Tan Lab | DSigDB

Gene Set: D4 : CTD - rhein

Collection

D4 : CTD

Chemical Name

rhein ( From PubChem : RHEIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
284.22 g/mol	3	6	1.5714	True

Structure

InChI

InChI=1S/C15H8O6/c16-9-3-1-2-7-11(9)14(19)12-8(13(7)18)4-6(15(20)21)5-10(12)17/h1-5,16-17H,(H,20,21)

InChIKey

FCDLCPWAQCPTKC-UHFFFAOYSA-N

Links

Gene (44 / 71)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			AHR		C020491
CTD	increases(activity)			AHR		C020491
CTD	decreases(expression)			EGF		C020491
CTD	decreases(expression)			ERBB2		C020491
CTD	decreases(reaction)			HIF1A		C020491
CTD	increases(expression)			HIF1A		C020491
CTD	decreases(expression)			HIF1A		C020491
CTD	affects(localization)			NFKB1		C020491
CTD	decreases(activity)			NFKB1		C020491
CTD	decreases(expression)			PTGS2		C020491
CTD	affects(localization)			RELA		C020491
CTD	increases(reaction)			RELA		C020491
CTD	decreases(activity)			RELA		C020491
CTD	decreases(expression)			VEGFA		C020491
CTD	decreases(response to substance)			VEGFA		C020491
PubChem	Potency	uM	12.589	ALOX15	-	GI(Protien) :
PubChem	Potency	uM	50.119	BAZ2B	-	GI(Protien) :
PubChem	None	uM		BCL2L1	-	GI(Protien) :
PubChem	None	uM		BCL2L1	-	GI(Protien) :
PubChem	Potency	uM	35.481	BLM	-	GI(Protien) :
PubChem	None	uM		CASP6	-	GI(Protien) :
PubChem	None	uM		CCR6	-	GI(Protien) :
PubChem	None	uM		CTDSP1	-	GI(Protien) :
PubChem	None	uM		CXCR6	-	GI(Protien) :
PubChem	None	uM		DNMT1	-	GI(Protien) :
PubChem	Potency	uM	39.811	EHMT2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	39.711	ESR1	-	GI(Protien) :
PubChem	Potency	uM	4.256	FEN1	-	GI(Protien) :
PubChem	Potency	uM	22.387	GLS	-	GI(Protien) :
PubChem	None	uM		GSTO1	-	GI(Protien) :
PubChem	None	uM		HKDC1	-	GI(Protien) :
PubChem	IC50	uM	3.339	HSP90AA1	-	GI(Protien) :
PubChem	None	uM		HSP90AA1	-	GI(Protien) :
PubChem	Potency	uM	17.783	MAPT	-	GI(Protien) :
PubChem	None	uM		MCL1	-	GI(Protien) :
PubChem	None	uM		MCL1	-	GI(Protien) :
PubChem	None	uM		MCL1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	14.090	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	25.056	NFE2L2	-	GI(Protien) :
PubChem	None	uM		PAFAH2	-	GI(Protien) :
PubChem	None	uM		PLA2G7	-	GI(Protien) :
PubChem	Potency	uM	11.220	POLB	-	GI(Protien) :
PubChem	Potency	uM	50.119	POLH	-	GI(Protien) :
PubChem	Potency	uM	75.686	POLH	-	GI(Protien) :
PubChem	Potency	uM	39.811	POLI	-	GI(Protien) :
PubChem	Potency	uM	67.016	POLI	-	GI(Protien) :
PubChem	Potency	uM	0.794	POLK	-	GI(Protien) :
PubChem	Potency	uM	47.444	POLK		GI(Protien) :
PubChem	Potency	uM	50.119	POLK	-	GI(Protien) :
PubChem	None	uM		PRMT1	-	GI(Protien) :
PubChem	IC50	uM	19.620	PTPN7	-	GI(Protien) :
PubChem	None	uM		RBBP8	-	GI(Protien) :
PubChem	None	uM		RBBP9	-	GI(Protien) :
PubChem	None	uM		SIX1	-	GI(Protien) :
PubChem	Potency	uM	26.680	WRN	-	GI(Protien) :
ChEMBL	Potency	nM	12589.300	ALOX15	-	Target : CHEMBL2903
ChEMBL	Potency	nM	50118.700	BAZ2B	-	Target : CHEMBL1741220
ChEMBL	Potency	nM	35481.300	BLM	-	Target : CHEMBL1293237
ChEMBL	Potency	nM	39810.700	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	12589.300	HSD17B10	-	Target : CHEMBL4159
ChEMBL	IC50	nM	3339.300	HSP90AA1	-	Target : CHEMBL2095165
ChEMBL	IC50	nM	3339.300	HSP90AB1	-	Target : CHEMBL2095165
ChEMBL	Potency	nM	56234.100	KDM4A	-	Target : CHEMBL5896
ChEMBL	Potency	nM	28183.800	KDM4E	-	Target : CHEMBL1293226
ChEMBL	Potency	nM	14125.400	KDM4E	-	Target : CHEMBL1293226
ChEMBL	Potency	nM	17782.800	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	17782.800	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	11220.200	POLB	-	Target : CHEMBL2392
ChEMBL	IC50	nM	19620.000	PTPN7	-	Target : CHEMBL2219
ChEMBL	Potency	nM	125892.000	RECQL	-	Target : CHEMBL1293236
ChEMBL	Potency	nM	3162.300	RECQL	-	Target : CHEMBL1293236

Download gene sets

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