DSigDB

Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : Boss - 2h-1-benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2r-cis)-

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Collection	D4 : Boss
Chemical Name	2h-1-benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2r-cis)- ( From PubChem : (-)-EPICATECHIN )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Approved Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 290.268 g/mol 5 6 1.5461 True
Structure
InChI	InChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15-/m1/s1
InChIKey	PFTAWBLQPZVEMU-UKRRQHHQSA-N
Links
Gene (69 / 76) ⊖ Less	Source Type Unit Value Gene PMID Assay Other BOSS Text Mining ABCA1 BOSS Text Mining ACHE BOSS Text Mining ALB BOSS Text Mining ATP1B1 BOSS Text Mining ATP8A2 BOSS Text Mining AURKB BOSS Text Mining BBS9 BOSS Text Mining BCL2 BOSS Text Mining BORA BOSS Text Mining CASP3 BOSS Text Mining CDT1 BOSS Text Mining COMT BOSS Text Mining CSH1 BOSS Text Mining CSN2 BOSS Text Mining CYBB BOSS Text Mining CYCS BOSS Text Mining DDR2 BOSS Text Mining DECR1 BOSS Text Mining EDN1 BOSS Text Mining EPHB2 BOSS Text Mining F3 BOSS Text Mining FAM109A BOSS Text Mining GINS1 BOSS Text Mining GPR182 BOSS Text Mining GPX1 BOSS Text Mining GYPE BOSS Text Mining HBB BOSS Text Mining HEBP1 BOSS Text Mining HMOX1 BOSS Text Mining IL27 BOSS Text Mining IL6 BOSS Text Mining INS BOSS Text Mining IRF6 BOSS Text Mining ISYNA1 BOSS Text Mining LDHA BOSS Text Mining MAPK3 BOSS Text Mining MMP2 BOSS Text Mining MMP9 BOSS Text Mining MPO BOSS Text Mining MTOR BOSS Text Mining NFKB2 BOSS Text Mining OPTN BOSS Text Mining PGP BOSS Text Mining PNPLA3 BOSS Text Mining POLD4 BOSS Text Mining PRG4 BOSS Text Mining PTGS1 BOSS Text Mining REXO1L1P BOSS Text Mining RHO BOSS Text Mining RNASEH2A BOSS Text Mining ROS1 BOSS Text Mining SLC7A1 BOSS Text Mining SOD1 BOSS Text Mining TAOK1 BOSS Text Mining TNF BOSS Text Mining TP53 BOSS Text Mining TYR BOSS Text Mining VEGFA PubChem IC50_Mean uM 0.407 ALPL - GI(Protien) : PubChem EC50_Mean uM 51.300 ALPPL2 - GI(Protien) : PubChem Potency uM 3.162 EHMT2 - GI(Protien) : PubChem Potency uM 10.000 EHMT2 - GI(Protien) : PubChem Potency uM 10.000 GAA - GI(Protien) : PubChem None uM GFER - GI(Protien) : PubChem None uM GSTO1 - GI(Protien) : PubChem Potency uM 89.125 POLI - GI(Protien) : PubChem Potency uM 89.125 POLK - GI(Protien) : PubChem IC50 uM 205.620 RACGAP1 - GI(Protien) : ChEMBL Activity - ALB - Target : CHEMBL3253 ChEMBL IC50 nM 407.000 ALPL - Target : CHEMBL5979 ChEMBL EC50 nM 51300.000 ALPPL2 - Target : CHEMBL3402 ChEMBL Potency nM 3162.300 EHMT2 - Target : CHEMBL6032 ChEMBL Potency nM 10000.000 EHMT2 - Target : CHEMBL6032 ChEMBL Inhibition - F2 - Target : CHEMBL204 ChEMBL Potency nM 10000.000 GAA - Target : CHEMBL2608 ChEMBL Potency nM 11220.200 KDM4E - Target : CHEMBL1293226
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