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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : Boss - rcra waste number u010

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Collection	D4 : Boss
Chemical Name	rcra waste number u010 ( From PubChem : MITOMYCIN C )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Approved Not Not Approved Approved Approved Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 334.327 g/mol 3 9 0.0161 True
Structure
InChI	InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
InChIKey	NWIBSHFKIJFRCO-WUDYKRTCSA-N
Links
Gene (80 / 88) ⊖ Less	Source Type Unit Value Gene PMID Assay Other BOSS Text Mining ABCA1 BOSS Text Mining ABCG2 BOSS Text Mining ATM BOSS Text Mining ATP1B1 BOSS Text Mining ATP8A2 BOSS Text Mining ATR BOSS Text Mining BCL2 BOSS Text Mining BCL2L1 BOSS Text Mining BRCA1 BOSS Text Mining C7orf49 BOSS Text Mining CASP3 BOSS Text Mining CD4 BOSS Text Mining CD44 BOSS Text Mining CDKN2A BOSS Text Mining CDT1 BOSS Text Mining CHEK1 BOSS Text Mining CHEK2 BOSS Text Mining CHRDL1 BOSS Text Mining CYCS BOSS Text Mining CYP2C8 BOSS Text Mining DCR BOSS Text Mining DDR2 BOSS Text Mining EGF BOSS Text Mining EGFR BOSS Text Mining ELF3 BOSS Text Mining FANCI BOSS Text Mining FGF13 BOSS Text Mining FN1 BOSS Text Mining FSCN1 BOSS Text Mining FXN BOSS Text Mining GP1BB BOSS Text Mining H2AFX BOSS Text Mining HFM1 BOSS Text Mining HPD BOSS Text Mining HRAS BOSS Text Mining HUWE1 BOSS Text Mining IL10 BOSS Text Mining IL2 BOSS Text Mining IL6 BOSS Text Mining INS BOSS Text Mining KALRN BOSS Text Mining LDHA BOSS Text Mining MAPK3 BOSS Text Mining MYC BOSS Text Mining NANOGP8 BOSS Text Mining NSG1 BOSS Text Mining OPTN BOSS Text Mining PALB2 BOSS Text Mining PARP2 BOSS Text Mining PCNA BOSS Text Mining PGP BOSS Text Mining PLXNA3 BOSS Text Mining RHO BOSS Text Mining RPN2 BOSS Text Mining SLC22A3 BOSS Text Mining STX2 BOSS Text Mining TAF8 BOSS Text Mining TAS2R62P BOSS Text Mining TCOF1 BOSS Text Mining TNF BOSS Text Mining TP53 BOSS Text Mining TRAPPC9 BOSS Text Mining TSC1 BOSS Text Mining VEGFA BOSS Text Mining WASF1 BOSS Text Mining XRCC4 PubChem Potency-Replicate_1 uM 13.333 AR - GI(Protien) : PubChem AR Potency (uM) uM 16.154 AR - GI(Protien) : PubChem Potency-Replicate_1 uM 29.849 CYP19A1 - GI(Protien) : PubChem Potency-Replicate_1 uM 6.682 ESR1 - GI(Protien) : PubChem ER Potency (uM) uM 8.096 ESR1 - GI(Protien) : PubChem Ratio Potency (uM) uM 15.679 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 21.314 ESR1 - GI(Protien) : PubChem None uM NR1H4 - GI(Protien) : PubChem Potency-Replicate_1 uM 21.314 NR3C1 - GI(Protien) : PubChem None uM PPARD - GI(Protien) : PubChem None uM PPARG - GI(Protien) : PubChem None uM STK33 - GI(Protien) : PubChem Potency uM 0.009 TDP1 - GI(Protien) : PubChem Potency uM 0.009 TDP1 - GI(Protien) : PubChem Potency uM 0.581 TDP1 - GI(Protien) : PubChem Potency uM 0.731 TDP1 - GI(Protien) : ChEMBL Inhibition - CYP1A2 - Target : CHEMBL3356 ChEMBL Inhibition - CYP2C19 - Target : CHEMBL3622 ChEMBL Inhibition - CYP2C9 - Target : CHEMBL3397 ChEMBL Inhibition - CYP2D6 - Target : CHEMBL289 ChEMBL Inhibition - CYP3A4 - Target : CHEMBL340 ChEMBL Inhibition - CYP3A4 - Target : CHEMBL340
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