(activity)			AR		C040534
CTD	decreases(reaction)			AR		C040534
CTD	increases(activity)			AR		C040534
CTD	decreases(reaction)			AR		C040534
CTD	increases(activity)			AR		C040534
CTD	affects(binding)			AR		C086916
CTD	decreases(reaction)			AR		C086916
CTD	increases(activity)			AR		C086916
CTD	affects(cotreatment)			AR		D001556
CTD	decreases(reaction)			AR		D001556
CTD	increases(expression)			AR		D001556
CTD	increases(expression)			ASNS		D001556
CTD	decreases(expression)			BAX		D001556
CTD	decreases(reaction)			BAX		D001556
CTD	increases(expression)			BAX		D001556
CTD	increases(reaction)			BAX		D001556
CTD	increases(expression)			BAX		D001556
CTD	affects(cotreatment)			BCL2		D001556
CTD	increases(expression)			BCL2		D001556
CTD	decreases(expression)			BCL2		D001556
CTD	increases(expression)			BCL2		D001556
CTD	increases(expression)			BCL2		D001556
CTD	increases(expression)			BCL6		D001556
CTD	increases(expression)			BIRC3		D001556
CTD	decreases(reaction)			BRCA1		C023888
CTD	increases(expression)			BRCA1		C023888
CTD	decreases(expression)			C15ORF39		D001556
CTD	increases(expression)			C5ORF28		D001556
CTD	increases(expression)			CARS		D001556
CTD	increases(activity)			CAT		D001556
CTD	increases(expression)			CCND1		C023888
CTD	decreases(reaction)			CCND1		C023888
CTD	increases(expression)			CCNG2		D001556
CTD	increases(expression)			CD69		D001556
CTD	increases(expression)			CD84		D001556
CTD	affects(reaction)			CDKN1A		D001556
CTD	increases(expression)			CDKN1A		D001556
CTD	decreases(reaction)			CDKN1A		D001556
CTD	decreases(expression)			CDKN1A		D001556
CTD	increases(expression)			CDKN1A		D001556
CTD	increases(expression)			CEBPB		D001556
CTD	increases(expression)			CHAC1		D001556
CTD	increases(expression)			CRIM1		D001556
CTD	decreases(expression)			CX3CR1		D001556
CTD	decreases(reaction)			CYP11A1		D001556
CTD	increases(expression)			CYP11A1		D001556
CTD	decreases(expression)			CYP11A1		D001556
CTD	decreases(reaction)			CYP11B1		D001556
CTD	increases(expression)			CYP11B1		D001556
CTD	decreases(reaction)			CYP11B2		D001556
CTD	increases(expression)			CYP11B2		D001556
CTD	decreases(reaction)			CYP17A1		D001556
CTD	increases(expression)			CYP17A1		D001556
CTD	decreases(reaction)			CYP19A1		D001556
CTD	increases(expression)			CYP19A1		D001556
CTD	decreases(activity)			CYP19A1		D001556
CTD	increases(activity)			CYP19A1		D001556
CTD	decreases(reaction)			CYP1A1		D001556
CTD	increases(expression)			CYP1A1		D001556
CTD	increases(expression)			CYP2B6		D001556
CTD	increases(expression)			CYP2B6		D001556
CTD	decreases(expression)			CYP2D6		D001556
CTD	decreases(response to substance)			CYP2E1		D001556
CTD	decreases(expression)			CYP2E1		D001556
CTD	increases(expression)			CYP3A4		D001556
CTD	increases(expression)			CYP3A7		D001556
CTD	increases(expression)			DAP3		D001556
CTD	increases(expression)			DNAJB4		D001556
CTD	increases(expression)			DUSP10		D001556
CTD	affects(binding)			ERBB2		C023888
CTD	increases(reaction)			ERBB2		C023888
CTD	decreases(reaction)			ERBB2		C023888
CTD	increases(activity)			ERBB2		C023888
CTD	increases(expression)			ERBB2		C023888
CTD	affects(binding)			ERBB3		C023888
CTD	increases(reaction)			ERBB3		C023888
CTD	decreases(reaction)			ERBB3		C023888
CTD	decreases(expression)			ESR1		C023888
CTD	decreases(reaction)			ESR1		C023888
CTD	decreases(expression)			ESR1		C023888
CTD	increases(activity)			ESR1		C023888
CTD	increases(expression)			ESR1		C023888
CTD	increases(activity)			ESR1		C086916
CTD	affects(cotreatment)			ESR1		D001556
CTD	increases(expression)			ESR1		D001556
CTD	affects(binding)			ESR1		D001556
CTD	affects(cotreatment)			ESR1		D001556
CTD	increases(expression)			ESR1		D001556
CTD	affects(binding)			ESR1		D001556
CTD	decreases(reaction)			ESR1		D001556
CTD	increases(activity)			ESR2		C040534
CTD	increases(activity)			ESR2		C023888
CTD	increases(activity)			ESR2		C086916
CTD	increases(activity)			ESR2		D001556
CTD	increases(expression)			ESRRA		D001556
CTD	increases(expression)			EVI2A		D001556
CTD	increases(expression)			FAM107B		D001556
CTD	decreases(expression)			FAM213B		D001556
CTD	increases(expression)			FBXO32		D001556
CTD	increases(expression)			FRAT1		D001556
CTD	affects(binding)			GABRA1		C040534
CTD	decreases(reaction)			GABRA1		C040534
CTD	increases(activity)			GABRA1		C040534
CTD	increases(reaction)			GABRA1		C040534
CTD	affects(binding)			GABRA1		C086916
CTD	affects(cotreatment)			GABRA1		C086916
CTD	increases(activity)			GABRA1		C086916
CTD	increases(reaction)			GABRA1		C086916
CTD	decreases(reaction)			GABRA1		C086916
CTD	affects(binding)			GABRA1		C086916
CTD	increases(activity)			GABRA1		C086916
CTD	increases(reaction)			GABRA1		C086916
CTD	decreases(activity)			GABRA1		C086916
CTD	affects(binding)			GABRA1		D001556
CTD	decreases(reaction)			GABRA1		D001556
CTD	affects(binding)			GABRA1		D001556
CTD	decreases(reaction)			GABRA1		D001556
CTD	increases(activity)			GABRA1		D001556
CTD	increases(reaction)			GABRA1		D001556
CTD	affects(binding)			GABRA1		D001556
CTD	decreases(reaction)			GABRA1		D001556
CTD	increases(activity)			GABRA1		D001556
CTD	affects(binding)			GABRA2		D001556
CTD	decreases(reaction)			GABRA2		D001556
CTD	affects(binding)			GABRA4		C086916
CTD	decreases(activity)			GABRA4		C086916
CTD	affects(binding)			GABRA6		C086916
CTD	increases(activity)			GABRA6		C086916
CTD	increases(reaction)			GABRA6		C086916
CTD	affects(binding)			GABRA6		D001556
CTD	decreases(reaction)			GABRA6		D001556
CTD	increases(activity)			GABRA6		D001556
CTD	affects(binding)			GABRB1		C086916
CTD	increases(activity)			GABRB1		C086916
CTD	increases(reaction)			GABRB1		C086916
CTD	decreases(activity)			GABRB1		C086916
CTD	affects(binding)			GABRB1		D001556
CTD	affects(binding)			GABRB1		D001556
CTD	decreases(reaction)			GABRB1		D001556
CTD	increases(activity)			GABRB1		D001556
CTD	affects(binding)			GABRB2		C086916
CTD	decreases(activity)			GABRB2		C086916
CTD	affects(binding)			GABRB2		D001556
CTD	decreases(reaction)			GABRB2		D001556
CTD	affects(binding)			GABRB3		C040534
CTD	decreases(reaction)			GABRB3		C040534
CTD	increases(activity)			GABRB3		C040534
CTD	increases(reaction)			GABRB3		C040534
CTD	affects(binding)			GABRB3		C086916
CTD	affects(cotreatment)			GABRB3		C086916
CTD	increases(activity)			GABRB3		C086916
CTD	increases(reaction)			GABRB3		C086916
CTD	decreases(reaction)			GABRB3		C086916
CTD	affects(binding)			GABRB3		D001556
CTD	affects(binding)			GABRB3		D001556
CTD	decreases(reaction)			GABRB3		D001556
CTD	affects(binding)			GABRB3		D001556
CTD	decreases(reaction)			GABRB3		D001556
CTD	increases(activity)			GABRB3		D001556
CTD	increases(reaction)			GABRB3		D001556
CTD	affects(binding)			GABRG2		C040534
CTD	decreases(reaction)			GABRG2		C040534
CTD	increases(activity)			GABRG2		C040534
CTD	increases(reaction)			GABRG2		C040534
CTD	affects(binding)			GABRG2		C086916
CTD	affects(cotreatment)			GABRG2		C086916
CTD	increases(activity)			GABRG2		C086916
CTD	increases(reaction)			GABRG2		C086916
CTD	decreases(reaction)			GABRG2		C086916
CTD	affects(binding)			GABRG2		C086916
CTD	increases(activity)			GABRG2		C086916
CTD	increases(reaction)			GABRG2		C086916
CTD	decreases(activity)			GABRG2		C086916
CTD	affects(binding)			GABRG2		D001556
CTD	decreases(reaction)			GABRG2		D001556
CTD	affects(binding)			GABRG2		D001556
CTD	decreases(reaction)			GABRG2		D001556
CTD	increases(activity)			GABRG2		D001556
CTD	increases(reaction)			GABRG2		D001556
CTD	affects(binding)			GABRG2		D001556
CTD	decreases(reaction)			GABRG2		D001556
CTD	increases(activity)			GABRG2		D001556
CTD	affects(binding)			GABRR1		D001556
CTD	increases(expression)			GATA3		D001556
CTD	decreases(activity)			GLRA1		D001556
CTD	decreases(activity)			GLRA2		D001556
CTD	decreases(activity)			GLRA3		D001556
CTD	affects(cotreatment)			GNRH1		D001556
CTD	increases(expression)			GNRH1		D001556
CTD	increases(expression)			GPR18		D001556
CTD	increases(expression)			GPT2		D001556
CTD	affects(response to substance)			GSTM1		C023888
CTD	decreases(expression)			HMGCS1		D001556
CTD	decreases(reaction)			HSD3B2		D001556
CTD	increases(expression)			HSD3B2		D001556
CTD	decreases(expression)			HSD3B2		D001556
CTD	affects(localization)			HSPA1A		D001556
CTD	decreases(expression)			HYLS1		D001556
CTD	decreases(expression)			ID1		D001556
CTD	increases(expression)			IER3		D001556
CTD	decreases(expression)			IFNG		D001556
CTD	decreases(expression)			IL5		D001556
CTD	increases(expression)			ISL2		D001556
CTD	increases(phosphorylation)			JUN		D001556
CTD	increases(expression)			KIF21B		D001556
CTD	increases(expression)			KLHL24		D001556
CTD	increases(activity)			MAP2K1		D001556
CTD	increases(phosphorylation)			MAP2K1		D001556
CTD	increases(activity)			MAP2K2		D001556
CTD	increases(phosphorylation)			MAP2K2		D001556
CTD	decreases(expression)			MAPK1		C023888
CTD	increases(activity)			MAPK1		C023888
CTD	increases(phosphorylation)			MAPK1		C023888
CTD	decreases(reaction)			MAPK1		D001556
CTD	increases(phosphorylation)			MAPK1		D001556
CTD	increases(activity)			MAPK1		D001556
CTD	decreases(expression)			MAPK3		C023888
CTD	increases(activity)			MAPK3		C023888
CTD	increases(phosphorylation)			MAPK3		C023888
CTD	decreases(reaction)			MAPK3		D001556
CTD	increases(phosphorylation)			MAPK3		D001556
CTD	increases(activity)			MAPK3		D001556
CTD	increases(expression)			MMP9		C023888
CTD	increases(expression)			MTHFD2		D001556
CTD	decreases(expression)			NANOS1		D001556
CTD	increases(expression)			NCOA7		D001556
CTD	decreases(expression)			NFE2L3		D001556
CTD	increases(expression)			NOS2		D001556
CTD	affects(binding)			NR1I2		C040534
CTD	increases(activity)			NR1I2		C040534
CTD	affects(binding)			NR1I2		C023888
CTD	increases(activity)			NR1I2		C023888
CTD	affects(binding)			NR1I2		C086916
CTD	increases(activity)			NR1I2		C086916
CTD	affects(binding)			NR1I2		D001556
CTD	increases(activity)			NR1I2		D001556
CTD	increases(activity)			NR1I2		D001556
CTD	increases(expression)			NRF1		D001556
CTD	increases(expression)			PDCD4		D001556
CTD	increases(expression)			PELI1		D001556
CTD	decreases(reaction)			PGR		C023888
CTD	increases(expression)			PGR		C023888
CTD	increases(expression)			PGR		C023888
CTD	increases(expression)			PGR		C023888
CTD	decreases(reaction)			PGR		C023888
CTD	increases(expression)			PGR		C023888
CTD	affects(binding)			PGR		D001556
CTD	decreases(reaction)			PGR		D001556
CTD	affects(cotreatment)			PGR		D001556
CTD	decreases(expression)			PGR		D001556
CTD	increases(expression)			PLCL1		D001556
CTD	increases(expression)			PNRC1		D001556
CTD	affects(cotreatment)			POMC		D001556
CTD	increases(expression)			POMC		D001556
CTD	increases(expression)			PPARGC1A		D001556
CTD	increases(expression)			PPRC1		D001556
CTD	increases(activity)			RAF1		D001556
CTD	increases(phosphorylation)			RAF1		D001556
CTD	increases(activity)			RARA		D001556
CTD	decreases(expression)			RGS2		D001556
CTD	increases(activity)			RXRB		D001556
CTD	decreases(expression)			SEMA3G		D001556
CTD	increases(expression)			SESN2		D001556
CTD	increases(expression)			SGK1		D001556
CTD	affects(binding)			SHBG		C086916
CTD	decreases(reaction)			SHBG		C086916
CTD	affects(binding)			SHBG		D001556
CTD	decreases(reaction)			SHBG		D001556
CTD	decreases(expression)			SLC10A1		D001556
CTD	decreases(activity)			SLC22A1		D001556
CTD	increases(expression)			SLC3A2		D001556
CTD	increases(expression)			SLC7A11		D001556
CTD	increases(activity)			SRC		C023888
CTD	increases(phosphorylation)			SRC		C023888
CTD	increases(expression)			STAM2		D001556
CTD	decreases(reaction)			STAR		D001556
CTD	increases(expression)			STAR		D001556
CTD	decreases(expression)			SULT2A1		D001556
CTD	increases(reaction)			SULT2A1		D001556
CTD	increases(expression)			TFAM		D001556
CTD	increases(expression)			TFB2M		D001556
CTD	decreases(reaction)			TFF1		C023888
CTD	increases(expression)			TFF1		C023888
CTD	increases(expression)			TFF1		C023888
CTD	decreases(reaction)			TFF1		C023888
CTD	increases(expression)			TFF1		C023888
CTD	increases(expression)			TM6SF1		D001556
CTD	decreases(expression)			TMCO6		D001556
CTD	decreases(expression)			TMEM177		D001556
CTD	decreases(expression)			TNF		D001556
CTD	affects(cotreatment)			TP53		D001556
CTD	increases(expression)			TP53		D001556
CTD	increases(expression)			TRIB3		D001556
CTD	increases(expression)			VEGFA		D001556
CTD	increases(expression)			VLDLR		D001556
CTD	decreases(expression)			ZNF628		D001556
PubChem	None	uM		CHRM1	-	GI(Protien) :
PubChem	None	uM		CHRM5	-	GI(Protien) :
PubChem	None	uM		CHRM5	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	54.483	CYP19A1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.195	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	3.857	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	7.641	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	9.688	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	19.725	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	48.978	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	49.956	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	49.956	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM		ESR1	-	GI(Protien) :
PubChem	None	uM		MRGPRX1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	44.668	NR1I2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	52.873	PPARD	-	GI(Protien) :

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