Tan Lab | DSigDB

Gene Set: D4 : CTD - tanshinone

Collection

D4 : CTD

Chemical Name

tanshinone ( From PubChem : TANSHINONE I )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
276.286 g/mol	0	3	4.0956	True

Structure

InChI

InChI=1S/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-8H,1-2H3

InChIKey

AIGAZQPHXLWMOJ-UHFFFAOYSA-N

Links

Gene (106 / 133)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			ACADVL		C021751
CTD	increases(expression)			ACSL1		C021751
CTD	affects(binding)			AHR		C021751
CTD	increases(activity)			AHR		C021751
CTD	increases(expression)			AHR		C021751
CTD	increases(reaction)			AHR		C021751
CTD	decreases(expression)			ALDH1A3		C021751
CTD	decreases(expression)			ALDH3A2		C021751
CTD	increases(expression)			APOC1		C021751
CTD	increases(expression)			APOM		C021751
CTD	decreases(expression)			ASNS		C021751
CTD	decreases(expression)			ASS1		C021751
CTD	increases(expression)			ATP6V0B		C021751
CTD	increases(expression)			ATP6V1E1		C021751
CTD	increases(expression)			BAX		C021751
CTD	decreases(expression)			BCKDHB		C021751
CTD	decreases(expression)			BCL2		C021751
CTD	decreases(expression)			BIRC3		C021751
CTD	decreases(expression)			BIRC5		C021751
CTD	decreases(reaction)			BIRC5		C021751
CTD	increases(expression)			BIRC5		C021751
CTD	increases(expression)			CALCOCO2		C021751
CTD	increases(activity)			CASP3		C021751
CTD	increases(expression)			CASP3		C021751
CTD	decreases(expression)			CD33		C021751
CTD	increases(expression)			CDKN1A		C021751
CTD	decreases(expression)			CEACAM6		C021751
CTD	increases(expression)			CLU		C021751
CTD	decreases(expression)			COL6A1		C021751
CTD	increases(expression)			CST6		C021751
CTD	decreases(expression)			CXCL8		C021751
CTD	decreases(reaction)			CYP1A1		C021751
CTD	increases(expression)			CYP1A1		C021751
CTD	increases(reaction)			CYP1A1		C021751
CTD	increases(expression)			CYP1A1		C021751
CTD	decreases(reaction)			CYP1A2		C021751
CTD	increases(expression)			CYP1A2		C021751
CTD	increases(reaction)			CYP1A2		C021751
CTD	increases(expression)			CYP3A4		C021751
CTD	increases(reaction)			CYP3A4		C021751
CTD	affects(reaction)			CYP3A4		C021751
CTD	increases(expression)			DCK		C021751
CTD	increases(expression)			DUSP11		C021751
CTD	increases(expression)			DUSP5		C021751
CTD	decreases(expression)			DYRK4		C021751
CTD	increases(expression)			ENC1		C021751
CTD	decreases(expression)			ERCC1		C021751
CTD	decreases(reaction)			ERCC1		C021751
CTD	decreases(expression)			ETS2		C021751
CTD	increases(expression)			F2RL1		C021751
CTD	increases(expression)			FLAD1		C021751
CTD	increases(expression)			FOS		C021751
CTD	increases(expression)			GBA		C021751
CTD	increases(expression)			GFAP		C021751
CTD	increases(expression)			GRB7		C021751
CTD	decreases(expression)			GSTP1		C021751
CTD	increases(expression)			HDAC3		C021751
CTD	increases(expression)			ID2		C021751
CTD	increases(expression)			INPPL1		C021751
CTD	increases(expression)			ISG20		C021751
CTD	decreases(expression)			ITGA6		C021751
CTD	increases(expression)			ITGAM		C021751
CTD	decreases(expression)			LRP1		C021751
CTD	decreases(reaction)			LRP1		C021751
CTD	increases(expression)			LRP1		C021751
CTD	decreases(expression)			LRP5		C021751
CTD	decreases(expression)			LRP8		C021751
CTD	increases(expression)			MAOB		C021751
CTD	decreases(expression)			MAP3K1		C021751
CTD	decreases(expression)			MIPEP		C021751
CTD	decreases(expression)			MMP7		C021751
CTD	increases(expression)			MYBL2		C021751
CTD	decreases(expression)			MYC		C021751
CTD	increases(expression)			MYL1		C021751
CTD	increases(expression)			NAA10		C021751
CTD	increases(expression)			NDUFB2		C021751
CTD	increases(expression)			NDUFV1		C021751
CTD	decreases(expression)			NES		C021751
CTD	increases(expression)			NOS3		C021751
CTD	increases(expression)			NR1I2		C021751
CTD	increases(reaction)			NR1I2		C021751
CTD	increases(activity)			NR1I2		C021751
CTD	affects(reaction)			NR1I3		C021751
CTD	increases(expression)			NR1I3		C021751
CTD	affects(reaction)			NR3C1		C021751
CTD	increases(expression)			NR3C1		C021751
CTD	increases(expression)			PARP4		C021751
CTD	increases(expression)			PCSK7		C021751
CTD	decreases(expression)			PLOD2		C021751
CTD	decreases(expression)			PRPF6		C021751
CTD	increases(expression)			PSMB5		C021751
CTD	increases(expression)			PSMD2		C021751
CTD	decreases(reaction)			PTGS2		C021751
CTD	increases(expression)			PTGS2		C021751
CTD	decreases(expression)			PTPRK		C021751
CTD	increases(expression)			RHOC		C021751
CTD	increases(expression)			SEPHS2		C021751
CTD	decreases(expression)			SP2		C021751
CTD	increases(expression)			TESK1		C021751
CTD	decreases(expression)			TFAP4		C021751
CTD	increases(expression)			TK1		C021751
CTD	decreases(expression)			TP53		C021751
CTD	increases(expression)			TP53		C021751
CTD	increases(expression)			WFDC2		C021751
PubChem	None	uM		APAF1	-	GI(Protien) :
PubChem	Potency	uM	10.000	ATXN2	-	GI(Protien) :
PubChem	Potency	uM	35.481	BAZ2B	-	GI(Protien) :
PubChem	None	uM		DNMT1	-	GI(Protien) :
PubChem	IC50	uM		EIF4H	-	GI(Protien) :
PubChem	None	uM		FASN	-	GI(Protien) :
PubChem	None	uM		GAPDH	-	GI(Protien) :
PubChem	Potency	uM	5.173	GMNN	-	GI(Protien) :
PubChem	None	uM		GSTO1	-	GI(Protien) :
PubChem	None	uM		GSTO1	-	GI(Protien) :
PubChem	None	uM		LYPLA2	-	GI(Protien) :
PubChem	None	uM		MAP4K2	-	GI(Protien) :
PubChem	Potency	uM	1.995	MAPT	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	IC50	uM		PABPC1	-	GI(Protien) :
PubChem	None	uM		PAFAH2	-	GI(Protien) :
PubChem	None	uM		PLA2G7	-	GI(Protien) :
PubChem	Potency	uM	19.953	POLB	-	GI(Protien) :
PubChem	Potency	uM	28.184	POLH	-	GI(Protien) :
PubChem	Potency	uM	79.433	POLK	-	GI(Protien) :
PubChem	Potency	uM	2.909	TDP1	-	GI(Protien) :
PubChem	Potency	uM	4.611	TDP1	-	GI(Protien) :
PubChem	None	uM		TNFRSF10B	-	GI(Protien) :
PubChem	Potency	uM	28.184	USP1	-	GI(Protien) :
ChEMBL	Potency	nM	35481.300	BAZ2B	-	Target : CHEMBL1741220
ChEMBL	Potency	nM	35481.300	KDM4A	-	Target : CHEMBL5896
ChEMBL	Potency	nM	1995.300	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	19952.600	POLB	-	Target : CHEMBL2392

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