Tan Lab | DSigDB

Gene Set: D4 : CTD - perfluorooctanoic acid

Collection

D4 : CTD

Chemical Name

perfluorooctanoic acid ( From PubChem : PENTADECAFLUOROOCTANOIC ACID )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
414.068 g/mol	1	2	4.4451	True

Structure

InChI

InChI=1S/C8HF15O2/c9-2(10,1(24)25)3(11,12)4(13,14)5(15,16)6(17,18)7(19,20)8(21,22)23/h(H,24,25)

InChIKey

SNGREZUHAYWORS-UHFFFAOYSA-N

Links

Gene (203 / 266)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(activity)			ABCB1		C023036
CTD	decreases(activity)			ABCC1		C023036
CTD	decreases(activity)			ABCC4		C023036
CTD	increases(transport)			ABCG2		C023036
CTD	decreases(activity)			ABCG2		C023036
CTD	affects(cotreatment)			ACADM		C023036
CTD	increases(expression)			ACADM		C023036
CTD	increases(expression)			ACOX1		C023036
CTD	decreases(expression)			ACP1		C023036
CTD	increases(expression)			ACSL1		C023036
CTD	decreases(expression)			ACTL7B		C023036
CTD	decreases(expression)			ACTRT2		C023036
CTD	increases(expression)			ACY1		C023036
CTD	increases(expression)			ADAMTSL2		C023036
CTD	decreases(expression)			ADAMTSL5		C023036
CTD	decreases(expression)			ADI1		C023036
CTD	decreases(expression)			ADIPOQ		C023036
CTD	decreases(expression)			AKR1C1		C023036
CTD	affects(folding)			ALB		C023036
CTD	affects(binding)			ALB		C023036
CTD	affects(binding)			ALB		C023036
CTD	decreases(folding)			ALB		C023036
CTD	decreases(expression)			ALDH7A1		C023036
CTD	decreases(expression)			ALPL		C023036
CTD	decreases(expression)			ALPP		C023036
CTD	decreases(expression)			AMD1		C023036
CTD	increases(expression)			ANGPTL4		C023036
CTD	decreases(expression)			AOC2		C023036
CTD	increases(expression)			APOA1		C023036
CTD	increases(expression)			APOA2		C023036
CTD	increases(expression)			APOA5		C023036
CTD	increases(expression)			APOE		C023036
CTD	increases(expression)			ARG2		C023036
CTD	increases(expression)			ASNA1		C023036
CTD	decreases(expression)			ATG14		C023036
CTD	increases(expression)			ATP5B		C023036
CTD	increases(expression)			ATP5C1		C023036
CTD	decreases(expression)			BCL2		C023036
CTD	decreases(expression)			C1QTNF5		C023036
CTD	decreases(expression)			CA9		C023036
CTD	decreases(expression)			CAMKK1		C023036
CTD	increases(cleavage)			CASP1		C023036
CTD	increases(expression)			CASP9		C023036
CTD	increases(activity)			CAT		C023036
CTD	affects(binding)			CDH1		C023036
CTD	decreases(activity)			CDH1		C023036
CTD	decreases(expression)			CDH1		C023036
CTD	decreases(reaction)			CDH1		C023036
CTD	increases(expression)			CDKN2A		C023036
CTD	increases(expression)			CDV3		C023036
CTD	decreases(expression)			CEL		C023036
CTD	increases(expression)			CES2		C023036
CTD	decreases(expression)			CKAP4		C023036
CTD	increases(expression)			CLOCK		C023036
CTD	decreases(expression)			CPS1		C023036
CTD	affects(expression)			CPT1A		C023036
CTD	increases(expression)			CPT1A		C023036
CTD	increases(expression)			CPT1B		C023036
CTD	increases(expression)			CPT2		C023036
CTD	increases(expression)			CRAT		C023036
CTD	decreases(expression)			CRLF1		C023036
CTD	increases(expression)			CROT		C023036
CTD	affects(binding)			CTNNB1		C023036
CTD	decreases(activity)			CTNNB1		C023036
CTD	decreases(expression)			CTNNB1		C023036
CTD	decreases(reaction)			CTNNB1		C023036
CTD	decreases(expression)			CTNND1		C023036
CTD	decreases(reaction)			CXCL8		C023036
CTD	increases(expression)			CXCL8		C023036
CTD	increases(secretion)			CXCL8		C023036
CTD	increases(expression)			CXCL8		C023036
CTD	affects(reaction)			CXCL8		C023036
CTD	decreases(expression)			CYP11A1		C023036
CTD	increases(expression)			CYP2B6		C023036
CTD	increases(expression)			CYP3A4		C023036
CTD	increases(expression)			CYP4A11		C023036
CTD	increases(expression)			CYP51A1		C023036
CTD	decreases(expression)			CYP7A1		C023036
CTD	increases(expression)			DDIT3		C023036
CTD	decreases(expression)			DDX19A		C023036
CTD	decreases(expression)			DHFR		C023036
CTD	increases(expression)			DNMT3A		C023036
CTD	decreases(expression)			DOCK7		C023036
CTD	decreases(expression)			DUSP9		C023036
CTD	decreases(expression)			EEF2		C023036
CTD	decreases(expression)			EFCC1		C023036
CTD	decreases(reaction)			EHHADH		C023036
CTD	increases(expression)			EHHADH		C023036
CTD	increases(expression)			ENTPD7		C023036
CTD	increases(expression)			ESD		C023036
CTD	affects(binding)			ESR1		C023036
CTD	increases(activity)			ESR1		C023036
CTD	decreases(expression)			F10		C023036
CTD	increases(expression)			FABP1		C023036
CTD	increases(expression)			FAIM2		C023036
CTD	decreases(expression)			FAM131B		C023036
CTD	increases(expression)			FAM71E1		C023036
CTD	decreases(expression)			FBXO24		C023036
CTD	increases(expression)			FDFT1		C023036
CTD	increases(expression)			FGFBP1		C023036
CTD	increases(expression)			FOLH1		C023036
CTD	decreases(expression)			FSCN1		C023036
CTD	decreases(expression)			FZD9		C023036
CTD	decreases(expression)			G3BP1		C023036
CTD	increases(expression)			GAD1		C023036
CTD	increases(expression)			GALNT2		C023036
CTD	increases(expression)			GFPT1		C023036
CTD	increases(expression)			GFPT2		C023036
CTD	increases(expression)			GK		C023036
CTD	decreases(expression)			GMPS		C023036
CTD	decreases(expression)			GOLGA3		C023036
CTD	increases(expression)			GPX3		C023036
CTD	increases(expression)			GSPT1		C023036
CTD	increases(activity)			GSR		C023036
CTD	increases(methylation)			GSTP1		C023036
CTD	increases(expression)			GYPE		C023036
CTD	increases(expression)			HADHA		C023036
CTD	decreases(expression)			HDC		C023036
CTD	decreases(expression)			HKDC1		C023036
CTD	increases(expression)			HMGCR		C023036
CTD	increases(expression)			HMGCS1		C023036
CTD	increases(expression)			HMGCS2		C023036
CTD	decreases(activity)			HNF1A		C023036
CTD	decreases(expression)			HNF1A		C023036
CTD	decreases(activity)			HNF4A		C023036
CTD	decreases(expression)			HNF4A		C023036
CTD	increases(expression)			HNRNPK		C023036
CTD	decreases(expression)			HOXB3		C023036
CTD	decreases(expression)			HOXB9		C023036
CTD	decreases(activity)			HSD11B1		C023036
CTD	decreases(expression)			HSD11B2		C023036
CTD	decreases(activity)			HSD17B3		C023036
CTD	increases(expression)			HSD17B4		C023036
CTD	decreases(expression)			HSPA4		C023036
CTD	decreases(secretion)			IL10		C023036
CTD	increases(expression)			IL1B		C023036
CTD	decreases(expression)			IL37		C023036
CTD	decreases(secretion)			IL4		C023036
CTD	increases(expression)			IL6		C023036
CTD	decreases(expression)			JAM3		C023036
CTD	increases(expression)			KITLG		C023036
CTD	decreases(expression)			KYNU		C023036
CTD	decreases(expression)			LCMT2		C023036
CTD	decreases(expression)			LGALS7B		C023036
CTD	increases(expression)			LIPG		C023036
CTD	increases(expression)			LRRC49		C023036
CTD	decreases(expression)			LTB4R2		C023036
CTD	decreases(expression)			MAGEE1		C023036
CTD	decreases(expression)			MARC2		C023036
CTD	decreases(expression)			MAT2A		C023036
CTD	decreases(expression)			MDFI		C023036
CTD	decreases(expression)			MESP1		C023036
CTD	decreases(expression)			MMP11		C023036
CTD	decreases(reaction)			MMP9		C023036
CTD	increases(secretion)			MMP9		C023036
CTD	affects(reaction)			MMP9		C023036
CTD	increases(expression)			MSMO1		C023036
CTD	decreases(expression)			NANS		C023036
CTD	increases(expression)			NDRG1		C023036
CTD	decreases(expression)			NFE2L2		C023036
CTD	increases(degradation)			NFKBIA		C023036
CTD	increases(expression)			NPEPPS		C023036
CTD	decreases(expression)			NSD1		C023036
CTD	increases(expression)			OLIG3		C023036
CTD	decreases(expression)			P3H4		C023036
CTD	decreases(expression)			PAFAH1B1		C023036
CTD	increases(expression)			PCK1		C023036
CTD	increases(expression)			PCK2		C023036
CTD	decreases(expression)			PDIA3		C023036
CTD	increases(expression)			PDK4		C023036
CTD	decreases(expression)			PEBP1		C023036
CTD	increases(expression)			PEX11A		C023036
CTD	increases(expression)			PFN2		C023036
CTD	increases(expression)			PHKA2		C023036
CTD	decreases(expression)			PIGM		C023036
CTD	increases(expression)			PIK3C2A		C023036
CTD	increases(expression)			PLIN2		C023036
CTD	increases(expression)			PLIN2		C023036
CTD	decreases(expression)			POLR1B		C023036
CTD	increases(expression)			POR		C023036
CTD	decreases(reaction)			PPARA		C023036
CTD	increases(activity)			PPARA		C023036
CTD	affects(binding)			PPARA		C023036
CTD	decreases(activity)			PPARA		C023036
CTD	decreases(expression)			PPARA		C023036
CTD	decreases(reaction)			PPARA		C023036
CTD	decreases(response to substance)			PPARA		C023036
CTD	affects(binding)			PPARA		C023036
CTD	increases(activity)			PPARA		C023036
CTD	increases(activity)			PPARA		C023036
CTD	affects(reaction)			PPARA		C023036
CTD	increases(expression)			PPARA		C023036
CTD	affects(cotreatment)			PPARA		C023036
CTD	decreases(reaction)			PPARA		C023036
CTD	affects(reaction)			PPARA		C023036
CTD	decreases(reaction)			PPARA		C023036
CTD	increases(secretion)			PPARA		C023036
CTD	decreases(expression)			PPARD		C023036
CTD	increases(activity)			PPARD		C023036
CTD	affects(binding)			PPARG		C023036
CTD	decreases(activity)			PPARG		C023036
CTD	decreases(response to substance)			PPARG		C023036
CTD	affects(binding)			PPARG		C023036
CTD	increases(activity)			PPARG		C023036
CTD	increases(activity)			PPARG		C023036
CTD	increases(expression)			PRTG		C023036
CTD	decreases(expression)			PSMC3		C023036
CTD	increases(expression)			PSMD2		C023036
CTD	increases(expression)			PTEN		C023036
CTD	increases(expression)			PTGS2		C023036
CTD	increases(expression)			RAD23B		C023036
CTD	decreases(expression)			RASL10B		C023036
CTD	affects(localization)			RELA		C023036
CTD	decreases(reaction)			RELA		C023036
CTD	increases(phosphorylation)			RELA		C023036
CTD	decreases(expression)			RIN3		C023036
CTD	decreases(expression)			RNF207		C023036
CTD	decreases(expression)			RRM2		C023036
CTD	affects(cotreatment)			RXRA		C023036
CTD	increases(expression)			RXRA		C023036
CTD	decreases(expression)			SCAMP5		C023036
CTD	decreases(expression)			SEMA6A		C023036
CTD	increases(expression)			SGOL1		C023036
CTD	decreases(expression)			SIX5		C023036
CTD	increases(import)			SLC22A11		C023036
CTD	increases(reaction)			SLC22A11		C023036
CTD	decreases(reaction)			SLC22A11		C023036
CTD	affects(cotreatment)			SLC22A12		C023036
CTD	decreases(reaction)			SLC22A12		C023036
CTD	increases(import)			SLC22A12		C023036
CTD	increases(expression)			SLC25A20		C023036
CTD	increases(expression)			SLC25A34		C023036
CTD	increases(expression)			SQLE		C023036
CTD	increases(expression)			SREBF1		C023036
CTD	decreases(expression)			STIP1		C023036
CTD	increases(expression)			STOML2		C023036
CTD	decreases(expression)			STRAP		C023036
CTD	decreases(expression)			SYMPK		C023036
CTD	affects(activity)			TEK		C023036
CTD	decreases(expression)			TENM3		C023036
CTD	decreases(expression)			TLR6		C023036
CTD	decreases(reaction)			TNF		C023036
CTD	increases(expression)			TNF		C023036
CTD	increases(secretion)			TNF		C023036
CTD	increases(expression)			TNF		C023036
CTD	affects(reaction)			TNF		C023036
CTD	increases(expression)			TPK1		C023036
CTD	decreases(expression)			TPMT		C023036
CTD	decreases(expression)			TPT1		C023036
CTD	decreases(expression)			TRAM2		C023036
CTD	decreases(expression)			TTC23		C023036
CTD	decreases(expression)			TUB		C023036
CTD	increases(expression)			TXNIP		C023036
CTD	decreases(expression)			UGDH		C023036
CTD	decreases(expression)			VPS29		C023036
CTD	increases(expression)			YOD1		C023036
CTD	increases(expression)			ZNF658B		C023036
CTD	decreases(expression)			ZNF697		C023036
CTD	decreases(expression)			ZNF784		C023036
PubChem	Potency-Replicate_1	uM	9.747	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	21.000	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	21.624	NFE2L2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	29.394	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	19.448	PPARD	-	GI(Protien) :
PubChem	None	uM		PPARD	-	GI(Protien) :
PubChem	None	uM		PPARG	-	GI(Protien) :

Download gene sets

gmt, text, Detailed text