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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : Boss - a91a6666-86c8-4b33-b3ef-f74cd3cd7f47

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Collection	D4 : Boss
Chemical Name	a91a6666-86c8-4b33-b3ef-f74cd3cd7f47 ( From PubChem : KAEMPFEROL )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Approved Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 286.236 g/mol 4 6 2.2824 True
Structure
InChI	InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H
InChIKey	IYRMWMYZSQPJKC-UHFFFAOYSA-N
Links
Gene (68 / 95) ⊖ Less	Source Type Unit Value Gene PMID Assay Other BOSS Text Mining ABCA1 BOSS Text Mining ACHE BOSS Text Mining AKR1B1 BOSS Text Mining ATP8A2 BOSS Text Mining AURKB BOSS Text Mining BBS9 BOSS Text Mining BCL2 BOSS Text Mining CASP3 BOSS Text Mining CASP9 BOSS Text Mining CDT1 BOSS Text Mining CXXC1 BOSS Text Mining CYCS BOSS Text Mining CYGB BOSS Text Mining CYP2C8 BOSS Text Mining ESR1 BOSS Text Mining GPR182 BOSS Text Mining GPX1 BOSS Text Mining HMOX1 BOSS Text Mining IL4 BOSS Text Mining IL6 BOSS Text Mining INS BOSS Text Mining IRF6 BOSS Text Mining ISYNA1 BOSS Text Mining LCN1 BOSS Text Mining LDHA BOSS Text Mining MMP9 BOSS Text Mining MPO BOSS Text Mining MTOR BOSS Text Mining NFKB1 BOSS Text Mining OPTN BOSS Text Mining POLD4 BOSS Text Mining POMGNT2 BOSS Text Mining PTGS1 BOSS Text Mining REXO1L1P BOSS Text Mining RNASEH2A BOSS Text Mining RUNX2 BOSS Text Mining SLC7A1 BOSS Text Mining SOD1 BOSS Text Mining TNF BOSS Text Mining TP53 BOSS Text Mining TYR BOSS Text Mining XDH PubChem None uM ADAM10 - GI(Protien) : PubChem None uM ADAM17 - GI(Protien) : PubChem AhR Potency (uM) uM 30.513 AHR - GI(Protien) : PubChem AhR Potency (uM) uM 44.553 AHR - GI(Protien) : PubChem Ratio Potency (uM) uM 26.408 AR - GI(Protien) : PubChem None uM CHRM1 - GI(Protien) : PubChem IC50 uM 9.933 CTDSP1 - GI(Protien) : PubChem None uM CTDSP1 - GI(Protien) : PubChem None uM CTDSP1 - GI(Protien) : PubChem None uM CTDSP1 - GI(Protien) : PubChem None uM CYP19A1 - GI(Protien) : PubChem None uM CYP1A2 - GI(Protien) : PubChem None uM CYP1A2 - GI(Protien) : PubChem Potency uM 15.849 CYP2C9 - GI(Protien) : PubChem Potency uM 10.000 CYP2D6 - GI(Protien) : PubChem Potency uM 15.849 CYP2D6 - GI(Protien) : PubChem None uM CYP2D6 - GI(Protien) : PubChem Potency uM 15.849 CYP3A4 - GI(Protien) : PubChem Potency uM 7.943 ESR1 - GI(Protien) : PubChem Potency uM 8.912 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 18.431 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 21.797 ESR1 - GI(Protien) : PubChem Ratio Potency (uM) uM 21.797 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 24.238 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 26.264 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 27.441 ESR1 - GI(Protien) : PubChem Ratio Potency (uM) uM 33.040 ESR1 - GI(Protien) : PubChem Ratio Potency (uM) uM 33.246 ESR1 - GI(Protien) : PubChem EC50_uM uM 11.590 GSK3B - GI(Protien) : PubChem Potency uM 1.585 HIF1A - GI(Protien) : PubChem Potency uM 28.184 HPGD - GI(Protien) : PubChem Potency uM 12.589 MAPT - GI(Protien) : PubChem None uM MAPT - GI(Protien) : PubChem Potency uM 21.690 NFE2L2 - GI(Protien) : PubChem Potency-Replicate_1 uM 44.668 NR1I2 - GI(Protien) : PubChem None uM NR3C1 - GI(Protien) : PubChem None uM PAFAH1B3 - GI(Protien) : PubChem None uM PIM2 - GI(Protien) : PubChem Potency uM 25.119 POLH - GI(Protien) : PubChem Potency uM 79.433 POLI - GI(Protien) : PubChem Ratio Potency (uM) uM PPARG - GI(Protien) : PubChem IC50 uM 44.490 RACGAP1 - GI(Protien) : PubChem None uM STK16 - GI(Protien) : ChEMBL AC50 nM 79.430 CYP1A2 - Target : CHEMBL3356 ChEMBL Potency nM 15848.900 CYP2C9 - Target : CHEMBL3397 ChEMBL Potency nM 10000.000 CYP2D6 - Target : CHEMBL289 ChEMBL AC50 nM 10000.000 CYP2D6 - Target : CHEMBL289 ChEMBL Potency nM 15848.900 CYP2D6 - Target : CHEMBL289 ChEMBL Potency nM 15848.900 CYP3A4 - Target : CHEMBL340 ChEMBL Potency nM 1584.900 HIF1A - Target : CHEMBL4261 ChEMBL Potency nM 28183.800 HPGD - Target : CHEMBL1293255 ChEMBL Potency nM 15848.900 HSD17B10 - Target : CHEMBL4159 ChEMBL Potency nM 12589.300 MAPT - Target : CHEMBL1293224
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