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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : Boss - nchembio732-comp3

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Collection	D4 : Boss
Chemical Name	nchembio732-comp3 ( From PubChem : TAMOXIFEN )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Approved Not Approved Approved Approved Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 371.515 g/mol 0 2 5.9961 False(3/4)
Structure
InChI	InChI=1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25-
InChIKey	NKANXQFJJICGDU-QPLCGJKRSA-N
Links
Gene (197 / 231) ⊖ Less	Source Type Unit Value Gene PMID Assay Other BOSS Text Mining ABCA1 BOSS Text Mining ABCC2 BOSS Text Mining ABCG2 BOSS Text Mining AKR1B1 BOSS Text Mining APP BOSS Text Mining ATP8A2 BOSS Text Mining AURKB BOSS Text Mining BBS9 BOSS Text Mining BCL2 BOSS Text Mining BCL2L1 BOSS Text Mining BMP2 BOSS Text Mining BRCA1 BOSS Text Mining BRD2 BOSS Text Mining C11orf96 BOSS Text Mining C7orf49 BOSS Text Mining CASP3 BOSS Text Mining CASP8 BOSS Text Mining CASP9 BOSS Text Mining CAV3 BOSS Text Mining CBL BOSS Text Mining CBX8 BOSS Text Mining CCND1 BOSS Text Mining CCNE1 BOSS Text Mining CCNL2 BOSS Text Mining CD4 BOSS Text Mining CD44 BOSS Text Mining CDH2 BOSS Text Mining CDK1 BOSS Text Mining CDK2 BOSS Text Mining CDKN2A BOSS Text Mining CDT1 BOSS Text Mining CEACAM3 BOSS Text Mining CEBPZ BOSS Text Mining CLCN3 BOSS Text Mining CSH1 BOSS Text Mining CSPG4 BOSS Text Mining CYCS BOSS Text Mining CYGB BOSS Text Mining CYP2B6 BOSS Text Mining CYP2C8 BOSS Text Mining DAND5 BOSS Text Mining DDR2 BOSS Text Mining DES BOSS Text Mining DNMT1 BOSS Text Mining DNTT BOSS Text Mining DUSP8 BOSS Text Mining EGF BOSS Text Mining EGFR BOSS Text Mining EIF4EBP1 BOSS Text Mining ELF3 BOSS Text Mining EPHB2 BOSS Text Mining ERBB2 BOSS Text Mining ERBB2 BOSS Text Mining ERBB3 BOSS Text Mining EREG BOSS Text Mining ESR1 BOSS Text Mining ESR2 BOSS Text Mining ESRRB BOSS Text Mining ETFB BOSS Text Mining F3 BOSS Text Mining FAM109A BOSS Text Mining FLT3LG BOSS Text Mining FN1 BOSS Text Mining FOXA1 BOSS Text Mining GCK BOSS Text Mining GGH BOSS Text Mining GINS1 BOSS Text Mining GJA1 BOSS Text Mining GPX1 BOSS Text Mining GYPE BOSS Text Mining HDAC2 BOSS Text Mining HLP BOSS Text Mining HMX3 BOSS Text Mining HN1 BOSS Text Mining HOXB13 BOSS Text Mining HPD BOSS Text Mining HRAS BOSS Text Mining HSD11B1 BOSS Text Mining IFNA1 BOSS Text Mining IGF1 BOSS Text Mining IGF1R BOSS Text Mining IGF2 BOSS Text Mining IGFBP1 BOSS Text Mining IGFBP3 BOSS Text Mining IL10 BOSS Text Mining IL17RB BOSS Text Mining IL2 BOSS Text Mining IL3 BOSS Text Mining IL6 BOSS Text Mining INS BOSS Text Mining ISYNA1 BOSS Text Mining JAK2 BOSS Text Mining JUP BOSS Text Mining KCNJ11 BOSS Text Mining KDR BOSS Text Mining KRIT1 BOSS Text Mining KRT5 BOSS Text Mining LCN1 BOSS Text Mining LDB3 BOSS Text Mining LDHA BOSS Text Mining LEP BOSS Text Mining MAP3K1 BOSS Text Mining MAPK3 BOSS Text Mining MCL1 BOSS Text Mining MERTK BOSS Text Mining MMP2 BOSS Text Mining MMP9 BOSS Text Mining MPO BOSS Text Mining MPP6 BOSS Text Mining MSTO1 BOSS Text Mining MTOR BOSS Text Mining MUC16 BOSS Text Mining MYC BOSS Text Mining NCOA3 BOSS Text Mining NEDD9 BOSS Text Mining NFKB1 BOSS Text Mining NGFR BOSS Text Mining NLK BOSS Text Mining NPPB BOSS Text Mining NR4A1 BOSS Text Mining NRG1 BOSS Text Mining NSG1 BOSS Text Mining PAK3 BOSS Text Mining PARP2 BOSS Text Mining PAX3 BOSS Text Mining PCNA BOSS Text Mining PES1 BOSS Text Mining PGP BOSS Text Mining PGR BOSS Text Mining PLXNA3 BOSS Text Mining PNPLA3 BOSS Text Mining POLD4 BOSS Text Mining PPARG BOSS Text Mining PPIG BOSS Text Mining PR@ BOSS Text Mining PRDX2 BOSS Text Mining PRL BOSS Text Mining PRRT2 BOSS Text Mining PSEN2 BOSS Text Mining PTEN BOSS Text Mining PTH BOSS Text Mining PTK2B BOSS Text Mining RAF1 BOSS Text Mining RBP3 BOSS Text Mining RHO BOSS Text Mining RNASEH2A BOSS Text Mining ROS1 BOSS Text Mining RPS6KB1 BOSS Text Mining SART3 BOSS Text Mining SERPINA5 BOSS Text Mining SETD2 BOSS Text Mining SHBG BOSS Text Mining SLC25A20 BOSS Text Mining SLC7A1 BOSS Text Mining SOD1 BOSS Text Mining SOX9 BOSS Text Mining SRSF1 BOSS Text Mining STAT3 BOSS Text Mining TACR2 BOSS Text Mining TAOK1 BOSS Text Mining TAS2R62P BOSS Text Mining TENM1 BOSS Text Mining TFF1 BOSS Text Mining TMX1 BOSS Text Mining TNF BOSS Text Mining TP53 BOSS Text Mining TRA BOSS Text Mining TRAPPC9 BOSS Text Mining TRIP10 BOSS Text Mining TSC1 BOSS Text Mining TYRP1 BOSS Text Mining UBL5 BOSS Text Mining UGT2B15 BOSS Text Mining UGT2B7 BOSS Text Mining VEGFA BOSS Text Mining VIM BOSS Text Mining XCL1 BOSS Text Mining ZNF234 BOSS Text Mining ZNF469 BOSS Text Mining ZNF77 PubChem Potency uM 22.387 ATXN2 - GI(Protien) : PubChem Potency uM 39.811 ATXN2 - GI(Protien) : PubChem Potency uM 35.481 BAZ2B - GI(Protien) : PubChem Potency uM 35.481 CBX1 - GI(Protien) : PubChem Potency-Replicate_1 uM 4.354 CYP19A1 - GI(Protien) : PubChem Potency-Replicate_1 uM 7.696 CYP19A1 - GI(Protien) : PubChem None uM CYP19A1 - GI(Protien) : PubChem Potency uM 10.000 EHMT2 - GI(Protien) : PubChem Potency uM 12.589 EHMT2 - GI(Protien) : PubChem Potency uM 18.888 EHMT2 - GI(Protien) : PubChem Potency-Replicate_1 uM 0.876 ESR1 - GI(Protien) : PubChem Ratio Potency (uM) uM 1.147 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 1.548 ESR1 - GI(Protien) : PubChem Ratio Potency (uM) uM 1.876 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 8.688 ESR1 - GI(Protien) : PubChem ER Potency (uM) uM 9.748 ESR1 - GI(Protien) : PubChem ER Potency (uM) uM 13.170 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 13.685 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 54.941 ESR1 - GI(Protien) : PubChem Ratio Potency (uM) uM 54.954 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 77.429 ESR1 - GI(Protien) : PubChem Potency uM 1.300 GMNN - GI(Protien) : PubChem Potency uM 16.360 IDH1 - GI(Protien) : PubChem None uM KCNQ1 - GI(Protien) : PubChem None uM MLLT3 - GI(Protien) : PubChem Ratio Potency (uM) uM 54.941 PPARD - GI(Protien) : PubChem None uM STK33 - GI(Protien) : PubChem Potency uM 31.623 TP53 - GI(Protien) : PubChem Potency uM 31.623 TP53 - GI(Protien) : PubChem None uM UBE2N - GI(Protien) : ChEMBL Potency nM 35481.300 BAZ2B - Target : CHEMBL1741220 ChEMBL Potency nM 35481.300 CBX1 - Target : CHEMBL1741193 ChEMBL Inhibition - CYP1A2 - Target : CHEMBL3356 ChEMBL Inhibition - CYP2C9 - Target : CHEMBL3397 ChEMBL Inhibition - CYP3A4 - Target : CHEMBL340 ChEMBL Inhibition - CYP3A4 - Target : CHEMBL340 ChEMBL Potency nM 12589.300 EHMT2 - Target : CHEMBL6032 ChEMBL Potency nM 10000.000 EHMT2 - Target : CHEMBL6032 ChEMBL Potency nM 18887.600 EHMT2 - Target : CHEMBL6032 ChEMBL Activity - ESR1 - Target : CHEMBL206 ChEMBL Activity - ESR1 - Target : CHEMBL206 ChEMBL Activity - ESR1 - Target : CHEMBL206 ChEMBL Activity - ESR1 - Target : CHEMBL206 ChEMBL Activity - ESR2 - Target : CHEMBL242 ChEMBL Activity - ESR2 - Target : CHEMBL242 ChEMBL Potency nM 44668.400 KDM4A - Target : CHEMBL5896 ChEMBL Activity - PLD1 - Target : CHEMBL2536 ChEMBL Activity - PLD2 - Target : CHEMBL2734 ChEMBL Activity - PLD2 - Target : CHEMBL2734 ChEMBL Potency nM 31622.800 TP53 - Target : CHEMBL4096 ChEMBL Potency nM 31622.800 TP53 - Target : CHEMBL4096
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