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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : Boss - rapamycin-supplied by selleck chemicals

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Collection	D4 : Boss
Chemical Name	rapamycin-supplied by selleck chemicals ( From PubChem : SIROLIMUS )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Approved Approved Not Approved Approved Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 914.172 g/mol 3 14 6.1185 False(1/4)
Structure
InChI	InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12-,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38?,39?,40-,42+,43?,44-,46-,47+,51-/m1/s1
InChIKey	QFJCIRLUMZQUOT-MQTWOLQFSA-N
Links
Gene (198 / 220) ⊖ Less	Source Type Unit Value Gene PMID Assay Other BOSS Text Mining ABCA1 BOSS Text Mining ACE BOSS Text Mining AKT1S1 BOSS Text Mining AKT2 BOSS Text Mining ALB BOSS Text Mining ALDH1B1 BOSS Text Mining APP BOSS Text Mining ASPA BOSS Text Mining ATG12 BOSS Text Mining ATG7 BOSS Text Mining ATIC BOSS Text Mining ATM BOSS Text Mining ATP6V0A2 BOSS Text Mining ATP8A2 BOSS Text Mining AURKB BOSS Text Mining AWAT2 BOSS Text Mining BCL2 BOSS Text Mining BCL2L1 BOSS Text Mining BECN1 BOSS Text Mining C7orf49 BOSS Text Mining CASP3 BOSS Text Mining CASP9 BOSS Text Mining CD28 BOSS Text Mining CD34 BOSS Text Mining CD4 BOSS Text Mining CD40 BOSS Text Mining CD40LG BOSS Text Mining CD8A BOSS Text Mining CDH2 BOSS Text Mining CDKN2A BOSS Text Mining CDT1 BOSS Text Mining CEBPZ BOSS Text Mining COG3 BOSS Text Mining COX8C BOSS Text Mining CRTC1 BOSS Text Mining CRTC2 BOSS Text Mining CSF2 BOSS Text Mining CSF3 BOSS Text Mining CXCL12 BOSS Text Mining CYCS BOSS Text Mining CYP2C8 BOSS Text Mining DDIT4 BOSS Text Mining DDR2 BOSS Text Mining DES BOSS Text Mining DHFR BOSS Text Mining DIANPH BOSS Text Mining EDN1 BOSS Text Mining EGF BOSS Text Mining EGFR BOSS Text Mining EIF4A1 BOSS Text Mining EIF4EBP1 BOSS Text Mining ELF3 BOSS Text Mining EPHB2 BOSS Text Mining ERBB2 BOSS Text Mining ERBB2 BOSS Text Mining ESR1 BOSS Text Mining F3 BOSS Text Mining F9 BOSS Text Mining FABP4 BOSS Text Mining FAM109A BOSS Text Mining FIGF BOSS Text Mining FN1 BOSS Text Mining FOXO1 BOSS Text Mining FOXO3 BOSS Text Mining FOXP3 BOSS Text Mining GINS1 BOSS Text Mining GLI2 BOSS Text Mining GPR182 BOSS Text Mining HBA1 BOSS Text Mining HBB BOSS Text Mining HERC2 BOSS Text Mining HIF1A BOSS Text Mining HLP BOSS Text Mining HMOX1 BOSS Text Mining HPD BOSS Text Mining HRAS BOSS Text Mining HSPA5 BOSS Text Mining ICOS BOSS Text Mining IDE BOSS Text Mining IFNA1 BOSS Text Mining IFNG BOSS Text Mining IGF1 BOSS Text Mining IGF1R BOSS Text Mining IGFBP1 BOSS Text Mining IL10 BOSS Text Mining IL13 BOSS Text Mining IL15 BOSS Text Mining IL2 BOSS Text Mining IL27 BOSS Text Mining IL2RA BOSS Text Mining IL4 BOSS Text Mining IL6 BOSS Text Mining INS BOSS Text Mining INSR BOSS Text Mining IRF6 BOSS Text Mining IRS2 BOSS Text Mining IRS4 BOSS Text Mining JAK2 BOSS Text Mining JUP BOSS Text Mining KDR BOSS Text Mining KRT10 BOSS Text Mining KRT6B BOSS Text Mining KRT8 BOSS Text Mining LAMP1 BOSS Text Mining LDHA BOSS Text Mining LEP BOSS Text Mining MAP1LC3A BOSS Text Mining MAP1LC3B BOSS Text Mining MAP3K1 BOSS Text Mining MAPK3 BOSS Text Mining MAPKAP1 BOSS Text Mining MCL1 BOSS Text Mining MKNK1 BOSS Text Mining MMP2 BOSS Text Mining MMP9 BOSS Text Mining MMVP1 BOSS Text Mining MPP2 BOSS Text Mining MTOR BOSS Text Mining MTR BOSS Text Mining MYC BOSS Text Mining NELFCD BOSS Text Mining NFKB1 BOSS Text Mining NONO BOSS Text Mining NPHS1 BOSS Text Mining NPHS2 BOSS Text Mining NSG1 BOSS Text Mining NUP214 BOSS Text Mining NUP62 BOSS Text Mining OPTN BOSS Text Mining PAK3 BOSS Text Mining PARP2 BOSS Text Mining PAX3 BOSS Text Mining PCNA BOSS Text Mining PDK1 BOSS Text Mining PGP BOSS Text Mining PI3 BOSS Text Mining PIK3CD BOSS Text Mining PLAU BOSS Text Mining PNPLA3 BOSS Text Mining POLD4 BOSS Text Mining POMC BOSS Text Mining POTEF BOSS Text Mining PPARG BOSS Text Mining PPP2CB BOSS Text Mining PRDX2 BOSS Text Mining PRRT2 BOSS Text Mining PTEN BOSS Text Mining PTK2B BOSS Text Mining QRSL1 BOSS Text Mining RAC1 BOSS Text Mining RAPGEF5 BOSS Text Mining RASGRF1 BOSS Text Mining RHO BOSS Text Mining RNASEH2A BOSS Text Mining ROCK1 BOSS Text Mining RORC BOSS Text Mining ROS1 BOSS Text Mining RPS6 BOSS Text Mining RPS6KB1 BOSS Text Mining RYR1 BOSS Text Mining SART3 BOSS Text Mining SCARNA5 BOSS Text Mining SETD2 BOSS Text Mining SIRT1 BOSS Text Mining SLC22A3 BOSS Text Mining SLC25A20 BOSS Text Mining SLC7A1 BOSS Text Mining SOD1 BOSS Text Mining SREBF1 BOSS Text Mining SRL BOSS Text Mining SST BOSS Text Mining STAT1 BOSS Text Mining STAT3 BOSS Text Mining STIP1 BOSS Text Mining STK11 BOSS Text Mining STK38 BOSS Text Mining SYBU BOSS Text Mining TACR2 BOSS Text Mining TAOK1 BOSS Text Mining TAS2R62P BOSS Text Mining TAS2R63P BOSS Text Mining TCOF1 BOSS Text Mining TLK2 BOSS Text Mining TLR4 BOSS Text Mining TNF BOSS Text Mining TP53 BOSS Text Mining TRAPPC9 BOSS Text Mining TSC1 BOSS Text Mining UBASH3B BOSS Text Mining ULK1 BOSS Text Mining VEGFA BOSS Text Mining VIM BOSS Text Mining VIPR1 BOSS Text Mining YWHAG BOSS Text Mining ZMPSTE24 PubChem Ratio Potency (uM) uM 9.893 AR - GI(Protien) : PubChem Potency-Replicate_1 uM 10.682 AR - GI(Protien) : PubChem Potency-Replicate_1 uM 21.132 AR - GI(Protien) : PubChem Potency-Replicate_1 uM 23.710 AR - GI(Protien) : PubChem Potency-Replicate_1 uM 26.832 AR - GI(Protien) : PubChem Ratio Potency (uM) uM 26.832 AR - GI(Protien) : PubChem Potency-Replicate_1 uM 2.113 CYP19A1 - GI(Protien) : PubChem None uM CYP19A1 - GI(Protien) : PubChem ER Potency (uM) uM 0.003 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 0.004 ESR1 - GI(Protien) : PubChem ER Potency (uM) uM 0.005 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 0.007 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 16.930 NR3C1 - GI(Protien) : PubChem Potency-Replicate_1 uM 23.915 NR3C1 - GI(Protien) : PubChem Potency uM 0.002 TDP1 - GI(Protien) : PubChem Potency uM 0.005 TDP1 - GI(Protien) : PubChem Potency uM 0.008 TDP1 - GI(Protien) : PubChem Potency uM 0.012 TDP1 - GI(Protien) : PubChem Potency uM 4.467 TDP1 - GI(Protien) : ChEMBL Activity - MTOR - Target : CHEMBL2842 ChEMBL Activity - MTOR - Target : CHEMBL2842 ChEMBL Activity - MTOR - Target : CHEMBL2842 ChEMBL Activity - MTOR - Target : CHEMBL2842 ChEMBL Activity - MTOR - Target : CHEMBL2842 ChEMBL Activity - MTOR - Target : CHEMBL2842
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