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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : Boss - iproveratril hydrochloride

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Collection	D4 : Boss
Chemical Name	iproveratril hydrochloride ( From PubChem : VERAPAMIL HYDROCHLORIDE )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Approved Not Approved Approved Approved Approved Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 491.063 g/mol 1 6 5.89508 False(3/4)
Structure
InChI	InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H
InChIKey	DOQPXTMNIUCOSY-UHFFFAOYSA-N
Links
Gene (64 / 70) ⊖ Less	Source Type Unit Value Gene PMID Assay Other BOSS Text Mining ABCA1 BOSS Text Mining ABCC2 BOSS Text Mining ABCC3 BOSS Text Mining ABCG2 BOSS Text Mining ACE BOSS Text Mining ACOX2 BOSS Text Mining ACSM3 BOSS Text Mining ADCY8 BOSS Text Mining AGT BOSS Text Mining ATP1B1 BOSS Text Mining ATP8A2 BOSS Text Mining AURKB BOSS Text Mining BANF1P1 BOSS Text Mining BBS9 BOSS Text Mining BCL2 BOSS Text Mining CACNA1S BOSS Text Mining CASP3 BOSS Text Mining CASQ2 BOSS Text Mining CDT1 BOSS Text Mining CYGB BOSS Text Mining CYP2B6 BOSS Text Mining CYP2C8 BOSS Text Mining DDR2 BOSS Text Mining DECR1 BOSS Text Mining F9 BOSS Text Mining GCG BOSS Text Mining GPX1 BOSS Text Mining HK1 BOSS Text Mining HLP BOSS Text Mining IL6 BOSS Text Mining INS BOSS Text Mining KNG1 BOSS Text Mining KRIT1 BOSS Text Mining LDHA BOSS Text Mining MAPK3 BOSS Text Mining NFKBIL1 BOSS Text Mining PLCB4 BOSS Text Mining PLXNA3 BOSS Text Mining PPIG BOSS Text Mining PR@ BOSS Text Mining PRDX2 BOSS Text Mining PRRT2 BOSS Text Mining RHO BOSS Text Mining ROS1 BOSS Text Mining RYR1 BOSS Text Mining SCD BOSS Text Mining SLC22A1 BOSS Text Mining SLC22A2 BOSS Text Mining SLC22A3 BOSS Text Mining SLC25A20 BOSS Text Mining SPARC BOSS Text Mining TNF BOSS Text Mining TP53 BOSS Text Mining TRAPPC9 BOSS Text Mining TYRP1 BOSS Text Mining WLS PubChem None uM ABCB1 - GI(Protien) : PubChem Potency uM 0.631 CYP3A4 - GI(Protien) : PubChem Potency uM 2.512 CYP3A4 - GI(Protien) : PubChem None uM DRD2 - GI(Protien) : PubChem None uM DRD3 - GI(Protien) : PubChem Potency uM 1.413 KCNH2 GI(Protien) : PubChem Potency uM 1.413 KCNH2 GI(Protien) : PubChem Potency uM 3.981 KCNH2 GI(Protien) : PubChem Potency uM 3.981 KCNH2 GI(Protien) : PubChem Potency-Replicate_1 uM 2.512 NR1I2 - GI(Protien) : PubChem Potency uM 16.360 TDP1 - GI(Protien) : ChEMBL Potency nM 2511.900 CYP3A4 - Target : CHEMBL340 ChEMBL Potency nM 631.000 CYP3A4 - Target : CHEMBL340 ChEMBL Potency nM 1584.900 RECQL - Target : CHEMBL1293236
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