Tan Lab | DSigDB

Gene Set: D4 : Boss - synestrin

Collection

D4 : Boss

Chemical Name

synestrin ( From PubChem : DIETHYLSTILBESTROL )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
268.35 g/mol	2	2	4.8286	True

Structure

InChI

InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+

InChIKey

RGLYKWWBQGJZGM-ISLYRVAYSA-N

Links

Gene (34 / 61)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
BOSS	Text Mining			AKR1B1
BOSS	Text Mining			BRD2
BOSS	Text Mining			CYP2C8
BOSS	Text Mining			DES
BOSS	Text Mining			EREG
BOSS	Text Mining			ESR1
BOSS	Text Mining			GCK
BOSS	Text Mining			KRT7
BOSS	Text Mining			PGR
BOSS	Text Mining			PRL
BOSS	Text Mining			SLC7A1
BOSS	Text Mining			STIM1
PubChem	None	uM		APAF1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	17.238	AR	-	GI(Protien) :
PubChem	AR Potency (uM)	uM	27.715	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	33.360	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	43.641	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	48.558	AR	-	GI(Protien) :
PubChem	AR Potency (uM)	uM	50.457	AR	-	GI(Protien) :
PubChem	None	uM		CHRM4	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	60.634	CYP19A1	-	GI(Protien) :
PubChem	Potency	uM	10.000	CYP3A4	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.000	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.001	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.002	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.004	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	30.654	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	48.966	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	48.966	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	54.040	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	54.040	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	54.483	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	54.483	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	54.511	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM		ESR1	-	GI(Protien) :
PubChem	None	uM		GFER	-	GI(Protien) :
PubChem	Potency	uM	23.715	GMNN	-	GI(Protien) :
PubChem	None	uM		GNA15	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	54.941	HSPB1	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	10.782	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	29.849	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	39.811	NR1H4	-	GI(Protien) :
PubChem	Potency	uM	44.668	NR1H4	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
PubChem	IC50	uM	12.589	SLC5A7	-	GI(Protien) :
PubChem	None	uM		SLC5A7	-	GI(Protien) :
PubChem	None	uM		SLC5A7	-	GI(Protien) :
PubChem	None	uM		TAAR1	-	GI(Protien) :
PubChem	None	uM		TNNC1	-	GI(Protien) :
PubChem	None	uM		TNNI3	-	GI(Protien) :
PubChem	None	uM		TNNT2	-	GI(Protien) :
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	10000.000	CYP3A4	-	Target : CHEMBL340

Download gene sets

gmt, text, Detailed text