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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : Boss - rcra waste no. u059

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Collection	D4 : Boss
Chemical Name	rcra waste no. u059 ( From PubChem : DAUNORUBICIN )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Approved Not Approved Approved Not Approved Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 527.52 g/mol 5 11 1.7292 False(2/4)
Structure
InChI	InChI=1S/C27H29NO10/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3/t10-,14-,16-,17-,22+,27-/m0/s1
InChIKey	STQGQHZAVUOBTE-VGBVRHCVSA-N
Links
Gene (108 / 151) ⊖ Less	Source Type Unit Value Gene PMID Assay Other BOSS Text Mining ABCA1 BOSS Text Mining ABCG2 BOSS Text Mining ACE BOSS Text Mining AGT BOSS Text Mining AKR1B1 BOSS Text Mining ALB BOSS Text Mining ASRGL1 BOSS Text Mining ATM BOSS Text Mining ATP1B1 BOSS Text Mining ATP8A2 BOSS Text Mining AURKB BOSS Text Mining BCL2 BOSS Text Mining BCL2L1 BOSS Text Mining BRCA1 BOSS Text Mining CASP3 BOSS Text Mining CASP8 BOSS Text Mining CASP9 BOSS Text Mining CBR1 BOSS Text Mining CBR3 BOSS Text Mining CD34 BOSS Text Mining CD4 BOSS Text Mining CD8A BOSS Text Mining CDT1 BOSS Text Mining CEBPZ BOSS Text Mining CPEB1 BOSS Text Mining CSF3 BOSS Text Mining CYCS BOSS Text Mining DDR2 BOSS Text Mining DECR1 BOSS Text Mining EFS BOSS Text Mining EGF BOSS Text Mining EGFR BOSS Text Mining ELF3 BOSS Text Mining EPHB2 BOSS Text Mining ERBB2 BOSS Text Mining ERBB2 BOSS Text Mining EREG BOSS Text Mining ESR1 BOSS Text Mining F3 BOSS Text Mining GMPS BOSS Text Mining GPX1 BOSS Text Mining H2AFX BOSS Text Mining HBB BOSS Text Mining HEBP1 BOSS Text Mining HFM1 BOSS Text Mining HNF1B BOSS Text Mining IL6 BOSS Text Mining KIT BOSS Text Mining KRT5 BOSS Text Mining LDHA BOSS Text Mining MAPK3 BOSS Text Mining MCL1 BOSS Text Mining MFGE8 BOSS Text Mining MMP2 BOSS Text Mining MPO BOSS Text Mining NPM1 BOSS Text Mining NR4A1 BOSS Text Mining NSG1 BOSS Text Mining PARP2 BOSS Text Mining PGP BOSS Text Mining PGR BOSS Text Mining PLXNA3 BOSS Text Mining PML BOSS Text Mining POLD4 BOSS Text Mining PPARG BOSS Text Mining PR@ BOSS Text Mining PRAM1 BOSS Text Mining PRDX2 BOSS Text Mining PTEN BOSS Text Mining RARA BOSS Text Mining RHO BOSS Text Mining RNASEH2A BOSS Text Mining ROS1 BOSS Text Mining SH3PXD2A BOSS Text Mining SLC7A1 BOSS Text Mining STXBP1 BOSS Text Mining TENM1 BOSS Text Mining THM BOSS Text Mining TNFRSF10B BOSS Text Mining TOP2A BOSS Text Mining TP53 BOSS Text Mining TRAF3 BOSS Text Mining VEGFA BOSS Text Mining WLS PubChem Ratio Potency (uM) uM 0.952 AR - GI(Protien) : PubChem Potency-Replicate_1 uM 0.952 AR - GI(Protien) : PubChem Potency-Replicate_1 uM 2.131 AR - GI(Protien) : PubChem Potency-Replicate_1 uM 14.960 AR - GI(Protien) : PubChem Potency uM 14.125 BLM - GI(Protien) : PubChem Potency uM 16.231 BLM - GI(Protien) : PubChem Potency uM 28.184 BLM - GI(Protien) : PubChem Potency uM 0.251 CBFB - GI(Protien) : PubChem Potency-Replicate_1 uM 3.758 CYP19A1 - GI(Protien) : PubChem None uM CYP19A1 - GI(Protien) : PubChem None uM CYP1A2 - GI(Protien) : PubChem Potency uM 15.849 EHMT2 - GI(Protien) : PubChem Ratio Potency (uM) uM 0.477 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 0.477 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 0.531 ESR1 - GI(Protien) : PubChem Ratio Potency (uM) uM 7.562 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 8.485 ESR1 - GI(Protien) : PubChem None uM GNAI1 - GI(Protien) : PubChem Potency uM 2.239 HTT - GI(Protien) : PubChem Potency uM 4.467 MAPT - GI(Protien) : PubChem Potency uM 5.012 MAPT - GI(Protien) : PubChem Potency uM 25.119 MAPT - GI(Protien) : PubChem None uM MAPT - GI(Protien) : PubChem Potency-Replicate_1 uM 3.349 NR1H4 - GI(Protien) : PubChem None uM NR1H4 - GI(Protien) : PubChem Ratio Potency (uM) uM 0.700 NR3C1 - GI(Protien) : PubChem Potency uM 5.012 POLK - GI(Protien) : PubChem Potency uM 11.917 POLK - GI(Protien) : PubChem None uM PPARD - GI(Protien) : PubChem None uM PPARG - GI(Protien) : PubChem None uM RGS12 - GI(Protien) : PubChem Potency uM 0.251 RUNX1 - GI(Protien) : PubChem None uM STK33 - GI(Protien) : PubChem Potency uM 0.021 TDP1 - GI(Protien) : PubChem Potency uM 0.024 TDP1 - GI(Protien) : PubChem Potency uM 0.027 TDP1 - GI(Protien) : PubChem Potency uM 0.038 TDP1 - GI(Protien) : PubChem Potency uM 11.220 THRB - GI(Protien) : PubChem Potency uM 22.387 THRB - GI(Protien) : PubChem Potency uM 31.623 THRB - GI(Protien) : PubChem Potency uM 44.668 THRB - GI(Protien) : PubChem Potency uM 39.811 USP1 - GI(Protien) : PubChem Potency uM 44.668 USP1 - GI(Protien) : PubChem None uM VDR - GI(Protien) : ChEMBL Potency nM 10000.000 APEX1 - Target : CHEMBL5619 ChEMBL Potency nM 28183.800 BLM - Target : CHEMBL1293237 ChEMBL Potency nM 14125.400 BLM - Target : CHEMBL1293237 ChEMBL Potency nM 16231.300 BLM - Target : CHEMBL1293237 ChEMBL Potency nM 251.200 CBFB - Target : CHEMBL2093862 ChEMBL Potency nM 15848.900 EHMT2 - Target : CHEMBL6032 ChEMBL Inhibition - HDAC6 - Target : CHEMBL1865 ChEMBL Potency nM 2238.700 HTT - Target : CHEMBL5514 ChEMBL Potency nM 35481.300 KDM4E - Target : CHEMBL1293226 ChEMBL Potency nM 25118.900 MAPT - Target : CHEMBL1293224 ChEMBL Potency nM 4466.800 MAPT - Target : CHEMBL1293224 ChEMBL Potency nM 5011.900 MAPT - Target : CHEMBL1293224 ChEMBL Potency nM 31622.800 RECQL - Target : CHEMBL1293236 ChEMBL Potency nM 28183.800 RECQL - Target : CHEMBL1293236 ChEMBL Potency nM 251.200 RUNX1 - Target : CHEMBL2093862 ChEMBL Potency nM 11220.200 THRB - Target : CHEMBL1947 ChEMBL Potency nM 31622.800 THRB - Target : CHEMBL1947 ChEMBL Potency nM 22387.200 THRB - Target : CHEMBL1947 ChEMBL Potency nM 44668.400 THRB - Target : CHEMBL1947 ChEMBL Inhibition - TOP1 - Target : CHEMBL1781 ChEMBL Inhibition - TOP2A - Target : CHEMBL1806 ChEMBL Inhibition - TOP2A - Target : CHEMBL1806 ChEMBL Inhibition - TOP2A - Target : CHEMBL1806
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