Tan Lab | DSigDB

Gene Set: D4 : Boss - fasudil hcl

Collection

D4 : Boss

Chemical Name

fasudil hcl ( From PubChem : FASUDIL HYDROCHLORIDE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
327.83 g/mol	2	5	3.3683	True

Structure

InChI

InChI=1S/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H

InChIKey

Links

Gene (39 / 52)

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Source	Type	Unit	Value	Gene	PMID	Other
BOSS	Text Mining			ABCA1
BOSS	Text Mining			AGT
BOSS	Text Mining			AURKB
BOSS	Text Mining			BCL2
BOSS	Text Mining			CASP3
BOSS	Text Mining			CDT1
BOSS	Text Mining			CTGF
BOSS	Text Mining			DIANPH
BOSS	Text Mining			EDN1
BOSS	Text Mining			GPR182
BOSS	Text Mining			ICAM1
BOSS	Text Mining			IL10
BOSS	Text Mining			IL6
BOSS	Text Mining			IRF6
BOSS	Text Mining			LDHA
BOSS	Text Mining			MMP2
BOSS	Text Mining			MMP9
BOSS	Text Mining			MPO
BOSS	Text Mining			PPP1R12A
BOSS	Text Mining			RAB1B
BOSS	Text Mining			RHO
BOSS	Text Mining			RHOD
BOSS	Text Mining			RNASEH2A
BOSS	Text Mining			ROCK1
BOSS	Text Mining			ROCK2
BOSS	Text Mining			SMAD2
BOSS	Text Mining			TNF
BOSS	Text Mining			VEGFA
PubChem	Potency	uM	10.322	ATAD5	-	GI(Protien) :
PubChem	None	uM		CFTR	-	GI(Protien) :
PubChem	None	uM		CFTR	-	GI(Protien) :
PubChem	IC50_CF-PAF_Mean	uM		CFTR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	13.333	CYP19A1	-	GI(Protien) :
PubChem	None	uM		CYP19A1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	6.682	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	8.413	ESR1	-	GI(Protien) :
PubChem	Potency	uM	12.589	HTT	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		PRKACA	-	GI(Protien) :
PubChem	None	uM		PRKACA	-	GI(Protien) :
PubChem	None	uM		PRKD1	-	GI(Protien) :
PubChem	None	uM		ROCK2	-	GI(Protien) :
PubChem	None	uM		ROCK2	-	GI(Protien) :
PubChem	EC50_uM	uM	9.583	STK33	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
ChEMBL	Potency	nM	10322.500	ATAD5	-	Target : CHEMBL1741209
ChEMBL	Potency	nM	12589.300	HTT	-	Target : CHEMBL5514
ChEMBL	Potency	nM	89125.100	KDM4A	-	Target : CHEMBL5896

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